Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1994 • 3,437 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

1992 • 2,527 citations

Protein modules and signalling networks

1995 • 2,447 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95

1995 • 1,861 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

1969 • 1,802 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains

1996 • 1,589 citations

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels

1991 • 1,465 citations

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

1993 • 1,455 citations

Calcium Signaling in Neurons: Molecular Mechanisms and Cellular Consequences

1995 • 1,421 citations

Glutamate neurotoxicity in cortical cell culture

1987 • 1,400 citations

Molecular diversity of the NMDA receptor channel

1992 • 1,354 citations

Changing subunit composition of heteromeric NMDA receptors during development of rat cortex

1994 • 1,342 citations

Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS

1995 • 1,239 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein

1992 • 1,180 citations

Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways

1993 • 1,165 citations

Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ

1996 • 1,127 citations

The changing landscape of ischaemic brain injury mechanisms

1999 • 1,111 citations

The Toxic Effect of Sodium L-Glutamate on the Inner Layers of the Retina

1957 • 1,061 citations

A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP

1994 • 1,039 citations

Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases

1995 • 994 citations

Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits.

1993 • 978 citations

Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions

2002 • 964 citations

Calcium: still center-stage in hypoxic-ischemic neuronal death

1995 • 921 citations

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit

1995 • 832 citations

Specific Coupling of NMDA Receptor Activation to Nitric Oxide Neurotoxicity by PSD-95 Protein

1999 • 821 citations

Glutamate neurotoxicity in cortical cell culture is calcium dependent

1985 • 818 citations

ATP receptor-mediated synaptic currents in the central nervous system

1992 • 814 citations

A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle

1987 • 786 citations

Neuronal nicotinic receptors in the human brain

2000 • 782 citations

Identification of a Site in Glutamate Receptor Subunits That Controls Calcium Permeability

1991 • 774 citations

Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases

1996 • 735 citations

Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia

1998 • 705 citations

Differences in Ca2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression

1994 • 661 citations

RNA editing of AMPA receptor subunit GluR-B: A base-paired intron-exon structure determines position and efficiency

1993 • 657 citations

Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger

1992 • 656 citations

The neurotoxicity of excitatory amino acids is produced by passive chloride influx

1985 • 634 citations

Competitive binding of α-actinin and calmodulin to the NMDA receptor

1997 • 591 citations

Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons

1993 • 569 citations

Glutamate-operated channels: Developmentally early and mature forms arise by alternative splicing

1991 • 560 citations

Role of Actin in Anchoring Postsynaptic Receptors in Cultured Hippocampal Neurons: Differential Attachment of NMDA versus AMPA Receptors

1998 • 557 citations

ATP mediates fast synaptic transmission in mammalian neurons

1992 • 549 citations

NSF Binding to GluR2 Regulates Synaptic Transmission

1998 • 542 citations

Inactivation of NMDA Receptors by Direct Interaction of Calmodulin with the NR1 Subunit

1996 • 532 citations

PDZ domains in synapse assembly and signalling

2000 • 525 citations

GKAP, a Novel Synaptic Protein That Interacts with the Guanylate Kinase-like Domain of the PSD-95/SAP90 Family of Channel Clustering Molecules

1997 • 503 citations

Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death

1994 • 496 citations

Enhanced LTP in Mice Deficient in the AMPA Receptor GluR2

1996 • 494 citations

Activity Regulates the Synaptic Localization of the NMDA Receptor in Hippocampal Neurons

1997 • 493 citations

Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses

1997 • 492 citations

Evidence for a Tetrameric Structure of Recombinant NMDA Receptors

1998 • 487 citations

Expression of Cerebellar Long-Term Depression Requires Postsynaptic Clathrin-Mediated Endocytosis

2000 • 483 citations

Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice

1994 • 479 citations

PDZ Proteins Organize Synaptic Signaling Pathways

1998 • 474 citations

Molecular mechanisms of calcium-dependent excitotoxicity

2000 • 467 citations

Neurotoxicity of excitatory amino acids

1990 • 466 citations

Importance of the Intracellular Domain of NR2 Subunits for NMDA Receptor Function In Vivo

1998 • 465 citations

In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA

2000 • 456 citations

PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands

1998 • 455 citations

Postsynaptic organisation and regulation of excitatory synapses

2000 • 452 citations

Alternatively spliced isoforms of the NMDARI receptor subunit

1995 • 450 citations

Mitochondria, Calcium Regulation, and Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

1996 • 443 citations

Synaptic Activity Mediates Death of Hypoxic Neurons

1983 • 441 citations

NMDA Receptor Heterogeneity During Postnatal Development of the Rat Brain: Differential Expression of the NR2A, NR2B, and NR2C Subunit Proteins

1997 • 439 citations

Control by Asparagine Residues of Calcium Permeability and Magnesium Blockade in the NMDA Receptor

1992 • 437 citations

N-methyl-d-aspartate promotes the survival of cerebellar granule cells in culture

1988 • 437 citations

SAP102, a Novel Postsynaptic Protein That Interacts with NMDA Receptor Complexes In Vivo

1996 • 422 citations

SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A.

