The War Against the Interferon-induced dsRNA-Activated Protein Kinase: Can Viruses Win?

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

INTERFERONS AND THEIR ACTIONS

1987 • 1,838 citations

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1990 • 1,003 citations

Biochemistry of Interferons and Their Actions

1982 • 868 citations

The interferon system. A bird's eye view of its biochemistry.

1992 • 633 citations

Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities

1991 • 600 citations

Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex.

1982 • 580 citations

Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation

1988 • 401 citations

Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection

1982 • 395 citations

Adenovirus virus-associated RNA and translation control

1991 • 387 citations

Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2α kinase

1986 • 358 citations

Interferon-Induced Proteins and the Antiviral State

1990 • 353 citations

Poliovirus proteinase 2A induces cleavage of eucaryotic initiation factor 4F polypeptide p220

1987 • 329 citations

Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2.

1992 • 325 citations

Autophosphorylation of the protein kinase dependent on double-stranded RNA.

1987 • 301 citations

The Regulation of Initiation of Mammalian Protein Synthesis

1981 • 266 citations

A mechanism for the control of protein synthesis by adenovirus VA RNAI

1986 • 256 citations

Vaccinia virus-encoded elF-2α homolog abrogates the antiviral effect of interferon

1991 • 233 citations

2-Aminopurine Selectively Inhibits the Induction of β-Interferon, c- fos , and c- myc Gene Expression

1988 • 233 citations

Recombinant Epstein-Barr virus with small RNA (EBER) genes deleted transforms lymphocytes and replicates in vitro.

1991 • 220 citations

Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system.

1991 • 207 citations

Inhibitory activity for the interferon-induced protein kinase is associated with the reovirus serotype 1 sigma 3 protein.

1988 • 204 citations

Purification of the eukaryotic initiation factor 2-eukaryotic initiation factor 2B complex and characterization of its guanine nucleotide exchange activity during protein synthesis initiation.

1983 • 203 citations

The Double Stranded RNA-Activated Protein Kinase Induced by Interferon: dsRNA-PK

1989 • 202 citations

Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: A novel translational control mechanism

1989 • 196 citations

The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation

1989 • 184 citations

Adenovirus VAI RNA complexes with the 68 000 Mr protein kinase to regulate its autophosphorylation and activity.

1987 • 181 citations

A GDP/GTP exchange factor essential for eukaryotic initiation factor 2 cycling in Ehrlich ascites tumor cells and its regulation by eukaryotic initiation factor 2 phosphorylation.

1983 • 177 citations

2B or not 2B: Regulation of the catalytic utilization of elF-2

1983 • 172 citations

Interferon-Induced and Double-Stranded RNA-Activated Enzymes: A Specific Protein Kinase and 2′,5′-Oligoadenylate Synthetases

1991 • 170 citations

Mutational analysis of the 5′ non-coding region of human immunodeficiency virus type 1: effects of secondary structure on translation.

1988 • 168 citations

Purification and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from influenza virus-infected cells.

1990 • 164 citations

Binding of Epstein-Barr virus small RNA EBER-1 to the double-stranded RNA-activated protein kinase DAI

1991 • 162 citations

Inhibition of influenza viral mRNA synthesis in cells expressing the interferon-induced Mx gene product

1985 • 159 citations

Regulation of a protein synthesis initiation factor by adenovirus virus-associated RNAI

1985 • 157 citations

Adenovirus VAI RNA prevents phosphorylation of the eukaryotic initiation factor 2 alpha subunit subsequent to infection.

1985 • 155 citations

Control of the Interferon-Induced 68-Kilodalton Protein Kinase by the HIV-1 tat Gene Product

1990 • 155 citations

Inhibition of interferon-inducible gene expression by adenovirus E1A proteins: block in transcriptional complex formation.

1991 • 145 citations

The binding of double-stranded RNA and adenovirus VAI RNA to the interferon-induced protein kinase

1989 • 143 citations

Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cells.

1985 • 138 citations

Activation of interferon-regulated, dsRNA-dependent enzymes by human immunodeficiency virus-1 leader RNA

1989 • 135 citations

Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded-RNA-activated protein kinase.

1990 • 131 citations

Gene induction by interferons and double-stranded RNA: selective inhibition by 2-aminopurine.

1988 • 126 citations

Characterization of a vaccinia virus-encoded double-stranded RNA-binding protein that may be involved in inhibition of the double-stranded rna-dependent protein kinase

1991 • 125 citations

Transcription of interferon-stimulated genes is induced by adenovirus particles but is suppressed by E1A gene products

1988 • 124 citations

Identification of the double-stranded RNA-binding domain of the human interferon-inducible protein kinase.

1992 • 121 citations

Translational control by adenovirus: lack of virus-associated RNAI during adenovirus infection results in phosphorylation of initiation factor eIF-2 and inhibition of protein synthesis.

1985 • 117 citations

Characterization of the double-stranded RNA implicated in the inhibition of protein synthesis in cells infected with a mutant adenovirus defective for VA RNA

1988 • 116 citations

Characterization of a specific kinase inhibitory factor produced by vaccinia virus which inhibits the interferon-induced protein kinase

1984 • 114 citations

Two small RNAs encoded by Epstein-Barr virus can functionally substitute for the virus-associated RNAs in the lytic growth of adenovirus 5.

