Expression of a Dominant Negative Mutant of Interleukin-1β Converting Enzyme in Transgenic Mice Prevents Neuronal Cell Death Induced by Trophic Factor Withdrawal and Ischemic Brain Injury

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

Structure and mechanism of interleukin-lβ converting enzyme

1994 • 842 citations

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1993 • 703 citations

Prevention of Vertebrate Neuronal Death by the crmA Gene

1994 • 618 citations

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

1992 • 547 citations

The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death

1990 • 533 citations

Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain

1993 • 481 citations

Interleukin 1 is processed and released during apoptosis.

1991 • 459 citations

Reduced Brain Edema and Infarction Volume in Mice Lacking the Neuronal Isoform of Nitric Oxide Synthase after Transient MCA Occlusion

1996 • 422 citations

Transgenic mice expressing β-galactosidase in mature neurons under neuron-specific enolase promoter control

1990 • 360 citations

Interleukin-1 beta mRNA expression in ischemic rat cortex.

1993 • 335 citations

Peptide inhibitors of the ice protease family arrest programmed cell death of motoneurons in vivo and in vitro

1995 • 324 citations

bcl-2 transgene expression can protect neurons against developmental and induced cell death.

1995 • 261 citations

Rapid Communication: Regional Variability in DNA Fragmentation After Global Ischemia Evidenced by Combined Histological and Gel Electrophoresis Observations in the Rat Brain

1993 • 235 citations

Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway.

1995 • 222 citations

Endonuclease activation following focal ischemic injury in the rat brain

1993 • 211 citations

Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri.

1994 • 209 citations

DNA damage consistent with apoptosis in transient focal ischaemic neocortex

1994 • 198 citations

Functional role of interleukin 1 beta (IL-1 beta) in IL-1 beta-converting enzyme-mediated apoptosis.

1996 • 185 citations

In situ detection of DNA fragmentation after focal cerebral ischemia in mice

1995 • 137 citations

Interleukin-1 beta converting enzyme requires oligomerization for activity of processed forms in vivo.

1995 • 133 citations

Molecular control of life and death

1995 • 95 citations

Molecular and cellular aspects of patterning sensory neurone connections in the vertebrate nervous system

1987 • 94 citations