Retrovirus-mediated gene transfer in cancer therapy

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

The biology of interleukin-6

1989 • 1,964 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

The Basic Science of Gene Therapy

1993 • 1,767 citations

Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

1981 • 1,611 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

1992 • 1,530 citations

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

1990 • 1,465 citations

The biology of interleukin-6

1989 • 1,459 citations

Gene Transfer into Humans — Immunotherapy of Patients with Advanced Melanoma, Using Tumor-Infiltrating Lymphocytes Modified by Retroviral Gene Transduction

1990 • 1,307 citations

Redesign of Retrovirus Packaging Cell Lines To Avoid Recombination Leading to Helper Virus Production

1986 • 1,276 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells

1989 • 1,097 citations

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

1986 • 962 citations

Human gene therapy comes of age

1992 • 927 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells

1988 • 832 citations

Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production.

1986 • 828 citations

Site-specific integration by adeno-associated virus.

1996 • 803 citations

Murine interleukin-4 displays potent anti-tumor activity in vivo

1989 • 790 citations

Targeted integration of adeno-associated virus (AAV) into human chromosome 19.

1991 • 774 citations

Treatment of Established Renal Cancer by Tumor Cells Engineered to Secrete Interleukin-4

1991 • 733 citations

Receptor-mediated gene delivery and expression in vivo.

1988 • 642 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 637 citations

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.

1990 • 628 citations

A detailed model of reverse transcription and tests of crucial aspects

1979 • 621 citations

Suppression of Tumorigenicity of Human Prostate Carcinoma Cells by Replacing a Mutated RB Gene

1990 • 606 citations

Human gene therapy

1992 • 559 citations

Transport of cationic amino acids by the mouse ecotropic retrovirus receptor

1991 • 552 citations

Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer.

1992 • 544 citations

Genetic Mechanisms of Tumor Suppression by the Human p53 Gene

1990 • 540 citations

Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells.

1986 • 533 citations

Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes.

1987 • 533 citations

Curability of Tumors Bearing Herpes Thymidine Kinase Genes Transfered by Retroviral Vectors

1990 • 514 citations

Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system.

1992 • 511 citations

Selection of Drug-Resistant Bone Marrow Cells in Vivo After Retroviral Transfer of Human MDR 1

1992 • 500 citations

Progress Toward Human Gene Therapy

1989 • 484 citations

Lymphokines

1987 • 459 citations

In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.

1993 • 442 citations

Cell-surface receptor for ecotropic murine retroviruses is a basic amino-acid transporter

1991 • 439 citations

Gene Therapy for the Treatment of Brain Tumors Using Intra-Tumoral Transduction with the Thymidine Kinase Gene and Intravenous Ganciclovir. National Institutes of Health

1993 • 420 citations

Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity.

1990 • 414 citations

High-efficiency gene transfer into mammalian cells: generation of helper-free recombinant retrovirus with broad mammalian host range.

1984 • 407 citations

B cell precursor growth-promoting activity. Purification and characterization of a growth factor active on lymphocyte precursors.

1988 • 379 citations

The Encephalomyocarditis Virus Internal Ribosome Entry Site Allows Efficient Coexpression of Two Genes from a Recombinant Provirus in Cultured Cells and in Embryos

1991 • 333 citations

Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy.

1991 • 315 citations

Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo.

1991 • 315 citations

Antitumor activity of murine tumor necrosis factor (TNF) against transplanted murine tumors and heterotransplanted human tumors in nude mice

1984 • 313 citations

Exogenous expression of mouse interferon gamma cDNA in mouse neuroblastoma C1300 cells results in reduced tumorigenicity by augmented anti-tumor immunity.

1989 • 284 citations

Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors.

1991 • 283 citations

Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer.

1991 • 279 citations

The antitumor function of tumor necrosis factor (TNF), I. Therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited by severe toxicity.

1988 • 276 citations

Mechanisms of p53 loss in human sarcomas.

