Diversity of cytoplasmic functions for the 3′ untranslated region of eukaryotic transcripts

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1993 • 4,021 citations

A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

1989 • 2,555 citations

The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency.

1991 • 795 citations

Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

1988 • 691 citations

A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.

1993 • 660 citations

Recognition of UGA as a selenocysteine codon in Type I deiodinase requires sequences in the 3′ untranslated region

1991 • 642 citations

A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm

1988 • 565 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

A cytoskeletal structure with associated polyribosomes obtained from HeLa cells

1977 • 530 citations

Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript.

1994 • 511 citations

Poly(A) elongation during Xenopus oocyte maturation is required for translational recruitment and is mediated by a short sequence element.

1989 • 412 citations

Messenger RNA is translated when associated with the cytoskeletal framework in normal and VSV-infected HeLa cells

1981 • 403 citations

Localization of nanos RNA controls embryonic polarity

1992 • 391 citations

RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos

1991 • 391 citations

A two-step model for the localization of maternal mRNA in Xenopus oocytes: Involvement of microtubules and microfilaments in the translocation and anchoring of Vg1 mRNA

1990 • 388 citations

mRNA poly(A) tail, a 3' enhancer of translational initiation.

1990 • 353 citations

Identification of an actin-binding protein from Dictyostelium as elongation factor 1a

1990 • 349 citations

Translational regulation and deadenylation of a protamine mRNA during spermiogenesis in the mouse

1984 • 347 citations

Translational Blockade Imposed by Cytokine-Derived UA-Rich Sequences

1989 • 347 citations

Cis- acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryos

1988 • 346 citations

Isoform-specific 3'-untranslated sequences sort alpha-cardiac and beta- cytoplasmic actin messenger RNAs to different cytoplasmic compartments [published erratum appears in J Cell Biol 1993 Dec;123(6 Pt 2):following 1907]

1993 • 332 citations

Poly(A) addition during maturation of frog oocytes: distinct nuclear and cytoplasmic activities and regulation by the sequence UUUUUAU.

1989 • 332 citations

The 3'-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation.

1994 • 330 citations

RNA on the move: the mRNA localization pathway [published erratum appears in J Cell Biol 1993 Dec;123(6 Pt 1):1625]

1993 • 315 citations

Translational regulation of nanos by RNA localization

1994 • 307 citations

Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening.

1994 • 290 citations

Vegetal Messenger RNA Localization Directed by a 340-nt RNA Sequence Element in Xenopus Oocytes

1992 • 268 citations

Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3′ untranslated region.

1994 • 267 citations

Microtubules mediate the localization of bicoid RNA during Drosophila oogenesis

1991 • 255 citations

Requirement of Microfilaments in Sorting of Actin Messenger RNA

1991 • 252 citations

Regulated polyadenylation controls mRNA translation during meiotic maturation of mouse oocytes.

1989 • 248 citations

Genetic complementation reveals a novel regulatory role for 3? untranslated regions in growth and differentiation

1993 • 245 citations

Control of the sperm–oocyte switch in Caenorhabditis elegans hermaphrodites by the fem-3 3′ untranslated region

1991 • 237 citations

Protamine 3'-untranslated sequences regulate temporal translational control and subcellular localization of growth hormone in spermatids of transgenic mice.

1989 • 235 citations

Translational control of maternal glp-1 mRNA establishes an asymmetry in the C. elegans embryo

1994 • 231 citations

The cytoskeletal framework and poliovirus metabolism

1979 • 231 citations

Mutations affecting stability and deadenylation of the yeast MFA2 transcript.

1992 • 228 citations

The Mechanisms of mRNA Degradation in Eukaryotes

1999 • 204 citations

Pumilio is essential for function but not for distribution of the Drosophila abdominal determinant Nanos.

1992 • 203 citations

Translational regulation of tra-2 by its 3′ untranslated region controls sexual identity in C. elegans

1993 • 191 citations

Circadian regulation of bioluminescence in Gonyaulax involves translational control.

