Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase.

Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.

1980 • 438 citations

Enzyme-Activated Irreversible Inhibitors

1979 • 420 citations

Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction.

1982 • 398 citations

Chemical Mutagenesis

1982 • 366 citations

Regulatory Mechanisms in the Control of Protein Kinase

1982 • 357 citations

Mutagenesis of the replication point by nitrosoguanidine: Map and pattern of replication of the Escherichia coli chromosome

1968 • 297 citations

Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA

1979 • 260 citations

Transposon-mediated site-specific recombination: A defined in vitro system

1981 • 227 citations

Chromosome Damage and Repair

1981 • 219 citations

Mismatch correction at O6-methylguanine residues in E. coli DNA

1982 • 215 citations

Properties of 3-methyladenine-DNA glycosylase from Escherichia coli

1978 • 190 citations

Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro

1982 • 161 citations

Isolation and characterization of Escherichia coli K-12 mutants unable to induce the adaptive response to simple alkylating agents

1979 • 160 citations

Quantitation of the adaptive response to alkylating agents

1979 • 145 citations

Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichiacoli

1980 • 141 citations

Isolation of mutants of Escherichia coli with increased resistance to alkylating agents: Mutants deficient in thiols and mutants constitutive for the adaptive response

1980 • 95 citations

Repair of O6-ethylguanine in DNA by a chromatin fraction from rat liver: transfer of the ethyl group to an acceptor protein.

1981 • 89 citations

A covalent adduct between the uracil ring and the active site of an aminoacyl tRNA synthetase

1982 • 82 citations

A common mechanism for repair of O6-methylguanine and O6-ethylguanine in DNA

1982 • 76 citations

The uvrD gene of E. coli encodes a DNA-dependent ATPase

1982 • 72 citations

The Inducible Repair of Alkylated DNA

1981 • 70 citations

Time course of O6-methylguanine removal from DNA of N-methyl-N-nitrosourea-treatedhuman fibroblasts

1981 • 69 citations

Abilities of extracts of human lymphocytes to remove O6-methylguanine from DNA

1982 • 62 citations

Efficiency of the adaptive response of Escherichia coli to alkylating agents

1980 • 61 citations

Stimulation of transfer of methyl groups from O⁶-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins

1981 • 54 citations

[3] Mechanism-based irreversible enzyme inhibitors

1977 • 51 citations

A comparison of the mutagenic action of the methyl and ethyl derivatives of nitrosamides and nitrosamidines on Escherichia coli

1974 • 49 citations

Genetic mapping of ada and adc mutations affecting the adaptive response of Escherichia coli to alkylating agents

1982 • 44 citations

Role of the uvrE gene product and of inducible O-methylguanine removal in the induction of mutations by N-methyl-N′-nitro-N-nitrosoguanidine in Escherichia coli

1980 • 34 citations

Limited capacity for the removal of O6-methylguanine and its regeneration in a human lymphoma line

1981 • 32 citations

Changes in O6-methylguanine disappearance from rat liver dna during chronic dimethylnitrosamine administration

1980 • 30 citations

Extracts of chronic lymphocytic leukemia lymphocytes have a high level of DNA repair activity fo O6-methylguanine.

1982 • 29 citations

DNA precursors in chemical mutagenesis: a novel application of DNA sequencing

1982 • 26 citations

Enchancement of nitrosoguanidine mutagenesis by chloramphenicol in Escherichia coli K-12

1978 • 20 citations

Excision of O⁶-methylguanine from DNA by human fibroblasts determined by a sensitive competition method

1982 • 13 citations

Intermediates of chromosomal DNA replication in Escherichia coli

1982 • 6 citations