1983 • 113 citations

The integrity of the stem structure of human immunodeficiency virus type 1 Tat-responsive sequence of RNA is required for interaction with the interferon-induced 68,000-Mr protein kinase

1991 • 111 citations

Influenza virus regulates protein synthesis during infection by repressing autophosphorylation and activity of the cellular 68,000-Mr protein kinase

1988 • 108 citations

Interferon-mediated, double-stranded RNA-dependent protein kinase is inhibited in extracts from vaccinia virus-infected cells

1984 • 101 citations

The eukaryotic initiation factor 2-associated 67-kDa polypeptide (p67) plays a critical role in regulation of protein synthesis initiation in animal cells.

1992 • 94 citations

Interaction of adenovirus VA RNAI with the protein kinase DAI: Nonequivalence of binding and function

1990 • 93 citations

Mechanism of interferon action activation of the human P1/eIF-2α protein kinase by individual reovirus s-class mRNAs: s1 mRNA is a potent activator relative to s4 mRNA

1989 • 92 citations

Translational control by influenza virus: suppression of the kinase that phosphorylates the alpha subunit of initiation factor eIF-2 and selective translation of influenza viral mRNAs.

1986 • 92 citations

Growth-related expression of a double-stranded RNA-dependent protein kinase in 3T3 cells.

1984 • 91 citations

Poliovirus-induced inhibition of host-cell protein synthesis

1982 • 84 citations

Translational control by the Epstein‐Barr virus small RNA EBER‐1

1990 • 84 citations

Modulation of Nuclear Matrix-associated 2′,5′-Oligoadenylate Metabolism and Ribonuclease L Activity in H9 Cells by Human Immunodeficiency Virus

1989 • 82 citations

Inhibition of translation in cells infected with a poliovirus 2Apro mutant correlates with phosphorylation of the alpha subunit of eucaryotic initiation factor 2

1989 • 80 citations

Construction and analysis of additional adenovirus substitution mutants confirm the complementation of VAI RNA function by two small RNAs encoded by Epstein-Barr virus

1985 • 79 citations

Mechanism of interferon action. Purification and substrate specificities of the double-stranded RNA-dependent protein kinase from untreated and interferon-treated mouse fibroblasts.

1985 • 78 citations

Effects of mutations in stem and loop regions on the structure and function of adenovirus VA RNAI.

1988 • 78 citations

The Antiviral Potentials of Mx Proteins

1991 • 75 citations

Detection of activated double-stranded RNA-dependent protein kinase in 3T3-F442A cells.

1988 • 74 citations

Binding of Tat Protein to TAR Region of Human Immunodeficiency Virus Type 1 Blocks TAR-Mediated Activation of (2′-5′)Oligoadenylate Synthetase

1990 • 69 citations

Vaccinia specific kinase inhibitory factor prevents translational inhibition by double-stranded RNA in rabbit reticulocyte lysate

1989 • 63 citations

Binding of the adenovirus VAI RNA to the interferon-induced 68-kDa protein kinase correlates with function.

1991 • 61 citations

Functional expression and characterization of the interferon-induced double-stranded RNA activated P68 protein kinase from Escherichia coli

1991 • 59 citations

Nuclear-cytoplasmic transport and VAI RNA-independent translation of influenza viral messenger RNAs in late adenovirus-infected cells

1984 • 59 citations

Stimulation of chloramphenicol acetyltransferase mRNA translation by reovirus capsid polypeptide sigma 3 in cotransfected COS cells

1989 • 58 citations

Functional dissection of adenovirus VAI RNA

1989 • 54 citations

Measures and countermeasures in the modulation of initiation factor activities by viruses.

1990 • 51 citations

Partial characterization of a cellular factor that regulates the double-stranded RNA-dependent eIF-2 alpha kinase in 3T3-F442A fibroblasts.

1991 • 46 citations

Multiple Effects of Interferon on HIV-1 Replication

1991 • 46 citations

Modified subcellular localization of interferon-induced p68 kinase during encephalomyocarditis virus infection

1990 • 43 citations

An adenovirus mutant unable to express VAI RNA displays different growth responses and sensitivity to interferon in various host cell lines.

1986 • 38 citations

Expression of cellular genes in CD4 positive lymphoid cells infected by the human immunodeficiency virus, HIV-1: Evidence for a host protein synthesis shut-off induced by cellular mRNA degradation

1990 • 38 citations

CD3-zeta surface expression is required for CD4-p56lck-mediated upregulation of T cell antigen receptor-CD3 signaling in T cells.

1992 • 37 citations

Translational Control in Influenza Virus-Infected Cells

1990 • 37 citations

Reduced Activity of the Interferon-induced Double-stranded RNA-dependent Protein Kinase during a Heat Shock Stress

1989 • 35 citations

Effect of interferon on integrity of vaccinia virus and ribosomal RNA in infected cells

1984 • 30 citations

Immunology of HIV Infection, I: Biology of the Interferons

1990 • 19 citations

Viral and cellular gene expression in CD4+ human lymphoid cell lines infected by the simian immunodeficiency virus, SIV/Mne

1991 • 18 citations

Regulation of Viral and Cellular RNA Turnover in Cells Infected by Eukaryotic Viruses including HIV-1

1990 • 17 citations

Inhibitor of Interferon‐Induced Double‐Stranded RNA‐ Dependent Protein Kinase and Its Relevance to Alteration of Cellular Protein Kinase Activity Level in Response to External Stimuli

1991 • 17 citations

The alpha subunit of eucaryotic initiation factor 2 is phosphorylated in mengovirus-infected mouse L cells

1990 • 14 citations