Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Caspases: Enemies Within

1998 • 6,923 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 • 2,054 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1998 • 872 citations

Substrate Specificities of Caspase Family Proteases

1997 • 871 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 826 citations

Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity

1996 • 768 citations

Pro-caspase-3 Is a Major Physiologic Target of Caspase-8

1998 • 743 citations

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models

1995 • 604 citations

Oxidative Stress, Thiol Reagents, and Membrane Potential Modulate the Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the Adenine Nucleotide Translocase

1997 • 588 citations

Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex

1996 • 540 citations

Membrane potential can be determined in individual cells from the nernstian distribution of cationic dyes

1988 • 505 citations

Bcl-xL Prevents Cell Death following Growth Factor Withdrawal by Facilitating Mitochondrial ATP/ADP Exchange

1999 • 496 citations

Mitochondria, Calcium Regulation, and Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

1996 • 443 citations

Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.

1996 • 411 citations

Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore

1996 • 336 citations

Caspases Induce Cytochrome c Release from Mitochondria by Activating Cytosolic Factors

1999 • 302 citations

[6] Preparation of synaptic and nonsynaptic mitochondria from mammalian brain

1979 • 294 citations

Mitochondria in Neurodegeneration: Bioenergetic Function in Cell Life and Death

1999 • 294 citations

Evidence of a Novel Event during Neuronal Death

1998 • 276 citations

Staurosporine-Induced Neuronal Apoptosis

1995 • 248 citations

Mitochondrial permeability transition triggers lymphocyte apoptosis.

1996 • 238 citations

Calcineurin and mitochondrial function in glutamate‐induced neuronal cell death

1996 • 234 citations

Mechanisms of Reduced Striatal NMDA Excitotoxicity in Type I Nitric Oxide Synthase Knock-Out Mice

1997 • 186 citations

Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones.

1997 • 185 citations

Mitochondrial Depolarization Is Not Required for Neuronal Apoptosis

1999 • 184 citations

Role of Caspases in N‐Methyl‐<scp>d</scp>‐Aspartate‐Induced Apoptosis in Cerebrocortical Neurons

1998 • 170 citations

Staurosporine-Induced Apoptosis of Cultured Rat Hippocampal Neurons Involves Caspase-1-Like Proteases as Upstream Initiators and Increased Production of Superoxide as a Main Downstream Effector

1998 • 164 citations

Cytochrome c release from brain mitochondria is independent of the mitochondrial permeability transition

1998 • 144 citations

Intracellular calcium levels during the period of delayed excitotoxicity

1993 • 132 citations

Phenotypic expression of the DYT1 mutation: A family with writer's cramp of juvenile onset

1998 • 131 citations

Detection of apoptosis in live cells by MitoTracker? Red CMXRos and SYTO dye flow cytometry

1997 • 122 citations

Programmed cell death: Does it play a role in parkinson's disease?

1998 • 103 citations

Changes in membrane potential during calcium ion influx and efflux across the mitochondrial membrane

1978 • 89 citations

Similarity of Neuronal Cell Injury and Death in AIDS Dementia and Focal Cerebral Ischemia: Potential Treatment with NMDA Open‐Channel Blockers and Nitric Oxide‐Related Species

1996 • 88 citations

Calcium and pH in Anoxic and Toxic Injury

1990 • 82 citations

On the inhibition of the adenine nucleotide translocation by bongkrekic acid

1970 • 71 citations