Homeostasis of memory T cells

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

2003 • 3,104 citations

TLR signaling pathways

2004 • 2,359 citations

Immunological Memory and Protective Immunity: Understanding Their Relation

1996 • 1,771 citations

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

2000 • 1,596 citations

Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

2000 • 1,578 citations

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

1994 • 1,423 citations

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

1998 • 1,293 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

2003 • 1,226 citations

Age-related changes in lymphocyte development and function

2004 • 1,164 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

IL-7 is critical for homeostatic proliferation and survival of naïve T cells

2001 • 940 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

IL-15Rα Recycles and Presents IL-15 In trans to Neighboring Cells

2002 • 877 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

Control of Homeostasis of CD8 ⁺ Memory T Cells by Opposing Cytokines

2000 • 847 citations

Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes

2006 • 843 citations

Memory CD8 T-Cell Differentiation during Viral Infection

2004 • 841 citations

Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells

2002 • 783 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice

1999 • 738 citations

THE MULTIFACETED REGULATION OF INTERLEUKIN-15 EXPRESSION AND THE ROLE OF THIS CYTOKINE IN NK CELL DIFFERENTIATION AND HOST RESPONSE TO INTRACELLULAR PATHOGENS

1999 • 712 citations

Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells

2002 • 671 citations

Cytotoxic T-cell memory without antigen

1994 • 669 citations

Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation

2000 • 644 citations

Central tolerance: learning self-control in the thymus

2005 • 641 citations

Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory

2001 • 600 citations

Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells

2002 • 588 citations

Low-Affinity Ligands for the TCR Drive Proliferation of Mature CD8+ T Cells in Lymphopenic Hosts

1999 • 548 citations

Response of naïve and memory CD8+ T cells to antigen stimulation in vivo

2000 • 542 citations

T Cell Memory

2002 • 529 citations

Homeostasis-Stimulated Proliferation Drives Naive T Cells to Differentiate Directly into Memory T Cells

2000 • 527 citations

Cutting Edge: Requirement for IL-15 in the Generation of Primary and Memory Antigen-Specific CD8 T Cells

2002 • 519 citations

ON IMMUNOLOGICAL MEMORY

1996 • 482 citations

Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells

2003 • 454 citations

Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells

2003 • 449 citations

Class II-Independent Generation of CD4 Memory T Cells from Effectors

1999 • 422 citations

IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice

2000 • 419 citations

The Interleukin-2 Receptor γ Chain: Its Role in the Multiple Cytokine Receptor Complexes and T Cell Development in XSCID

1996 • 411 citations

Lymphocyte life-span and memory

1994 • 405 citations

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

2003 • 384 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

Coordinate Expression and Trans Presentation of Interleukin (IL)-15Rα and IL-15 Supports Natural Killer Cell and Memory CD8+ T Cell Homeostasis

2004 • 364 citations

Fatal Leukemia in Interleukin 15 Transgenic Mice Follows Early Expansions in Natural Killer and Memory Phenotype Cd8+ T Cells

2001 • 362 citations

Cytokines and immunodeficiency diseases: critical roles of the γ_c‐dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways

2004 • 357 citations

Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes.

1993 • 352 citations

Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands

1999 • 341 citations

T Cell Stimulation In Vivo by Lipopolysaccharide (LPS)

1997 • 335 citations

Interleukin 15 Controls both Proliferation and Survival of a Subset of Memory-Phenotype CD8+ T Cells

2002 • 332 citations

Induction and regulation of IL-15 expression in murine macrophages.

1996 • 327 citations

IL-15 Promotes the Survival of Naive and Memory Phenotype CD8+ T Cells

2003 • 323 citations

Designing and Maintaining the Mature TCR Repertoire

1999 • 323 citations

γ chain required for naïve CD4+ T cell survival but not for antigen proliferation

2000 • 314 citations

Overexpression of Interleukin (IL)-7 Leads to IL-15–independent Generation of Memory Phenotype CD8+ T Cells

2002 • 291 citations

Is T-cell memory maintained by crossreactive stimulation?

1990 • 253 citations

CD25+CD4+ T cells contribute to the control of memory CD8+ T cells

2002 • 241 citations

Lymphocyte lifespans: homeostasis, selection and competition

1993 • 226 citations

How αβ T cells deal with induced TCRα ablation

2001 • 224 citations

The thymus and negative selection

2002 • 216 citations

Following the Development of a CD4 T Cell Response In Vivo

1999 • 213 citations

Distinct Effects of STAT5 Activation on CD4+ and CD8+ T Cell Homeostasis: Development of CD4+CD25+ Regulatory T Cells versus CD8+ Memory T Cells

2003 • 207 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

1997 • 204 citations

IL-7 regulates basal homeostatic proliferation of antiviral CD4 ⁺ T cell memory

2004 • 197 citations

The long-term maintenance of cytotoxic T cell memory does not require persistence of antigen.

1994 • 190 citations

CD4+ T cell effectors can become memory cells with high efficiency and without further division

2001 • 186 citations

Autonomous activation of B and T cells in antigen-free mice

1986 • 184 citations

Impairment of immunological memory in the absence of MHC despite survival of memory T cells

2002 • 181 citations

T Cell–Independent Interleukin 15rα Signals Are Required for Bystander Proliferation

2001 • 174 citations

IL-15Rα expression on CD8⁺T cells is dispensable for T cell memory

2003 • 160 citations

Differential Roles of Interleukin 15 mRNA Isoforms Generated by Alternative Splicing in Immune Responses in Vivo

2000 • 153 citations

The life span of naive alpha/beta T cells in secondary lymphoid organs.

1993 • 130 citations

Positive selection of thymocytes bearing αβ T cell receptors

1997 • 124 citations

Cytokine-driven proliferation and differentiation of human naïve, central memory and effector memory CD4+ T cells

2003 • 115 citations

IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus macaques

2004 • 105 citations

The Involvement of the Intestinal Microflora in the Expansion of CD4+ T Cells with a-Naive Phenotype in the Periphery

1992 • 101 citations

Plasticity of T Cell Memory Responses to Viruses

2004 • 99 citations

SOCS-1 regulates IL-15–driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential

2005 • 87 citations

Are Major Histocompatibility Complex Molecules Involved in the Survival of Naive CD4+ T Cells?

2003 • 76 citations

Suppressor of Cytokine Signaling 1 Regulates IL-15 Receptor Signaling in CD8+CD44high Memory T Lymphocytes

2003 • 71 citations

Reverse Signaling through Membrane-bound Interleukin-15

2004 • 63 citations

On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4 ⁺ T cells

2003 • 60 citations

An anti-IL-2 antibody increases serum halflife and improves anti-tumor efficacy of human recombinant interleukin-2

1994 • 52 citations

Stimulation of memory T cells by cytokines

2000 • 48 citations

Mice deprived of exogenous antigenic stimulation develop a normal repertoire of functional T cells.

1992 • 35 citations

Enhancement of anti-tumor activity of recombinant interleukin-2 (rIL-2) by immunocomplexing with a monoclonal antibody against rIL-2

1993 • 28 citations

Evidence of a Novel IL-2/15Rβ-Targeted Cytokine Involved in Homeostatic Proliferation of Memory CD8+ T Cells

2004 • 25 citations