Inactivation of a transfected gene in human fibroblasts can occur by deletion, amplification, phenotypic switching, or methylation.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.

1982 • 1,333 citations

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor

1978 • 1,284 citations

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

1981 • 1,048 citations

Gene amplification in cultured animal cells

1984 • 639 citations

5-Methylcytosine, Gene Regulation, and Cancer

1983 • 425 citations

Altering gene expression with 5-azacytidine

1985 • 408 citations

Genes, Chromosomes, and Neoplasia

1981 • 264 citations

Integration and excision of SV40 DNA from the chromosome of a transformed cell

1980 • 169 citations

Gene amplification and gene correction in somatic cells

1982 • 149 citations

In vivo somatic mutations in human lymphocytes frequently result from major gene alterations

1985 • 146 citations

5-Azacytidine-Induced Reactivation of a Herpes Simplex Thymidine Kinase Gene

1982 • 144 citations

Detection of deletion mutations in pSV2gpt-transformed cells.

1984 • 134 citations

Abnormal kinetics of DNA synthesis in ultraviolet light-irradiated cells from patients with Cockayne's syndrome.

1979 • 124 citations

Analyses of mutation in pSV2gpt-transformed CHO cells

1986 • 87 citations

Quantitative and molecular analyses of ethyl methanesulfonate- and ICR 191-induced mutation in AS52 cells

1986 • 72 citations

Modulation of transfected gene expression mediated by changes in chromatin structure

1982 • 72 citations

Expression of transferred thymidine kinase genes is controlled by methylation.

1982 • 71 citations

Phenotypic Switching in Cells Transformed with the Herpes Simplex Virus Thymidine Kinase Gene

1982 • 52 citations

Variable stability of a selectable provirus after retroviral vector gene transfer into human cells.

1986 • 47 citations

Nucleotide sequence of theEsherichia colixanthine-guanine phosphoribosyl transferase gene

1983 • 46 citations

The nature of mutants induced by ionizing radiation in cultured hamster cells

1986 • 44 citations

Coordinate modulation of transfected HSV thymidine kinase and human globin genes

1983 • 41 citations

The use of a cloned bacterial gene to study mutation in mammalian cells

1983 • 41 citations

Phenotypic Switching in Cells Transformed with the Herpes Simplex Virus Thymidine Kinase Gene

1982 • 28 citations

Amplification versus mutation as a mechanism for reversion of anHGPRT mutation

1984 • 25 citations

Variable Stability of a Selectable Provirus after Retroviral Vector Gene Transfer into Human Cells

1986 • 16 citations

Transient assay, by [3H]guanine incorporation of Escherichia coli xanthine-guanine phosphoribosyl transferase (GPT) in transfected human fibroblasts

1985 • 2 citations