Expression of tumor necrosis factor by different tumor cell lines results either in tumor suppression or augmented metastasis.

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

Redesign of Retrovirus Packaging Cell Lines To Avoid Recombination Leading to Helper Virus Production

1986 • 1,276 citations

Human gene therapy comes of age

1992 • 927 citations

Endothelial Cell Gene Expression of a Neutrophil Chemotactic Factor by TNF-α, LPS, and IL-1β

1989 • 785 citations

Tumors secreting human TNF/cachectin induce cachexia in mice

1987 • 634 citations

Tumor necrosis factor.

1992 • 601 citations

Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis.

1990 • 447 citations

Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin.

1990 • 369 citations

Effect of internal viral sequences on the utility of retroviral vectors

1987 • 351 citations

[Tumor necrosis factor].

1990 • 340 citations

Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors.

1991 • 283 citations

Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer.

1991 • 279 citations

The antitumor function of tumor necrosis factor (TNF), I. Therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited by severe toxicity.

1988 • 276 citations

Metabolic effects of cachectin/tumor necrosis factor are modified by site of production. Cachectin/tumor necrosis factor-secreting tumor in skeletal muscle induces chronic cachexia, while implantation in brain induces predominantly acute anorexia.

1990 • 228 citations

Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon gamma.

1993 • 221 citations

Characterization of the antitumor activities of human tumor necrosis factor-alpha and the comparison with other cytokines: induction of tumor-specific immunity.

1987 • 200 citations

Interleukin 1-induced augmentation of experimental metastases from a human melanoma in nude mice.

1990 • 199 citations

Tumor metastases and cell‐mediated immunity in a model system in DBA/2 mice. I. Tumor invasiveness in vitro and metastasis formation in vivo

1979 • 159 citations

Cells secreting tumour necrosis factor show enhanced metastasis in nude mice

1990 • 154 citations

Analysis of cytokine mRNA levels in interleukin‐4‐transgenic mice by quantitative polymerase chain reaction

1992 • 139 citations

Tumor cell-endothelial interactions. Increased adhesion of human melanoma cells to activated vascular endothelium.

1988 • 137 citations

Immunologically mediated regression of a murine lymphoma after treatment with anti-L3T4 antibody. A consequence of removing L3T4+ suppressor T cells from a host generating predominantly Lyt-2+ T cell-mediated immunity.

1988 • 118 citations

The Biology Of Cachectin/TNF: A Primary Mediator Of The Host Response

1989 • 115 citations

Development of retrovirus vectors useful for expressing genes in cultured murine embryonal cells and hematopoietic cells in vivo

1988 • 102 citations

Long-term inhibition of tumor growth by tumor necrosis factor in the absence of cachexia or T-cell immunity.

1991 • 99 citations

Response of Syngeneic Murine Lymphomata to Immunotherapy in Relation to the Antigenicity of the Tumour

1972 • 99 citations

Expression of cytokine genes, including IL-6, in human malignant melanoma cell lines

1992 • 93 citations

Tnf modulation of endothelial and neutrophil adhesion

1992 • 30 citations

Gene therapy researcher under fire over controversial cancer trials

1992 • 11 citations