The α7 nicotinic acetylcholine receptor subtype mediates nicotine protection against NMDA excitotoxicity in primary hippocampal cultures through a Ca2+ dependent mechanism

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.

1987 • 3,809 citations

Calcium - a life and death signal

1998 • 2,040 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

1993 • 1,455 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Presynaptic nicotinic ACh receptors

1997 • 1,313 citations

Mitochondria and Neuronal Survival

2000 • 1,206 citations

The Diversity of Neuronal Nicotinic Acetylcholine Receptors

1993 • 1,040 citations

β-Amyloid1–42 Binds to α7 Nicotinic Acetylcholine Receptor with High Affinity

2000 • 781 citations

Nicotinic Receptors in the Development and Modulation of CNS Synapses

1996 • 771 citations

A Practical Guide to the Preparation of Ca2+ Buffers

1994 • 753 citations

Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons

1993 • 569 citations

Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes.

1993 • 543 citations

Regulation of NMDA channel function by endogenous Ca2+-dependent phosphatase

1994 • 483 citations

Nicotinic receptors in the brain: correlating physiology with function

1999 • 450 citations

Single Synaptic Events Evoke NMDA Receptor–Mediated Release of Calcium from Internal Stores in Hippocampal Dendritic Spines

1999 • 437 citations

Synaptic Desensitization of NMDA Receptors by Calcineurin

1995 • 404 citations

Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration

1993 • 396 citations

Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium

1993 • 394 citations

Cigarette smoking and protection from Parkinson's disease

1995 • 372 citations

Calcium influx through nicotinic receptor in rat central neurons: Its relevance to cellular regulation

1992 • 328 citations

Nicotinic receptor stimulation protects neurons against β‐amyloid toxicity

1997 • 320 citations

Neuronal nicotinic acetylcholine receptors as novel drug targets.

2000 • 284 citations

Distinct Influx Pathways, Not Calcium Load, Determine Neuronal Vulnerability to Calcium Neurotoxicity

1998 • 270 citations

Nicotine Prevents Experimental Parkinsonism in Rodents and Induces Striatal Increase of Neurotrophic Factors

1998 • 218 citations

Neuronal nicotinic receptors : pharmacology and therapeutic opportunities

1999 • 203 citations

Relation between nicotine intake and Alzheimer's disease.

1991 • 199 citations

Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via α7-neuronal receptors and neuronal CNS receptors

1997 • 193 citations

Stimulation of α4β2 nicotinic acetylcholine receptors inhibits β-amyloid toxicity

1998 • 192 citations

Comparison of quantitative calcium flux through NMDA, ATP, and ACh receptor channels

1995 • 156 citations

An autoradiographic study of the distribution of binding sites for the novel α7‐selective nicotinic radioligand [³H]‐methyllycaconitine in the mouse brain

1999 • 125 citations

Synaptic-type acetylcholine receptors raise intracellular calcium levels in neurons by two mechanisms

1994 • 123 citations

Calcium and neuronal death

2005 • 112 citations

Nicotine protects cultured striatal neurones against N-methyl-D-aspartate receptor-mediated neurotoxicity

1994 • 112 citations

Characterization of the neuroprotective and toxic effects of α7 nicotinic receptor activation in PC12 cells

1999 • 107 citations

In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418

1996 • 105 citations

Nicotine blocks TNF-?-mediated neuroprotection to NMDA by an ?-bungarotoxin-sensitive pathway

1998 • 104 citations

α-Bungarotoxin binding sites in rat hippocampal and cortical cultures: initial characterisation, colocalisation with α7 subunits and up-regulation by chronic nicotine treatment

1995 • 103 citations

Calcium mobilization elicited by two types of nicotinic acetylcholine receptors in mouse substantia nigra pars compacta

2000 • 97 citations

Nicotine modulates the neurotoxic effect of β-amyloid protein(25–35) in hippocampal cultures

1997 • 83 citations

Acute intermittent nicotine treatment produces regional increases of basic fibroblast growth factor messenger RNA and protein in the tel- and diencephalon of the rat

1998 • 81 citations

Nicotinic Acetylcholine Receptor Agonists Promote Survival and Reduce Apoptosis of Chick Ciliary Ganglion Neurons

2000 • 73 citations

Multiple Ca²⁺ signaling pathways converge on CaM kinase in PC12 cells

1992 • 71 citations

Nicotine rescues PC12 cells from death induced by nerve growth factor deprivation

1996 • 71 citations

In Vivo Protection against NMDA-induced Neurodegeneration by MK-801 and Nimodipine: Combined Therapy and Temporal Course of Protection

1996 • 59 citations

Nicotine increases intracellular calcium in rat hippocampal neurons via voltage-gated calcium channels

1995 • 55 citations

(-)-Nicotine Protects against Systemic Kainic Acid-Induced Excitotoxic Effects

1995 • 47 citations

Chronic nicotine intake decelerates aging of nigrostriatal dopaminergic neurons

1994 • 39 citations

Nicotine protects against the dexamethasone potentiation of kainic acid-induced neurotoxicity in cultured hippocampal neurons

1996 • 26 citations

Histological and Behavioral Protection by (−)-Nicotine against Quinolinic Acid-Induced Neurodegeneration in the Hippocampus

1998 • 22 citations