Sensitivity of human cell strains having different abilities to repair O6-methylguanine in DNA to inactivation by alkylating agents including chloroethylnitrosoureas.

In Vitro Cultivation of Human Tumors: Establishment of Cell Lines Derived From a Series of Solid Tumors2

1973 • 2,213 citations

One Hundred and Twenty-Seven Cultured Human Tumor Cell Lines Producing Tumors in Nude Mice23

1977 • 1,556 citations

Quantitative Correlation of Relative Rates. Comparison of Hydroxide Ion with Other Nucleophilic Reagents toward Alkyl Halides, Esters, Epoxides and Acyl Halides¹

1953 • 606 citations

Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N′-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation

1970 • 500 citations

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

1980 • 371 citations

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

1980 • 315 citations

Biochemical studies on adenovirus multiplication

1963 • 314 citations

A comprehensive quantitative analysis of methylated and ethylated DNA using high pressure liquid chromatography

1980 • 301 citations

Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl)-1-nitrosoureas.

1977 • 297 citations

Some chemical aspects of dose-response relationships in alkylation mutagenesis

1974 • 284 citations

N-nitroso alkylating agents: formation and persistence of alkyl derivatives in mammalian nucleic acids as contributing factors in carcinogenesis.

1979 • 276 citations

Biochemical studies on adenovirus multiplication

1971 • 236 citations

Formation of the cross-link 1-[N3-deoxycytidyl),2-[N1-deoxyguanosinyl]ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea.

1982 • 227 citations

The Modes of Decomposition of 1,3-Bis(2-chloroethyl)-1-nitrosourea and Related Compounds

1967 • 177 citations

Reaction kinetics and biological action in barley of mono-functional methanesulfonic esters

1970 • 171 citations

Human tumor cell strains defective in the repair of alkylation damage

1980 • 169 citations

DNA-protein cross-linking and DNA interstrand cross-linking by haloethylnitrosoureas in L1210 cells.

1978 • 169 citations

DNA crosslinking and cytotoxicity in normal and transformed human cells treated with antitumor nitrosoureas.

1980 • 151 citations

Repair of O⁶-methylguanine in DNA by demethylation is lacking in Mer⁻ human tumor cell strains

1983 • 140 citations

Dependence of mammalian DNA replication on DNA supercoiling II. Effects of novobiocin on DNA synthesis in Chinese hamster ovary cells

1979 • 114 citations

Inhibition of DNA repair by the 1,3-bis(2-chloroethyl)-1-nitrosourea breakdown product, 2-chloroethyl isocyanate.

1974 • 94 citations

Reaction rates and biological action of N-methyl- and N-ethyl-N-Nitrosourea

1970 • 86 citations

CELLULAR REACTIVATION OF ULTRAVIOLET‐IRRADIATED HUMAN ADENOVIRUS 2 IN NORMAL AND XERODERMA PIGMENTOSUM FIBROBLASTS

1974 • 74 citations

Human brain tumour cell strains with deficient host-cell reactivation of N-methyl-N′-nitro-N-nitrosoguanidine-damaged adenovirus 5

1979 • 74 citations

FANCONI'S ANEMIA A CONDITION POSSIBLY ASSOCIATED WITH A DEFECTIVE DNA REPAIR

1978 • 70 citations

Modifications of DNA by different haloethylnitrosoureas.

1982 • 69 citations

Decreased DNA repair synthesis and defective colony-forming ability of ataxia telangiectasia fibroblast cell strains treated with N-methyl-N'-nitro-N-nitrosoguanidine.

1980 • 69 citations

Hypersensitivity to N-methyl-N'-nitro-N-nitrosoguanidine in fibroblasts from patients with Huntington disease, familial dysautonomia, and other primary neuronal degenerations.

1981 • 68 citations

Relationship of DNA repair phenotypes of human fibroblast and tumor strains to killing by N-methyl-N'-nitro-N-nitrosoguanidine.

1984 • 63 citations

Genetic effects of N-methyl-N′-nitro-N-nitrosoguanidine and its homologs

1982 • 58 citations

Differential response by human melanoma cells to 1,3-bis-(2-chloroethyl)-1-nitrosourea and bleomycin

1973 • 55 citations

Mechanism of action of the nitrosoureas—V

1983 • 49 citations

Excision repair by human fibroblasts of DNA damaged by r-7, t-8-dihydroxy-t-9,10-OXY-7,8,9,10-tetrahydrobenzo(a)pyrene

1978 • 44 citations

Differential inhibition of the rejoining of X-ray-induced DNA strand breaks in normal and transformed human fibroblasts treated with 1,3-bis(2-chloroethyl)-1-nitrosourea in vitro.

1978 • 25 citations

Reaction kinetics of N-methyl-N'-nitro-N-nitrosoguanidine and N-ethyl-N'-nitro-N-nitrosoguanidine

1974 • 23 citations

Inhibition of excision-repair of ultraviolet damage in human cells by exposure to methyl methanesulfonate

1981 • 22 citations

MNNG-pretreatment of a human kidney carcinoma cell strain decreases its ability to repair MNNG-treated adenovirus 5

1981 • 11 citations

Human tumor strains defective in the repair of alkylated DNA fail to regenerate rapidly-sedimenting nucleoids after N-methyl-N′ -nitro-N-nitrosoguanidine treatment

1981 • 6 citations