Distinct Influx Pathways, Not Calcium Load, Determine Neuronal Vulnerability to Calcium Neurotoxicity

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1997 • 1,533 citations

Ca2 ⁺ Permeability of KA-AMPA—Gated Glutamate Receptor Channels Depends on Subunit Composition

1991 • 1,458 citations

Glutamate neurotoxicity in cortical cell culture

1987 • 1,400 citations

NMDA-dependent superoxide production and neurotoxicity

1993 • 1,188 citations

Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways

1993 • 1,165 citations

Nonvesicular release of neurotransmitter

1993 • 837 citations

Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate

1995 • 779 citations

Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons

1993 • 569 citations

The double-edged role of nitric oxide in brain function and superoxide-mediated injury.

1991 • 471 citations

Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations.

1992 • 449 citations

Extrasynaptic Glutamate Spillover in the Hippocampus: Dependence on Temperature and the Role of Active Glutamate Uptake

1997 • 425 citations

Mobile and immobile calcium buffers in bovine adrenal chromaffin cells.

1993 • 418 citations

GLUTAMATE-INDUCED NEURONAL NECROSIS IN THE INFANT MOUSE HYPOTHALAMUS

1971 • 409 citations

Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations

1990 • 343 citations

The Quantity of Calcium that Appears to Induce Neuronal Death

1994 • 167 citations

Ca²⁺-Permeable AMPA/Kainate and NMDA Channels: High Rate of Ca²⁺Influx Underlies Potent Induction of Injury

1996 • 156 citations

Kainate receptor subunits expressed in single cultured hippocampal neurons: Molecular and functional variants by RNA editing

1995 • 141 citations

Excitotoxic degeneration is initiated at non-random sites in cultured rat cerebellar neurons

1995 • 118 citations

Molecular aspects of tetanus and botulinum neurotoxin poisoning

1995 • 105 citations

Excitotoxic activation of the NMDA receptor results in inhibition of calcium/calmodulin kinase II activity in cultured hippocampal neurons

1995 • 77 citations

Cortical neurones exhibiting kainate-activated Co2+uptake are selectively vulnerable to AMPA/kainate receptor-mediated toxicity

1994 • 62 citations

Calcium-calmodulin regulated effectors of microtubule stability in bovine brain

1992 • 57 citations

Calcium dependency of n-methyl-d-aspartate toxicity in slices from the immature rat hippocampus

1989 • 49 citations

Ultrastructural damage and neuritic beading in cold-stressed spinal neurons with comparisons to NMDA and A23187 toxicity

1995 • 40 citations

Determinants of the calcium permeation of ligand-gated cation channels

1992 • 20 citations