1989 • 186 citations

Channeling of aminoacyl-tRNA for protein synthesis in vivo.

1991 • 182 citations

Translational initiation factor and ribosome association with the cytoskeletal framework fraction from HeLa cells

1984 • 180 citations

The 3' untranslated region of the human interferon-beta mRNA has an inhibitory effect on translation.

1987 • 177 citations

Cytochalasin releases mRNA from the cytoskeletal framework and inhibits protein synthesis.

1986 • 174 citations

Translational control during early development

1991 • 163 citations

Multiple RNA regulatory elements mediate distinct steps in localization of oskar mRNA

1993 • 162 citations

Apical localization of pair-rule transcripts requires 3′ sequences and limits protein diffusion in the Drosophila blastoderm embryo

1991 • 161 citations

Binding of a phosphoprotein to the 3' untranslated region of the mouse protamine 2 mRNA temporally represses its translation.

1993 • 157 citations

Ultrastructural visualization of cytoskeletal mRNAs and their associated proteins using double-label in situ hybridization.

1989 • 157 citations

Poly(A) RNA codistribution with microfilaments: evaluation by in situ hybridization and quantitative digital imaging microscopy.

1992 • 154 citations

In the beginning is the end: regulation of poly(A) addition and removal during early development

1990 • 153 citations

Sequences in the 3'-untranslated region of the human cellular glutathione peroxidase gene are necessary and sufficient for selenocysteine incorporation at the UGA codon

1993 • 124 citations

Discrete sequence elements control posterior pole accumulation and translational repression of maternal cyclin B RNA in Drosophila.

1993 • 118 citations

Degradation of apolipoprotein II mRNA occurs via endonucleolytic cleavage at 5′-AAU-3′/5′-UAA-3′ elements in single-stranded loop domains of the 3′-noncoding region

1989 • 118 citations

Supramolecular organization of the mammalian translation system.

1994 • 116 citations

Circular polysomes predominate on the rough endoplasmic reticulum of somatotropes and mammotropes in the rat anterior pituitary

1987 • 114 citations

Localized RNAs and their functions

1993 • 110 citations

Circadian expression of the luciferin-binding protein correlates with the binding of a protein to the 3' untranslated region of its mRNA.

1994 • 100 citations

Sequence-specific endonucleolytic cleavage and protection of mRNA in Xenopus and Drosophila.

1993 • 99 citations

Evidence for a highly selective RNA transport system and its role in establishing the dorsoventral axis of theDrosophilaegg

1992 • 96 citations

3′ non-translated sequences in Drosophila cyclin B transcripts direct posterior pole accumulation late in oogenesis and peri-nuclear association in syncytial embryos

1992 • 92 citations

The cytoskeletal framework of sea urchin eggs and embryos: Developmental changes in the association of messenger RNA

1983 • 86 citations

Processing of 9E3 mRNA and regulation of its stability in normal and Rous sarcoma virus-transformed cells.

1989 • 86 citations

Endonucleolytic cleavage of a maternal homeo box mRNA in Xenopus oocytes.

1990 • 75 citations

Endonucleolysis in the turnover of insulin-like growth factor II mRNA.

1992 • 73 citations

New genes in old sequence: a strategy for finding genes in the bacterial genome

1994 • 71 citations

Maternal mRNA from clam oocytes can be specifically unmasked in vitro by antisense RNA complementary to the 3'-untranslated region.

1990 • 70 citations

Reversal of Creatine Kinase Translational Repression by 3′ Untranslated Sequences

1990 • 69 citations

Multiple cis-acting targeting sequences are required for orb mRNA localization during Drosophila oogenesis.

1994 • 56 citations

Long-Range RNA Interaction of Two Sequence Elements Required for Endonucleolytic Cleavage of Human Insulin-Like Growth Factor II mRNAs

1995 • 55 citations

Site-specific cleavage of IGF-II mRNAs requires sequence elements from two distinct regions of the IGF-II gene

1992 • 51 citations

Recognition of the mRNA selenocysteine insertion sequence by the specialized translational elongation factor SELB.

1994 • 48 citations