Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

2000 • 2,358 citations

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

2001 • 2,274 citations

A multidrug resistance transporter from human MCF-7 breast cancer cells

1998 • 2,273 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER

1999 • 2,049 citations

Pharmacogenomics — Drug Disposition, Drug Targets, and Side Effects

2003 • 1,750 citations

A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins

2000 • 1,723 citations

The Human ATP-Binding Cassette (ABC) Transporter Superfamily

2001 • 1,705 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.

2001 • 1,116 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Identification of functionally variant MDR1 alleles among European Americans and African Americans

2001 • 1,000 citations

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1991 • 962 citations

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1997 • 934 citations

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

1999 • 911 citations

Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance

2004 • 900 citations

Role of P-Glycoprotein in Pharmacokinetics

2003 • 897 citations

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1997 • 871 citations

Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes.

1999 • 810 citations

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria

2002 • 807 citations

A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance.

1998 • 798 citations

The Role of ABC Transporters in Clinical Practice

2003 • 782 citations

Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects

2001 • 757 citations

From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance

2001 • 686 citations

Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.

2002 • 682 citations

Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study

2002 • 670 citations

Studies With RP 56976 (Taxotere): A Semisynthetic Analogue of Taxol

1991 • 668 citations

Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1

2003 • 653 citations

The Stem Cell Marker Bcrp/ABCG2 Enhances Hypoxic Cell Survival through Interactions with Heme

2004 • 648 citations

Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus

2003 • 646 citations

Role of Breast Cancer Resistance Protein in the Bioavailability and Fetal Penetration of Topotecan

2000 • 640 citations

Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study.

2004 • 631 citations

St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

2000 • 587 citations

Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene.

2001 • 538 citations

Choroid plexus epithelial expression of MDR 1 P glycoprotein and multidrug resistance-associated protein contribute to the blood–cerebrospinal-fluid drug-permeability barrier

1999 • 529 citations

Bcrp1gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cellsin vivo

2002 • 506 citations

Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein.

2000 • 494 citations

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.

1988 • 489 citations

Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line.

1999 • 475 citations

The physiological function of drug-transporting P-glycoproteins

1997 • 457 citations

Increased Oral Bioavailability of Topotecan in Combination With the Breast Cancer Resistance Protein and P-Glycoprotein Inhibitor GF120918

2002 • 452 citations

The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients

2004 • 434 citations

C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance.

2002 • 432 citations

Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.

2001 • 427 citations

Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene

2003 • 420 citations

MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity

2001 • 418 citations

Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump

2004 • 415 citations

The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity

2001 • 377 citations

The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells

2001 • 377 citations

Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720

2002 • 374 citations

In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833.

1991 • 364 citations

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

2000 • 358 citations

The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin.

1999 • 353 citations

Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure

1999 • 352 citations

Atypical Multidrug Resistance: Breast Cancer Resistance Protein Messenger RNA Expression in Mitoxantrone-Selected Cell Lines

1999 • 351 citations

Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes [see comments]

1992 • 347 citations

Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity

2003 • 347 citations

Overview: ABC transporters and human disease.

2001 • 342 citations

Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells.

2001 • 338 citations

Pheophorbide a Is a Specific Probe for ABCG2 Function and Inhibition

2004 • 332 citations

Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979.

1996 • 329 citations

Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 in Vitro

2004 • 324 citations

Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis

2003 • 323 citations

MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects.

2001 • 319 citations

Tacrolimus pharmacogenetics: polymorphisms associated with expression of cytochrome p4503A5 and p-glycoprotein correlate with dose requirement

2002 • 318 citations

Single nucleotide polymorphisms result in impaired membrane localization and reduced atpase activity in multidrug transporter ABCG2

2003 • 309 citations

Genetic Polymorphisms of the HumanMDR1Drug Transporter

2003 • 308 citations

Modulation of steady‐state kinetics of digoxin by haplotypes of the P‐glycoprotein MDR1 gene

2002 • 307 citations

Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport.

2003 • 303 citations

Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C.

1998 • 301 citations

RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response.