1993 • 415 citations

PDZ Domains: Targeting signalling molecules to sub‐membranous sites

1997 • 411 citations

Regulation of F-Actin Stability in Dendritic Spines by Glutamate Receptors and Calcineurin

1998 • 405 citations

Nucleotide receptors

1997 • 399 citations

High actin concentrations in brain dendritic spines and postsynaptic densities.

1982 • 398 citations

Interaction of the N-Ethylmaleimide–Sensitive Factor with AMPA Receptors

1998 • 396 citations

Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein

1995 • 388 citations

LTP mechanisms: from silence to four-lane traffic

2000 • 382 citations

Cerebellar Long-Term Depression Requires PKC-Regulated Interactions between GluR2/3 and PDZ Domain–Containing Proteins

2000 • 381 citations

Enlightening the Postsynaptic Density

1997 • 381 citations

Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions

1993 • 374 citations

Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat

1988 • 370 citations

Interaction of ion channels and receptors with PDZ domain proteins

1997 • 362 citations

SAPAPs

1997 • 356 citations

The AMPA Receptor GluR2 C Terminus Can Mediate a Reversible, ATP-Dependent Interaction with NSF and α- and β-SNAPs

1998 • 355 citations

Ligand-Gated Ion Channel Interactions with Cytoskeletal and Signaling Proteins

2000 • 352 citations

Molecular mechanisms controlling calcium entry through AMPA-type glutamate receptor channels

1995 • 348 citations

Kinetics of cell lysis, dye uptake and permeability changes in cells expressing the rat P2X₇ receptor

1999 • 345 citations

Expression of a Dominant Negative Mutant of Interleukin-1β Converting Enzyme in Transgenic Mice Prevents Neuronal Cell Death Induced by Trophic Factor Withdrawal and Ischemic Brain Injury

1997 • 345 citations

PDZ Domain Suppression of an ER Retention Signal in NMDA Receptor NR1 Splice Variants

2000 • 344 citations

Cloning and Characterization of Postsynaptic Density 93, a Nitric Oxide Synthase Interacting Protein

1996 • 327 citations

Nicotinic receptor stimulation protects neurons against β‐amyloid toxicity

1997 • 320 citations

Crystal structure of a PDZ domain

1996 • 315 citations

Surface Expression of AMPA Receptors in Hippocampal Neurons Is Regulated by an NSF-Dependent Mechanism

1999 • 301 citations

Yotiao, a Novel Protein of Neuromuscular Junction and Brain That Interacts with Specific Splice Variants of NMDA Receptor Subunit NR1

1998 • 301 citations

The role of specific ions in glutamate neurotoxicity

1986 • 298 citations

Normal and Abnormal Calcium Homeostasis in Neurons: A Basis for the Pathophysiology of Traumatic and Ischemic Central Nervous System Injury

1996 • 297 citations

Protein–protein interactions: PDZ domain networks

1996 • 292 citations

Regulated Subcellular Distribution of the NR1 Subunit of the NMDA Receptor

1995 • 290 citations

Ionotropic glutamate receptor subtypes activate c-fos transcription by distinct calcium-requiring intracellular signaling pathways

1993 • 286 citations

Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons

2000 • 283 citations

Calmodulin Mediates Calcium-Dependent Inactivation of N-Methyl-D-Aspartate Receptors

1998 • 280 citations

Interactions of calmodulin and alpha-actinin with the NR1 subunit modulate Ca2+-dependent inactivation of NMDA receptors.

1999 • 279 citations

Splice Variant-Specific Interaction of the NMDA Receptor Subunit NR1 with Neuronal Intermediate Filaments

1998 • 275 citations

Molecular mechanisms of glutamate receptor clustering at excitatory synapses

1998 • 273 citations

Distinct Influx Pathways, Not Calcium Load, Determine Neuronal Vulnerability to Calcium Neurotoxicity

1998 • 270 citations

Control of Voltage-Independent Zinc Inhibition of NMDA Receptors by the NR1 Subunit

1998 • 263 citations

Single-channel conductances of NMDA receptors expressed from cloned cDNAs: comparison with native receptors

1992 • 261 citations

Mechanisms involved in irreversible anoxic damage to the in vitro rat hippocampal slice

1982 • 261 citations

EFFECTS OF CALCIUM ION CONCENTRATION ON THE DEGENERATION OF AMPUTATED AXONS IN TISSUE CULTURE

1973 • 257 citations

Ionic permeability of, and divalent cation effects on, two ATP‐gated cation channels (P2X receptors) expressed in mammalian cells.

