CD4+ T cell effectors can become memory cells with high efficiency and without further division

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Immunological Memory and Protective Immunity: Understanding Their Relation

1996 • 1,771 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

T CELL MEMORY

1998 • 863 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Control of Homeostasis of CD8 ⁺ Memory T Cells by Opposing Cytokines

2000 • 847 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Response of naïve and memory CD8+ T cells to antigen stimulation in vivo

2000 • 542 citations

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis

1997 • 460 citations

Antigen-Specific Development of Primary and Memory T Cells in Vivo

1995 • 444 citations

Class II-Independent Generation of CD4 Memory T Cells from Effectors

1999 • 422 citations

Linear Differentiation of Cytotoxic Effectors into Memory T Lymphocytes

1999 • 393 citations

Designing and Maintaining the Mature TCR Repertoire

1999 • 323 citations

Modelling T-cell memory by genetic marking of memory T cells in vivo

1999 • 310 citations

Qualitative Changes Accompany Memory T Cell Generation: Faster, More Effective Responses at Lower Doses of Antigen

2000 • 285 citations

Generation and in vivo persistence of polarized Th1 and Th2 memory cells

1994 • 283 citations

Attrition of T Cell Memory

1999 • 278 citations

Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response.

1995 • 271 citations

Cell-Type-Restricted Binding of the Transcription Factor NFAT to a Distal IL-4 Enhancer In Vivo

2000 • 270 citations

From Naive to Memory T Cells

1996 • 252 citations

Independent and Epigenetic Regulation of the Interleukin-4 Alleles in CD4 ⁺ T Cells

1998 • 250 citations

Interleukin 2, but Not Other Common γ Chain–Binding Cytokines, Can Reverse the Defect in Generation of Cd4 Effector T Cells from Naive T Cells of Aged Mice

1999 • 250 citations

Resting Memory CD8+ T Cells are Hyperreactive to Antigenic Challenge In Vitro

1996 • 241 citations

Following the Development of a CD4 T Cell Response In Vivo

1999 • 213 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

1997 • 204 citations

Instruction for Cytokine Expression in T Helper Lymphocytes in Relation to Proliferation and Cell Cycle Progression

1999 • 190 citations

Characterization of antigen-specific CD4+ effector T cells in vivo: immunization results in a transient population of MEL-14-, CD45RB- helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon gamma.

1991 • 179 citations

In Vivo Persistence of CD8 Polarized T Cell Subsets Producing Type 1 or Type 2 Cytokines

1998 • 179 citations

Naive, Effector, and Memory CD8 T Cells in Protection Against Pulmonary Influenza Virus Infection: Homing Properties Rather Than Initial Frequencies Are Crucial

1999 • 178 citations

Distinct Methylation of the Interferon γ (IFN-γ) and Interleukin 3 (IL-3) Genes in Newly Activated Primary CD8+ T Lymphocytes: Regional IFN-γ Promoter Demethylation and mRNA Expression Are Heritable in CD44highCD8+ T Cells

1998 • 171 citations

Two Distinct Stages in the Transition from Naive CD4 T Cells to Effectors, Early Antigen-Dependent and Late Cytokine-Driven Expansion and Differentiation

2000 • 161 citations

On the cellular basis of immunological T cell memory

1995 • 159 citations

Quantitative analysis of the influenza virus-specific CD4+ T cell memory in the absence of B cells and Ig.

1996 • 157 citations

Distinct Costimulatory Molecules Are Required for the Induction of Effector and Memory Cytotoxic T Lymphocytes

1997 • 137 citations

Immunological memory

1997 • 124 citations

Cutting edge: stable epigenetic inheritance of regional IFN-gamma promoter demethylation in CD44highCD8+ T lymphocytes.

1999 • 97 citations

Cutting Edge: Stable Epigenetic Inheritance of Regional IFN-γ Promoter Demethylation in CD44highCD8+ T Lymphocytes

1999 • 88 citations

High Antigen Density and IL-2 Are Required for Generation of CD4 Effectors Secreting Th1 Rather Than Th0 Cytokines

1998 • 74 citations

Helper T cell differentiation

1999 • 72 citations

Differential TCR signaling and the generation of memory T cells.

1998 • 71 citations

Antiviral CD4 and CD8 T–cell memory: differences in the size of the response and activation requirements

2000 • 64 citations

Cutting Edge Commentary: Differential TCR Signaling and the Generation of Memory T Cells

1998 • 60 citations

Effector CD4 T Cells Are Biochemically Distinct from the Memory Subset: Evidence for Long-Term Persistence of Effectors In Vivo

1999 • 60 citations

Withdrawal of Stimulation May Initiate the Transition of Effector to Memory CD4 Cells

2002 • 58 citations

Visualizing Memory Phenotype Development afterin VitroStimulation of CD4+T Cells

1998 • 44 citations