Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

1992 • 2,527 citations

The regulation and function of c-fos and other immediate early genes in the nervous system

1990 • 2,392 citations

CREB: a Ca ²⁺ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases

1991 • 1,476 citations

Multiple types of neuronal calcium channels and their selective modulation

1988 • 1,399 citations

Molecular diversity of the NMDA receptor channel

1992 • 1,354 citations

PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS

1991 • 1,078 citations

Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB

1990 • 1,061 citations

Excitotoxity and the NMDA receptor

1987 • 1,053 citations

Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation

1989 • 1,014 citations

Role of ion flux in the control of c-fos expression

1986 • 1,006 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Regulation of brain Type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: A Ca2+-triggered molecular switch

1986 • 856 citations

Regulation of CREB Phosphorylation in the Suprachiasmatic Nucleus by Light and a Circadian Clock

1993 • 817 citations

Stimulation of Neuronal Acetylcholine Receptors Induces Rapid Gene Transcription

1986 • 761 citations

NEURONAL Ca²⁺/CALMODULIN-DEPENDENT PROTEIN KINASES

1992 • 713 citations

Differential expression of immediate early genes in the hippocampus and spinal cord

1990 • 670 citations

KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.

1990 • 630 citations

Calcium ions, active zones and synaptic transmitter release

1988 • 609 citations

Control of postsynaptic Ca2+ influx in developing neocortex by excitatory and inhibitory neurotransmitters

1991 • 599 citations

cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinase.

1991 • 552 citations

Calcium transport and buffering in neurons

1988 • 519 citations

Clustering of L-type Ca2+ channels at the base of major dendrites in hippocampal pyramidal neurons

1990 • 512 citations

Dendritic spines as individual neuronal compartments for synaptic Ca2+ responses

1991 • 487 citations

Stimulation of Protein Tyrosine Phosphorylation by NMDA Receptor Activation

1991 • 464 citations

L-type voltage-sensitive calcium channels mediate synaptic activation of immediate early genes

1991 • 429 citations

The control of neuronal Ca2+ homeostasis

1991 • 418 citations

Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences.

1988 • 404 citations

Subcellular Calcium Transients Visualized by Confocal Microscopy in a Voltage-Clamped Vertebrate Neuron

1990 • 341 citations

Expression of a multifunctional Ca2+/calmodulin-dependent protein kinase and mutational analysis of its autoregulation

1989 • 293 citations

The SRE: a growth factor responsive transcriptional regulator.

1990 • 287 citations

Independent regulation of calcium revealed by imaging dendritic spines

1991 • 272 citations

Ca2+ channels: diversity of form and function

1992 • 269 citations

Optical imaging of calcium accumulation in hippocampal pyramidal cells during synaptic activation

1989 • 265 citations

R 24 571: A potent inhibitor of calmodulin-activated enzymes

1981 • 241 citations

In primary cultures of cerebellar granule cells the activation of N-methyl-D-aspartate-sensitive glutamate receptors induces c-fos mRNA expression.

1989 • 236 citations

Postsynaptic NMDA receptor-mediated calcium accumulation in hippocampal CAl pyramidal cell dendrites

1990 • 234 citations

Dantrolene Prevents Glutamate Cytotoxicity and Ca²⁺ Release from Intracellular Stores in Cultured Cerebral Cortical Neurons

1991 • 232 citations

Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter.

1989 • 220 citations

A 42-kD tyrosine kinase substrate linked to chromaffin cell secretion exhibits an associated MAP kinase activity and is highly related to a 42-kD mitogen-stimulated protein in fibroblasts.

1990 • 142 citations

Autophosphorylation of type II Ca2+/calmodulin-dependent protein kinase in cultures of postnatal rat hippocampal slices.

1991 • 134 citations

Inhibition of voltage-gated Ca2+ channels and insulin secretion in HIT cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-62: comparison with antagonists of calmodulin and L-type Ca2+ channels.

1992 • 124 citations

Activation of multifunctional Ca2+/calmodulin-dependent kinase in intact hippocampal slices

1991 • 115 citations

Trans-synaptic regulation of gene expression

1992 • 104 citations

Ca2+/calmodulin kinase is activated by the phosphatidylinositol signaling pathway and becomes Ca2(+)-independent in PC12 cells.

1990 • 98 citations

Autophosphorylation and activation of Ca2+/calmodulin-dependent protein kinase II in intact nerve terminals.

1988 • 81 citations

Interaction of calmodulin inhibitors and protein kinase C inhibitors with voltage-dependent calcium channels

1987 • 65 citations

Lipopolyamine‐Mediated Transfection Allows Gene Expression Studies in Primary Neuronal Cells

1990 • 63 citations

Synaptic plasticity: long-term potentiation in the hippocampus

1992 • 33 citations

Modulation of calcium current by calmodulin antagonists

1988 • 30 citations

Exocytosis and its control at the synapse

1992 • 17 citations