1996 • 257 citations

PDZ domain of neuronal nitric oxide synthase recognizes novel C-terminal peptide sequences

1997 • 250 citations

Clustering Membrane Proteins: It's All Coming Together with the PSD-95/SAP90 Protein Family

1996 • 246 citations

Increased Thresholds for Long-Term Potentiation and Contextual Learning in Mice Lacking the NMDA-type Glutamate Receptor ε1 Subunit

1998 • 241 citations

Distinct Roles of Synaptic and Extrasynaptic NMDA Receptors in Excitotoxicity

2000 • 238 citations

Interactions of Calmodulin and α-Actinin with the NR1 Subunit Modulate Ca²⁺-Dependent Inactivation of NMDA Receptors

1999 • 228 citations

Structure of the NMDA Receptor Channel M2 Segment Inferred from the Accessibility of Substituted Cysteines

1996 • 228 citations

Calciseptine, a peptide isolated from black mamba venom, is a specific blocker of the L-type calcium channel.

1991 • 226 citations

Agonist-activated cobalt uptake identifies divalent cation—Permeable kainate receptors on neurons and glial cells

1991 • 214 citations

Spine Loss and Other Persistent Alterations of Hippocampal Pyramidal Cell Dendrites in a Model of Early-Onset Epilepsy

1998 • 204 citations

Na⁺‐Ca²⁺ exchanger mediates Ca²⁺ influx during anoxia in mammalian central nervous system white matter

1991 • 198 citations

Ca2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells.

1994 • 194 citations

Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule.

1994 • 190 citations

C-Terminal Truncation of NR2A Subunits Impairs Synaptic But Not Extrasynaptic Localization of NMDA Receptors

2000 • 184 citations

Alternative Splicing of the C-Terminal Domain Regulates Cell Surface Expression of the NMDA Receptor NR1 Subunit

1999 • 183 citations

The α7 nicotinic acetylcholine receptor subtype mediates nicotine protection against NMDA excitotoxicity in primary hippocampal cultures through a Ca2+ dependent mechanism

2000 • 183 citations

ATP-evoked increases in intracellular calcium in neurons and glia from the dorsal spinal cord

1994 • 177 citations

Glutamate impairs neuronal calcium extrusion while reducing sodium gradient

1994 • 172 citations

Ca2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells

1994 • 163 citations

Calcium-dependent inactivation of synaptic NMDA receptors in hippocampal neurons

1995 • 162 citations

Assembly of Proteins to Postsynaptic Densities after Transient Cerebral Ischemia

1998 • 161 citations

Comparison of quantitative calcium flux through NMDA, ATP, and ACh receptor channels

1995 • 156 citations

Kainate, N-methylaspartate and other excitatory amino acids increase calcium influx into rat brain cortex cells in vitro

1983 • 156 citations

Alteration of Ca2+ permeability and sensitivity to Mg2+ and channel blockers by a single amino acid substitution in the N-methyl-D-aspartate receptor.

1993 • 155 citations

Selective up-regulation of an nmda receptor subunit mrna in cultured cerebellar granule cells by K+-induced depolarization and nmda treatment

1994 • 153 citations

GRASP-1

2000 • 153 citations

Isoform Specificity in the Relationship of Actin to Dendritic Spines

1997 • 152 citations

Differential K + Channel Clustering Activity of PSD-95 and SAP97, Two Related Membrane-associated Putative Guanylate Kinases

1996 • 146 citations

Role of the Carboxy-Terminal Region of the GluRε2 Subunit in Synaptic Localization of the NMDA Receptor Channel

1998 • 133 citations

Organization and regulation of proteins at synapses

1999 • 130 citations

Calcium permeability and block at homomeric and heteromeric P2X₂ and P2X₃ receptors, and P2X receptors in rat nodose neurones

1998 • 126 citations

Evidence that multiple P2X purinoceptors are functionally expressed in rat supraoptic neurones

1999 • 125 citations

Adenosine triphosphate‐evoked currents in cultured neurones dissociated from rat parasympathetic cardiac ganglia.