2003 • 297 citations

Single nucleotide polymorphisms and outcome in docetaxel–cisplatin-treated advanced non-small-cell lung cancer

2004 • 293 citations

Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR

1999 • 291 citations

Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes [see comments]

1992 • 290 citations

Association of the Multidrug Resistance-1 Gene Single-Nucleotide Polymorphisms with the Tacrolimus Dose Requirements in Renal Transplant Recipients

2003 • 281 citations

Distinct haplotype profiles and strong linkage disequilibrium at the MDR1 multidrug transporter gene locus in three ethnic Asian populations

2002 • 281 citations

The Effect of Rifampin Treatment on Intestinal Expression of Human MRP Transporters

2000 • 278 citations

Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine

2003 • 274 citations

Explaining Interindividual Variability of Docetaxel Pharmacokinetics and Pharmacodynamics in Asians Through Phenotyping and Genotyping Strategies

2002 • 269 citations

Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P‐glycoprotein

2002 • 268 citations

Characterization of Oligomeric Human Half-ABC Transporter ATP-binding Cassette G2

2004 • 266 citations

Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects

2002 • 266 citations

FUNCTIONAL ASSESSMENT OFABCG2(BCRP) GENE POLYMORPHISMS TO PROTEIN EXPRESSION IN HUMAN PLACENTA

2004 • 265 citations

Tacrolimus Dosing in Pediatric Heart Transplant Patients is Related to CYP3A5 and MDR1 Gene Polymorphisms

2003 • 265 citations

No Influence of the MDR-1 C3435T Polymorphism or a CYP3A4 Promoter Polymorphism (CYP3A4-V Allele) on Dose-adjusted Cyclosporin A Trough Concentrations or Rejection Incidence in Stable Renal Transplant Recipients

2001 • 261 citations

The molecular interaction of the high affinity reversal agent XR9576 with P‐glycoprotein

1999 • 258 citations

Functional Analysis of SNPs Variants of BCRP/ABCG2

2004 • 257 citations

Irinotecan pathway genotype analysis to predict pharmacokinetics.

2003 • 254 citations

MDR1 gene polymorphisms and disposition of the P‐glycoprotein substrate fexofenadine

2002 • 250 citations

Association of the P-Glycoprotein Transporter MDR1 C3435T Polymorphism with the Susceptibility to Renal Epithelial Tumors

2002 • 250 citations

Influence of CYP3A5 and MDR1 (ABCB1) Polymorphisms on the Pharmacokinetics of Tacrolimus in Renal Transplant Recipients

2004 • 248 citations

Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients

2003 • 248 citations

The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans

2002 • 247 citations

MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patients.

2002 • 247 citations

Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype*1

2004 • 241 citations

A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2)

2001 • 240 citations

MDR1 Ala893 Polymorphism Is Associated with Inflammatory Bowel Disease

2003 • 240 citations

Effect of grapefruit juice on digoxin pharmacokinetics in humans.

2001 • 235 citations

The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

2003 • 234 citations

Breast Cancer Resistance Protein Directly Confers SN-38 Resistance of Lung Cancer Cells

2001 • 233 citations

Breast Cancer Resistance Protein Exports Sulfated Estrogens but Not Free Estrogens

2003 • 233 citations

A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels

1998 • 232 citations

Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene

2001 • 223 citations

The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux.

2001 • 222 citations

HIV Protease Inhibitors Are Inhibitors but Not Substrates of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)

2004 • 218 citations

Natural variation in human membrane transporter genes reveals evolutionary and functional constraints

2003 • 217 citations

Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter.

2003 • 216 citations

Identification of a Novel Estrogen Response Element in the Breast Cancer Resistance Protein ( ABCG2 ) Gene

2004 • 216 citations

Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue.

1992 • 212 citations

Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1

2002 • 209 citations

ABCG2 Pharmacogenetics

2004 • 205 citations

A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression

2002 • 204 citations

Coadministration of oral cyclosporin A enables oral therapy with paclitaxel.

1999 • 202 citations

The effects of the human MDR1 genotype on the expression of duodenal P‐glycoprotein and disposition of the probe drug talinolol

2002 • 201 citations

Daunorubicin-resistant Chinese hamster ovary cells expressing multidrug resistance and a cell-surface P-glycoprotein.

1983 • 201 citations

Coadministration of Cyclosporine Strongly Enhances the Oral Bioavailability of Docetaxel

2001 • 200 citations

Dosing strategies for anticancer drugs: the good, the bad and body-surface area

2002 • 197 citations

ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2

2001 • 197 citations

Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance.

2000 • 196 citations

Multidrug resistance and pharmacological protection mediated by the breast cancer resistance protein (BCRP/ABCG2).

2002 • 196 citations

Functional C3435T polymorphism of MDR1 gene: an impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemia

2004 • 196 citations

C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation

2002 • 194 citations

Polymorphism in the P-glycoprotein drug transporter MDR1 gene: a possible link between environmental and genetic factors in Parkinson's disease.