1990 • 273 citations

Immunotherapy of cancer using interleukin 2: current status and future prospects

1988 • 256 citations

Receptor choice determinants in the envelope glycoproteins of amphotropic, xenotropic, and polytropic murine leukemia viruses

1992 • 242 citations

The encephalomyocarditis virus internal ribosome entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and in embryos.

1991 • 235 citations

Retroviral vectors containing putative internal ribosome entry sites: development of a polycistronic gene transfer system and applications to human gene therapy

1992 • 211 citations

Regression of bladder tumors in mice treated with interleukin 2 gene-modified tumor cells.

1993 • 210 citations

Retroviral vectors displaying functional antibody fragments

1993 • 207 citations

Organization of the Murine Mx Gene and Characterization of Its Interferon- and Virus-Inducible Promoter

1988 • 206 citations

New Approaches to the Immunotherapy of Cancer Using Interleukin-2

1988 • 202 citations

Enhancement of experimental metastasis by tumor necrosis factor.

1993 • 198 citations

Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector.

1989 • 192 citations

Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA

1991 • 188 citations

Role of neutrophils and CD4+ T lymphocytes in the primary and memory response to nonimmunogenic murine mammary adenocarcinoma made immunogenic by IL-2 gene.

1992 • 185 citations

Factors involved in production of helper virus-free retrovirus vectors

1986 • 181 citations

Inhibition of colon and breast carcinoma cell growth by interleukin-4.

1992 • 169 citations

Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct.

1993 • 162 citations

Cells secreting tumour necrosis factor show enhanced metastasis in nude mice

1990 • 154 citations

Treatment of glioma by engineered interleukin 4-secreting cells.

1993 • 149 citations

Antimetastatic vaccination of tumor-bearing mice with two types of IFN-gamma gene-inserted tumor cells.

1993 • 142 citations

Expression of murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicity in vivo.

1992 • 140 citations

The prokaryotic neomycin-resistance-encoding gene acts as a transcriptional silencer in eukaryotic cells

1991 • 139 citations

Targeting of Retroviral Vectors for Gene Therapy

1993 • 137 citations

A versatile and potentially general approach to the targeting of specific cell types by retroviruses: application to the infection of human cells by means of major histocompatibility complex class I and class II antigens by mouse ecotropic murine leukemia virus-derived viruses.

1989 • 131 citations

Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter.

1988 • 124 citations

Interleukin 4/B cell stimulatory factor 1: one lymphokine, many functions ¹

1987 • 124 citations

Function of Two Discrete Regions Is Required for Nuclear Localization of Polymerase Basic Protein 1 of A/WSN/33 Influenza Virus (H1 N1)

1990 • 123 citations

IL-7 promotes thymocyte proliferation and maintains immunocompetent thymocytes bearing alpha beta or gamma delta T-cell receptors in vitro: synergism with IL-2.

1989 • 119 citations

Immunotherapy of Malignancy by In Vivo Gene Transfer into Tumors

1992 • 117 citations

High efficiency gene transfer into primary human tumor explants without cell selection.

1993 • 116 citations

Retroviral Vector-Mediated Transduction of K-rasAntisense RNA into Human Lung Cancer Cells Inhibits Expression of the Malignant Phenotype

1993 • 115 citations

Basis for receptor specificity of nonecotropic murine leukemia virus surface glycoprotein gp70SU

1992 • 112 citations

Vaccinations with tumor cells genetically engineered to produce different cytokines: effectivity not superior to a classical adjuvant.

1993 • 110 citations

Genetic modification of a murine fibrosarcoma to produce interleukin 7 stimulates host cell infiltration and tumor immunity.

1992 • 105 citations

Efficient Incorporation of Human CD4 Protein into Avian Leukosis Virus Particles

1990 • 105 citations

Transfer and expression of cloned genes using retrovial vectors

1986 • 103 citations

Development of retrovirus vectors useful for expressing genes in cultured murine embryonal cells and hematopoietic cells in vivo

1988 • 102 citations

Growth inhibition of glioma cells transfected with the human beta-interferon gene by liposomes coupled with a monoclonal antibody.

1990 • 101 citations

Retroviral vectors for introduction of genes into mammalian cells.