1991 • 123 citations

Glutamate‐Induced Increase in Intracellular Ca²⁺ in Cerebral Cortex Neurons Is Transient in Immature Cells but Permanent in Mature Cells

1989 • 116 citations

Neuronal nicotinic receptors, important new players in brain function

2000 • 114 citations

Synaptic targeting of glutamate receptors

1996 • 109 citations

Activity‐dependent Regulation of N‐Methyl‐<scp>d</scp>‐aspartate Receptor Subunit Expression in Rat Cerebellar Granule Cells

1994 • 107 citations

Combinations of AMPA Receptor Subunit Expression in Individual Cortical Neurons Correlate with Expression of Specific Calcium-Binding Proteins

1997 • 105 citations

Selective activation of central subtypes of the nicotinic acetylcholine receptor has opposite effects on neonatal excitotoxic brain injuries

2002 • 102 citations

Coupling of Permeation and Gating in an NMDA-Channel Pore Mutant

1997 • 101 citations

Na⁺—Ca²⁺ Exchange Currents in Cortical Neurons: Concomitant Forward and Reverse Operation and Effect of Glutamate

1997 • 100 citations

A Direct Comparison of the Single-Channel Properties of Synaptic and Extrasynaptic NMDA Receptors

1997 • 99 citations

Attenuation of Focal Ischemic Brain Injury in Mice Deficient in the ε1 (NR2A) Subunit of NMDA Receptor

1998 • 97 citations

Transfection of N‐Methyl‐<scp>d</scp>‐Aspartate Receptors in a Nonneuronal Cell Line Leads to Cell Death

1995 • 82 citations

Vulnerability of CA1 neurons to glutamate is developmentally regulated

1996 • 80 citations

Dysfunctions in Mice by NMDA Receptor Point Mutations NR1(N598Q) and NR1(N598R)

2000 • 75 citations

Cytosolic calcium concentrations and cell death in vitro.

1996 • 74 citations

Emergence of excitotoxicity in cultured forebrain neurons coincides with larger glutamate-stimulated [Ca2+]i increases and NMDA receptor mRNA levels

1999 • 74 citations

Seizure-induced neuronal death is associated with induction of c-Jun N-terminal kinase and is dependent on genetic background

2000 • 74 citations

Nicotinic Acetylcholine Receptor Agonists Promote Survival and Reduce Apoptosis of Chick Ciliary Ganglion Neurons

2000 • 73 citations

Does neuroprotection improve stroke outcome?

1998 • 68 citations

In vivo toxicity of prion protein in murine scrapie: ultrastructural and immunogold studies

1997 • 68 citations

Cortical neurones exhibiting kainate-activated Co2+uptake are selectively vulnerable to AMPA/kainate receptor-mediated toxicity

1994 • 62 citations

Axonal Injury Alters Alternative Splicing of the Retinal NR1 Receptor: the Preferential Expression of the NR1b Isoforms Is Crucial for Retinal Ganglion Cell Survival

1998 • 58 citations

Chapter 9 Pharmacology of AMPA Antagonists and their Role in Neuroprotection

1996 • 57 citations

The Influence of Glutamate Receptor 2 Expression on Excitotoxicity in GluR2 Null Mutant Mice

2001 • 56 citations

Protein Kinase C Modulation of Recombinant NMDA Receptor Currents: Roles for the C-Terminal C1 Exon and Calcium Ions

1999 • 53 citations

Developmental expression of NMDA receptor subunits and the emergence of glutamate neurotoxicity in primary cultures of murine cerebral cortical neurons

1998 • 53 citations

Functional NMDA Receptors Are Transiently Active and Support the Survival of Purkinje Cells in Culture

1996 • 51 citations

Role of NMDA receptor functional domains in excitatory cell death

2000 • 44 citations

Nicotine exposure reduces N-methyl-D-aspartate toxicity in the hippocampus: relation to distribution of the alpha7 nicotinic acetylcholine receptor subunit.

2001 • 43 citations

Attenuation of focal cerebral infarct in mice lacking NMDA receptor subunit NR2C

1998 • 36 citations

Functional evaluation of glutamate receptor subtypes in cultured cerebellar neurones and astrocytes

1987 • 36 citations

Characterization of Excitatory Amino Acid Neurotoxicity in N‐methyl‐D‐aspartate Receptor‐deficient Mouse Cortical Neuronal Cells

1996 • 28 citations

ATP-activated cationic and anionic conductances in cultured rat hippocampal neurons

1996 • 26 citations

The contributions of GluR2 to allosteric modulation of AMPA receptors

2000 • 25 citations

Regulation of kinetic and pharmacological properties of synaptic NMDA receptors depends on presynaptic exocytosis in rat hippocampal neurones

1998 • 22 citations

Redox Sensitivity of NMDA Receptors

2003 • 17 citations

Physiological and pathological caspase cleavage of the neuronal RasGEF GRASP-1 as detected using a cleavage site-specific antibody

2002 • 16 citations

Development of intracellular calcium responses to depolarization and to kainate and in cultured mouse hippocampal neurons

1991 • 15 citations