Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.

Biology of Natural Killer Cells

1989 • 2,970 citations

Immunity to Methylcholanthrene-Induced Sarcomas

1957 • 1,241 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

Murine interleukin-4 displays potent anti-tumor activity in vivo

1989 • 790 citations

Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2.

1985 • 737 citations

Antigenic properties of methylcholanthrene-induced tumors in mice of the strain of origin.

1953 • 686 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 637 citations

The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene

1980 • 556 citations

ANTIGENIC PROPERTIES OF CHEMICALLY INDUCED TUMORS*

1962 • 528 citations

A critique of the evidence for active host defence against cancer, based on personal studies of 27 murine tumours of spontaneous origin

1976 • 478 citations

Tumor rejection antigens of chemically induced sarcomas of inbred mice.

1986 • 463 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 416 citations

Effect of internal viral sequences on the utility of retroviral vectors

1987 • 351 citations

Cancer Immunotherapy Using Interleukin-2 and Interleukin-2-Activated Lymphocytes

1986 • 307 citations

Exogenous expression of mouse interferon gamma cDNA in mouse neuroblastoma C1300 cells results in reduced tumorigenicity by augmented anti-tumor immunity.

1989 • 284 citations

Augmentation of the anti-tumor therapeutic efficacy of long-term cultured T lymphocytes by in vivo administration of purified interleukin 2.

1982 • 267 citations

Cell surface antigens of chemically induced sarcomas of the mouse. I. Murine leukemia virus-related antigens and alloantigens on cultured fibroblasts and sarcoma cells: description of a unique antigen on BALB/c Meth A sarcoma.

1977 • 231 citations

Production and characterization of monoclonal antibodies to human interleukin 2: strategy and tactics.

1983 • 203 citations

Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector.

1989 • 192 citations

Suppressor Cells: Permitters and Promoters of Malignancy?

1979 • 162 citations

Immunosuppression and the Role of Suppressive Factors in Cancer

1977 • 162 citations

Interleukin 2 is both necessary and sufficient for the growth and differentiation of lectin-stimulated cytolytic T lymphocyte precursors.

1985 • 141 citations

The systemic administration of purified interleukin 2 enhances the ability of sensitized murine lymphocytes to cure a disseminated syngeneic lymphoma.

1984 • 137 citations

In Vitro Induction of Cytotoxicity against Syngeneic Mastocytoma and Its Suppression by Spleen and Thymus Cells from Tumor-Bearing Mice

1976 • 118 citations

Eradication of disseminated murine leukemia by treatment with high-dose interleukin 2.

1986 • 105 citations

Lymphocytes generated by in vivo priming and in vitro sensitization demonstrate therapeutic efficacy against a murine tumor that lacks apparent immunogenicity.

1989 • 89 citations

Characterization of Suppressor Cells in Mice Bearing Syngeneic Mastocytoma

1977 • 87 citations

Helper strategy in tumor immunology: Expansion of helper lymphocytes and utilization of helper lymphokines for experimental and clinical immunotherapy

1988 • 69 citations

Adoptive immunotherapy of microscopic and advanced visceral metastases with in vitro sensitized lymphoid cells from mice bearing progressive tumors.

1988 • 64 citations

Functional and antigenic properties of cultured T cells in the cell mediated lympholysis (CML) assay

1982 • 23 citations

Cancer Immunotherapy Using Interleukin-2 and Interleukin-2-Activated Lymphocytes

1986 • 22 citations

Expression of a Cloned Human Interleukin-2 cDNA Is Enhanced by the Substitution of a Heterologous mRNA Leader Region

1988 • 21 citations

Immunogenicity of "nonimmunogenic" tumors.

1984 • 11 citations

Reconstitution of high affinity IL-2 receptor expression in a human T-cell line using a retroviral cDNA expression vector.

1987 • 10 citations

More on the relevance of animal tumor models: immunogenicity of transplantable leukemias of recent origin in syngeneic strain 2 guinea pigs.

1984 • 8 citations