1988 • 100 citations

Long-term inhibition of tumor growth by tumor necrosis factor in the absence of cachexia or T-cell immunity.

1991 • 99 citations

Anti‐metastatic vaccination of tumor‐bearing mice with il‐2‐gene‐inserted tumor cells

1993 • 99 citations

Comparison of promoter suppression in avian and murine retrovirus vectors

1986 • 95 citations

Transfer of genes into embryonal carcinoma cells by retrovirus infection: efficient expression from an internal promoter.

1985 • 94 citations

Decreased tumorigenicity of a transplantable rat sarcoma following transfer and expression of an IL‐2 cDNA

1991 • 92 citations

Fibrosarcoma cells transduced with the IL-6 gene exhibited reduced tumorigenicity, increased immunogenicity, and decreased metastatic potential.

1992 • 90 citations

Granulocyte colony-stimulating factor (G-CSF) gene transduction in murine adenocarcinoma drives neutrophil-mediated tumor inhibition in vivo. Neutrophils discriminate between G-CSF-producing and G-CSF-nonproducing tumor cells.

1992 • 88 citations

The efficiency of cell targeting by recombinant retroviruses depends on the nature of the receptor and the composition of the artificial cell-virus linker

1992 • 87 citations

Expression of the GM-CSF gene after retroviral transfer in hematopoietic stem cell lines induces synchronous granulocyte-macrophage differentiation

1991 • 87 citations

Chemical modification of an ecotropic murine leukemia virus results in redirection of its target cell specificity

1991 • 86 citations

Retroviral vector-mediated lymphokine gene transfer into human renal cancer cells.

1992 • 83 citations

Cytokine secretion by genetically modified nonimmunogenic murine fibrosarcoma. Tumor inhibition by IL-2 but not tumor necrosis factor.

1993 • 83 citations

Tumor Suppressor Genes: New Prospects for Cancer Research

1991 • 81 citations

Retroviral gene transfer induced constitutive expression of interleukin- 2 or interferon-gamma in irradiated human melanoma cells

1992 • 81 citations

Local administration of cells containing an inserted IL-2 gene and producing IL-2 inhibits growth of human tumours in nu/nu mice

1988 • 79 citations

Reduced tumorigenicity of fibrosarcomas which constitutively generate il‐1α either spontaneously or following il‐1α gene transfer

1992 • 75 citations

In vivo and in vitro characteristics of interleukin 6-transfected B16 melanoma cells.

1992 • 71 citations

Site-specific integration by adeno-associated virus.

1990 • 71 citations

Gene targeting with retroviral vectors: recombination by gene conversion into regions of nonhomology.

1989 • 71 citations

Combining Chemotherapy With Biological Response Modifiers in Treatment of Cancer

1988 • 71 citations

Expression of tumor necrosis factor by different tumor cell lines results either in tumor suppression or augmented metastasis.

1993 • 66 citations

Replication-defective chimeric helper proviruses and factors affecting generation of competent virus: expression of Moloney murine leukemia virus structural genes via the metallothionein promoter.

1987 • 60 citations

Tumor necrosis factor: still a promising agent.

1989 • 58 citations

A Pilot Study of Immunization with HLA-A2 Matched Allogeneic Melanoma Cells That Secrete Interleukin-2 in Patients with Metastatic Melanoma

1992 • 57 citations

Retrovirally transduced antisense sequences stably suppress P210BCR-ABL expression and inhibit the proliferation of BCR/ABL-containing cell lines

1993 • 56 citations

Lack of tumorigenicity of interleukin 4 autocrine growing cells seems related to the anti-tumor function of interleukin 4

1990 • 54 citations

Inactivation of a transfected gene in human fibroblasts can occur by deletion, amplification, phenotypic switching, or methylation.

