Suppressor of Cytokine Signaling 1 Regulates IL-15 Receptor Signaling in CD8+CD44high Memory T Lymphocytes

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

2000 • 1,596 citations

Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

2000 • 1,578 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

1998 • 1,293 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

Cytokine Signaling in 2002

2002 • 1,089 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).

1996 • 985 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Control of Homeostasis of CD8 ⁺ Memory T Cells by Opposing Cytokines

2000 • 847 citations

Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells

2002 • 783 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

1999 • 712 citations

Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells

2002 • 671 citations

Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation

2000 • 644 citations

Suppressors of cytokine signalling (SOCS) in the immune system

2002 • 633 citations

Negative Regulation of Cytokine Signaling Pathways

2000 • 607 citations

Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells

2002 • 588 citations

SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality

1999 • 531 citations

Homeostasis-Stimulated Proliferation Drives Naive T Cells to Differentiate Directly into Memory T Cells

2000 • 527 citations

Gigantism in mice lacking suppressor of cytokine signalling-2

2000 • 492 citations

Interferon‐γ confers resistance to experimental allergic encephalomyelitis

1996 • 478 citations

Cutting Edge: Naive T Cells Masquerading as Memory Cells

2000 • 476 citations

IL-15: A Pleiotropic Cytokine with Diverse Receptor/Signaling Pathways Whose Expression Is Controlled at Multiple Levels

1996 • 459 citations

Regulation of Antigen-Specific CD8 ⁺ T Cell Homeostasis by Perforin and Interferon-γ

2000 • 452 citations

RETRACTED: Uncoupling IL-2 Signals that Regulate T Cell Proliferation, Survival, and Fas-Mediated Activation-Induced Cell Death

1999 • 443 citations

Contrasting Roles of IL-2 and IL-15 in the Life and Death of Lymphocytes Implications for Immunotherapy

2001 • 441 citations

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1

1998 • 433 citations

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

1999 • 428 citations

Failure to Suppress the Expansion of the Activated Cd4 T Cell Population in Interferon γ–Deficient Mice Leads to Exacerbation of Experimental Autoimmune Encephalomyelitis

2000 • 424 citations

Interferon γ Is Required for Activation-induced Death of T Lymphocytes

2002 • 423 citations

IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice

2000 • 419 citations

The SOCS box: a tale of destruction and degradation

2002 • 409 citations

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.

1995 • 397 citations

SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

1999 • 372 citations

Cutting Edge: Increased Expression of Bcl-2 in Antigen-Specific Memory CD8+ T Cells

2000 • 355 citations

Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands

1999 • 341 citations

Interferon γ Eliminates Responding Cd4 T Cells during Mycobacterial Infection by Inducing Apoptosis of Activated Cd4 T Cells

2000 • 340 citations

The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2

2001 • 304 citations

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

2001 • 302 citations

Overexpression of Interleukin (IL)-7 Leads to IL-15–independent Generation of Memory Phenotype CD8+ T Cells

2002 • 291 citations

Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

1998 • 290 citations

Regulation of Jak2 through the Ubiquitin-Proteasome Pathway Involves Phosphorylation of Jak2 on Y1007 and Interaction with SOCS-1

2002 • 262 citations

Homeostasis of αβ TCR+ T cells

2000 • 251 citations

Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling

1998 • 246 citations

CYTOKINE RECEPTOR SIGNAL TRANSDUCTION AND THE CONTROL OF HEMATOPOIETIC CELL DEVELOPMENT

1996 • 207 citations

IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8⁺memory T cells

2002 • 199 citations

Socs-1 Inhibits TEL-JAK2-Mediated Transformation of Hematopoietic Cells through Inhibition of JAK2 Kinase Activity and Induction of Proteasome-Mediated Degradation

2001 • 175 citations

T Cell–Independent Interleukin 15rα Signals Are Required for Bystander Proliferation

2001 • 174 citations

Suppressor of Cytokine Signaling-1 Inhibits VAV Function through Protein Degradation

2000 • 168 citations

Homeostatic control of lymphocyte survival: potential origins and implications

2002 • 157 citations

Differential Roles of Interleukin 15 mRNA Isoforms Generated by Alternative Splicing in Immune Responses in Vivo

2000 • 153 citations

JAB/SOCS1/SSI-1 is an interleukin-2–induced inhibitor of IL-2 signaling

2001 • 140 citations

Targeted disruption of the interferon-γ receptor 2 gene results in severe immune defects in mice

1998 • 133 citations

Lymphocyte homeostasis

1997 • 133 citations

The tumor suppressor activity of SOCS-1

2002 • 133 citations

Different protein turnover of interleukin‐6‐type cytokine signalling components

1999 • 123 citations

Contrasting Roles of IL-2 and IL-15 in the Life and Death of Lymphocytes

2001 • 114 citations

Survival of Naive CD4 T Cells: Roles of Restricting Versus Selecting MHC Class II and Cytokine Milieu

1999 • 105 citations

Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)

2002 • 102 citations

Intracellular staining for TNF and IFN-γ detects different frequencies of antigen-specific CD8+ T cells

2000 • 99 citations

Reduced Expression of Bcl-2 in CD8+ T Cells Deficient in the IL-15 Receptor α-Chain

2002 • 95 citations

Defective Thymocyte Development and Perturbed Homeostasis of T cells in STAT-Induced STAT Inhibitor-1/Suppressors of Cytokine Signaling-1 Transgenic Mice

2000 • 84 citations

The Growth of the Very Large CD8+ T Cell Clones in Older Mice Is Controlled by Cytokines

2001 • 81 citations

Apoptotic Regulation of T Cells and Absence of Immune Deficiency in Virus-Infected Gamma Interferon Receptor Knockout Mice

1998 • 77 citations

Regulation of SOCS-1 Expression by Translational Repression

2000 • 70 citations

Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor–induced proliferation but not differentiation of immature thymocytes

2001 • 47 citations

Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways

2002 • 39 citations

Stability of Naive and Memory Phenotypes on Resting CD4 T Cells In Vivo

1999 • 37 citations

Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways

2002 • 25 citations

Flow cytometric analysis of cytokine receptor signal transduction

2003 • 19 citations

Constitutive Expression of a Chimeric Receptor That Delivers IL-2/IL-15 Signals Allows Antigen-Independent Proliferation of CD8+CD44high But Not Other T Cells

2000 • 17 citations