Nucleotide receptors

The Cytolytic P _2Z Receptor for Extracellular ATP Identified as a P _2X Receptor (P2X ₇ )

1996 • 1,703 citations

Extracellular ATP: effects, sources and fate

1986 • 1,666 citations

Is there a basis for distinguishing two types of P2-purinoceptor?

1985 • 1,353 citations

A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

1997 • 990 citations

Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons

1995 • 988 citations

New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor

1994 • 924 citations

Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels

1996 • 882 citations

ATP receptor-mediated synaptic currents in the central nervous system

1992 • 814 citations

Expression cloning of an ATP receptor from mouse neuroblastoma cells.

1993 • 587 citations

Cloning and functional expression of a brain G‐protein‐coupled ATP receptor

1993 • 545 citations

The Permeabilizing ATP Receptor, P2X7

1997 • 486 citations

Tissue distribution of the P2X7 receptor

1997 • 481 citations

Release of acetylcholine at voluntary motor nerve endings

1936 • 480 citations

Distinct ATP receptors on pain-sensing and stretch-sensing neurons

1997 • 452 citations

Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals

1997 • 418 citations

Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy.

1994 • 410 citations

Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry.

1996 • 405 citations

An antagonist-insensitive P2X receptor expressed in epithelia and brain.

1996 • 404 citations

The P2Z purinoceptor: an intriguing role in immunity, inflammation and cell death

1995 • 378 citations

P2X4: an ATP-activated ionotropic receptor cloned from rat brain.

1996 • 339 citations

Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation.

1996 • 328 citations

Pharmacology and electrophysiology of ATP-activated ion channels

1992 • 326 citations

Drug receptors and the inhibition of nerve cells

1989 • 308 citations

Mouse microglial cells express a plasma membrane pore gated by extracellular ATP.

1996 • 305 citations

The P2Y₁ receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells

1997 • 294 citations

A P2X purinoceptor cDNA conferring a novel pharmacological profile

1995 • 279 citations

Cloning, Functional Expression and Tissue Distribution of the Human P2Y6Receptor

1996 • 255 citations

Molecular Cloning and Functional Analysis of a Novel P2 Nucleotide Receptor

1995 • 254 citations

Cloning and Functional Expression of a Human Uridine Nucleotide Receptor

1995 • 250 citations

Second messenger cascade specificity and pharmacological selectivity of the human P_2Y1‐purinoceptor

1996 • 248 citations

Isolated rat hepatocytes can signal to other hepatocytes and bile duct cells by release of nucleotides.

1996 • 225 citations

Characterization of Recombinant Human P2X₄ Receptor Reveals Pharmacological Differences to the Rat Homologue

1997 • 220 citations

Activation of Receptor-operated Cation Channels via P2X1 Not P2T Purinoceptors in Human Platelets

1996 • 213 citations

Identification of amino acid residues contributing to the pore of a P2X receptor

1997 • 207 citations

Cloning, Expression, and Chromosomal Localization of the Human Uridine Nucleotide Receptor Gene

1995 • 193 citations

A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain

1996 • 188 citations

P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation.

1996 • 183 citations

Molecular architecture of G protein-coupled receptors

1996 • 178 citations

Expression of a cloned P2Y purinergic receptor that couples to phospholipase C.

1994 • 177 citations

How should P2x purinoceptors be classified pharmacologically?

1995 • 163 citations

Desensitization of the P2X₂ receptor controlled by alternative splicing

1997 • 160 citations

Cloning of Rat and Mouse P2Y Purinoceptors

1995 • 158 citations

Families of ion channels with two hydrophobic segments

1996 • 150 citations

Site-directed Mutagenesis of P2U Purinoceptors

1995 • 148 citations

Localization and Functional Expression of Splice Variants of the P2X₂Receptor

1997 • 140 citations

Domains of P2X receptors involved in desensitization

1996 • 140 citations

Cloning and Chromosomal Localization of the Human P2Y1 Purinoceptor

1996 • 139 citations

Molecular Cloning of a Novel P2 Purinoceptor from Human Erythroleukemia Cells

1996 • 134 citations

Early Expression of a Novel Nucleotide Receptor in the Neural Plate of Xenopus Embryos

1997 • 131 citations

ATP Serves as a Negative Feedback Inhibitor of Voltage-Gated Ca2+ Channel Currents in Cultured Bovine Adrenal Chromaffin Cells

1996 • 127 citations

Identification of 6H1 as a P2YPurinoceptor: P2Y5

1996 • 127 citations

Molecular cloning and functional expression of a novel rat heart P2X purinoceptor

1996 • 126 citations

Synchronous release of ATP and neurotransmitter within milliseconds of a motor nerve impulse in the frog.

1996 • 122 citations

Regulation of rhythmic movements by purinergic neurotransmitters in frog embryos

1996 • 119 citations

Characterization and chromosomal localization of a human P2X receptor from the urinary bladder.

1995 • 117 citations

Cloning and Characterization of a Bovine P2Y Receptor ∮

1995 • 114 citations

Cloning and Tissue Distribution of a Novel P2X Receptor from Rat Brain

1996 • 109 citations

The P2Y purinoceptor in rat brain microvascular endothelial cells couple to inhibition of adenylate cyclase

1996 • 107 citations

Molecular characterization and pharmacological properties of the human P2X3 purinoceptor

1997 • 105 citations

P2X purinoceptors in cultured myenteric neurons of guinea‐pig small intestine.