1987 • 53 citations

Immunization of Cancer Patients Using Autologous Cancer Cells Modified by Insertion of the Gene for Tumor Necrosis Factor (National Institutes of Health)

1992 • 50 citations

Interferons in cell growth and development

1989 • 44 citations

Immunization of Cancer Patients Using Autologous Cancer Cells Modified by Insertion of the Gene for Interleukin-2 (National Institutes of Health)

1992 • 43 citations

Characterization of recombinant helper retroviruses from moloney-based vectors in ecotropic and amphotropic packaging cell lines

1991 • 43 citations

New Drugs: Antisense Agents in Cancer Research and Therapeutics

1991 • 43 citations

Antibody-mediated binding of a murine ecotropic moloney retroviral vector to human cells allows internalization but not the establishment of the proviral state

1988 • 43 citations

Efficient gene expression in mammalian cells from a dicistronic transcriptional unit in an improved retroviral vector

1991 • 43 citations

Expression of the tumor necrosis factor gene in tumor cells correlates with reduced tumorigenicity and reduced invasiveness in vivo.

1991 • 42 citations

Immunotherapy with cytokine gene-transduced tumor cells

1992 • 39 citations

A spleen necrosis virus-based retroviral vector which expresses two genes from a dicistronic mRNA

1992 • 38 citations

A Pilot Study of Immunization with Interleukin-2 Secreting Allogeneic HLA-A2 Matched Renal Cell Carcinoma Cells in Patients with Advanced Renal Cell Carcinoma

1992 • 33 citations

Mouse mammary tumor virus mediated transfer and expression of neomycin resistance to infected cultured cells

1986 • 32 citations

Phase I Study of Cytokine-Gene Modified Autologous Neuroblastoma Cells for Treatment of Relapse/Refractory Neuroblastoma

1992 • 31 citations

Autologous Bone Marrow Transplant for Children with AML in First Complete Remission: Use of Marker Genes to Investigate the Biology of Marrow Reconstitution and the Mechanism of Relapse

1991 • 31 citations

Tumour targeting with antibody-coupled liposomes: Failure to achieve accumulation in xenografts and spontaneous liver metastases

1990 • 30 citations

Hormonal regulation of chimeric genes containing the phosphoenolpyruvate carboxykinase promoter regulatory region in hepatoma cells infected by murine retroviruses.

1988 • 30 citations

Interleukin‐1 produced by tumorigenic fibroblasts influences tumor rejection

1992 • 29 citations

Autologous Bone Marrow Transplantation for CML in Which Retroviral Markers Are Used to Discriminate Between Relapse Which Arises from Systemic Disease Remaining after Preparative Therapy Versus Relapse due to Residual Leukemia Cells in Autologous Marrow: A Pilot Trial. The University of Texas M.D. Anderson Cancer Center

1991 • 27 citations

Characterization of a bicistronic retroviral vector composed of the swine vesicular disease virus internal ribosome entry site

1993 • 20 citations

Interleukin 7 stimulates growth of fetal thymic precursors of cytolytic cells: induction of effector function by interleukin 2 and inhibition by interleukin 4

1990 • 17 citations

Local immunotherapy of cancer with interleukin 2

1989 • 16 citations

A Phase I Trial of High-Dose Carboplatin and Etoposide with Autologous Marrow Support for Treatment of Stage D Neuroblastoma in First Remission: Use of Marker Genes to Investigate the Biology of Marrow Reconstitution and the Mechanism of Relapse

1991 • 16 citations

The SV40 enhancer: Transcriptional regulation through a hierarchy of combinatorial interactions

1993 • 16 citations

Development of a retroviral vector for inducible expression of transforming growth factor beta 1

1990 • 14 citations

Characterization of human recombinant tumor necrosis factor-alpha antiproliferative effects on human cells in culture.

1988 • 13 citations

Retrovirus mediated transfer and expression of GM-CSF in haematopoietic cells

1990 • 10 citations

Retrovirus-mediated gene transfer of tumor necrosis factor alpha into colon carcinoma cells generates a growth inhibition.

1993 • 10 citations

Research and potential clinical applications of retroviral vectors.

1987 • 7 citations

Observations with tumour necrosis factor gene-transfected tumours.

1994 • 6 citations

Tumour immunotherapy

1989 • 6 citations