In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

1990 • 1,465 citations

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

1986 • 962 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

Murine interleukin-4 displays potent anti-tumor activity in vivo

1989 • 790 citations

Curability of Tumors Bearing Herpes Thymidine Kinase Genes Transfered by Retroviral Vectors

1990 • 514 citations

Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system.

1992 • 511 citations

Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity.

1990 • 414 citations

Immunological aspects of grafting in the mammalian central nervous system. A review and speculative synthesis

1988 • 296 citations

Targeting of an inducible toxic phenotype in animal cells.

1988 • 252 citations

In Vivo Antitumor Activity of Tumor-Infiltrating Lymphocytes Expanded in Recombinant Interleukin-2

1987 • 250 citations

Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene.

1991 • 216 citations

Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line

1990 • 195 citations

The 9L rat brain tumor: Description and application of an animal model

1981 • 166 citations

Xenogenization of a mouse lung carcinoma (3LL) by transfection with an allogeneic class I major histocompatibility complex gene (H-2Ld).

1987 • 57 citations