1996 • 101 citations

A novel G protein-coupled P2 purinoceptor (P2Y3) activated preferentially by nucleoside diphosphates.

1996 • 100 citations

Characterization of a P_2X‐purinoceptor in cultured neurones of the rat dorsal root ganglia

1996 • 97 citations

ATP-induced membrane currents in ameboid microglia acutely isolated from mouse brain slices

1996 • 97 citations

Cloning and Pharmacological Characterization of a Fourth P2X Receptor Subtype Widely Expressed in Brain and Peripheral Tissues Including Various Endocrine Tissues

1996 • 94 citations

Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor

1996 • 93 citations

Cloned and transfected P2Y₄ receptors: characterization of a suramin and PPADS‐insensitive response to UTP

1996 • 89 citations

Characterisation of a recombinant P2Y purinoceptor

1995 • 85 citations

Transient up-regulation of P2Y₂nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes

1997 • 85 citations

P2X1 receptor activation in HL60 cells

1996 • 81 citations

P_2x‐purinoceptors of myenteric neurones from the guinea‐pig ileum and their unusual pharmacological properties

1996 • 76 citations

Modelling the P2Y purinoceptor using rhodopsin as template.

1995 • 76 citations

Identification of a Short Form of the P2xR1-Purinoceptor Subunit Produced by Alternative Splicing in the Pituitary and Cochlea

1995 • 76 citations

P2 purinoceptor‐mediated depolarization of rat supraoptic neurosecretory cells in vitro.

1995 • 75 citations

ATP activates non‐selective cation channels and calcium release in inner hair cells of the guinea‐pig cochlea.

1996 • 73 citations

Discrimination by PPADS between endothelial P_2Y‐ and P_2U‐ purinoceptors in the rat isolated mesenteric arterial bed

1996 • 70 citations

Central noradrenergic neurons signal via atp to elicit vasopressin responses to haemorrhage

1996 • 68 citations

Proton potentiation of ATP-gated ion channel responses to ATP and Zn2+ in rat nodose ganglion neurons

1996 • 65 citations

An ATP-activated, ligand-gated ion channel on a cholinergic presynaptic nerve terminal.

1996 • 65 citations

ATP‐gated cation channels (P2X purinoceptors) in trigeminal mesencephalic nucleus neurons of the rat.

1997 • 64 citations

Pharmacological characterization of P2 purinoceptor types in rat locus coeruleus neurons

1996 • 54 citations

Identification of potent P_2Y‐purinoceptor agonists that are derivatives of adenosine 5′‐monophosphate

1996 • 50 citations

Variation in expression of the outer hair cell P2X receptor conductance along the guinea‐pig cochlea.

1997 • 48 citations

Purinoceptor function in the immune system

1996 • 46 citations

Identification of a G protein coupled receptor induced in activated T cells.

1993 • 45 citations

ATP, a partial agonist of atypical P_2y purinoceptors in rat brain microvascular endothelial cells

1995 • 41 citations

Enhancement of ATP-activated current by protons in dorsal root ganglion neurons

1997 • 41 citations

Distribution of [35S]dATPαS binding sites in the adult rat neuraxis

1997 • 39 citations

Molecular cloning and functional characterization of a rat pituitary G protein-coupled adenosine triphosphate (ATP) receptor

1996 • 39 citations

A comparison of the binding characteristics of recombinant P_2×1 and P_2×2 purinoceptors

1996 • 36 citations

Characterization of a P_2Y Purinoceptor in the Brain

1995 • 36 citations

P2Purinoceptor-Operated Potassium Channel in Rat Cerebellar Neurons

1996 • 35 citations

The binding characteristics of a human bladder recombinant P_2X purinoceptor, labelled with [³H]‐αβmeATP, [³⁵S]‐ATPγS or ³³[P]‐ATP

1996 • 34 citations

An ATP‐gated cation channel with some P2Z‐like characteristics in gastric smooth muscle cells of toad.

1997 • 33 citations

Activation of the muscarinic K+ channel by P2‐purinoceptors via pertussis toxin‐sensitive G proteins in guinea‐pig atrial cells.

1996 • 33 citations

Inhibition by heterologously‐expressed P2Y₂ nucleotide receptors of N‐type calcium currents in rat sympathetic neurones

1997 • 32 citations

Modulation by purines of calcium‐activated non‐selective cation channels in the outer hair cells of the guinea‐pig cochlea.

1996 • 31 citations

Activation of Nucleotide Receptors Inhibits High‐threshold Calcium Currents in NG108‐15 Neuronal Hybrid Cells

1996 • 29 citations

Functional evidence for multiple purinoceptor subtypes in the rat medial vestibular nucleus

1997 • 27 citations

ATP-activated cationic and anionic conductances in cultured rat hippocampal neurons

1996 • 26 citations

Purinergic cation channels in neurons of rabbit vesical parasympathetic ganglia

1996 • 18 citations

The Diverse Series of Recombinant P2Y Purinoceptors

2007 • 17 citations

Fading and rebound of currents induced by ATP in PC12 cells

1996 • 15 citations