2003 • 194 citations

Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors

2003 • 193 citations

CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantation

2004 • 187 citations

Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis

2004 • 180 citations

Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene

2002 • 180 citations

Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic polymorphisms in the and genes

2004 • 172 citations

Digoxin pharmacokinetics and MDR1 genetic polymorphisms

2003 • 169 citations

VX-710 (Biricodar) Increases Drug Retention and Enhances Chemosensitivity in Resistant Cells Overexpressing P-Glycoprotein, Multidrug Resistance Protein, and Breast Cancer Resistance Protein

2004 • 165 citations

The Effect of CYP3A5 and MDR1 Polymorphic Expression on Cyclosporine Oral Disposition in Renal Transplant Patients

2003 • 162 citations

Multidrug Resistance and Cancer: The Role of the Human ABC Transporter ABCG2

2002 • 161 citations

Oral Delivery of Taxanes

2001 • 158 citations

Sterol Transport by the Human Breast Cancer Resistance Protein (ABCG2) Expressed in Lactococcus lactis

2003 • 158 citations

Modulation of P-glycoprotein function in human lymphocytes and Caco-2 cell monolayers by HIV-1 protease inhibitors

1999 • 157 citations

Genetic Polymorphism in MDR-1: A Tool for Examining Allelic Expression in Normal Cells, Unselected and Drug-Selected Cell Lines, and Human Tumors

1998 • 157 citations

MDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white males

2002 • 153 citations

Functional Characterization of Coding Polymorphisms in the HumanMDR1 Gene Using a Vaccinia Virus Expression System

2002 • 152 citations

Tacrolimus Dosing in Adult Lung Transplant Patients Is Related to Cytochrome P4503A5 Gene Polymorphism

2004 • 148 citations

Modulation of oral bioavailability of anticancer drugs: from mouse to man

2000 • 147 citations

ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation

2003 • 141 citations

A mutation hot spot in the Bcrp1 (Abcg2) multidrug transporter in mouse cell lines selected for Doxorubicin resistance.

2002 • 140 citations

Variable expression of P-glycoprotein in the human placenta and its association with mutations of the multidrug resistance 1 gene (MDR1, ABCB1)

2004 • 139 citations

Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan

2003 • 138 citations

Polymorphism in the P-glycoprotein drug transporter MDR1 gene

2003 • 138 citations

Polymorphisms in the ABC drug transporter gene MDR1

2001 • 136 citations

Low systemic exposure of oral docetaxel in mice resulting from extensive first-pass metabolism is boosted by ritonavir.

2002 • 134 citations

Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia

2003 • 133 citations

The predictive value of MDR1, CYP2C9, and CYP2C19 polymorphisms for phenytoin plasma levels

2001 • 132 citations

Effects of Polymorphisms of MDR1, MRP1, and MRP2 Genes on Their mRNA Expression Levels in Duodenal Enterocytes of Healthy Japanese Subjects.

2002 • 131 citations

Cellular and biochemical characterization of VX-710 as a chemosensitizer

1997 • 131 citations

THE PHARMACOLOGICAL ROLE OF P-GLYCOPROTEIN IN THE INTESTINAL EPITHELIUM

1998 • 130 citations

Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677: functional relevance to pharmacokinetics of digoxin.

2002 • 129 citations

The role of half-transporters in multidrug resistance.

2001 • 128 citations

Polymorphism C3435T of the MDR-1 gene predicts response to preoperative chemotherapy in locally advanced breast cancer

2003 • 123 citations

Prediction of Irinotecan Pharmacokinetics by Use of Cytochrome P450 3A4 Phenotyping Probes

2004 • 120 citations

Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8

2002 • 119 citations

Modulation of Irinotecan Metabolism by Ketoconazole

2002 • 119 citations

A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport

2003 • 119 citations

Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy.

2003 • 118 citations

Single-Nucleotide Polymorphism (SNP) Analysis in the ABC Half-Transporter ABCG2 (MXR/BCRP/ABCP1)

2002 • 116 citations

Differential amplification and disproportionate expression of five genes in three multidrug-resistant Chinese hamster lung cell lines.

1986 • 113 citations

Transport of Topoisomerase I Inhibitors by the Breast Cancer Resistance Protein: Potential Clinical Implications

2000 • 113 citations

ABC transporters and inhibitors: new targets, new agents.

2002 • 112 citations

A variant 2677A allele of the gene affects fexofenadine disposition

2004 • 112 citations

Improvement of Oral Drug Treatment by Temporary Inhibition of Drug Transporters and/or Cytochrome P450 in the Gastrointestinal Tract and Liver: An Overview

2002 • 109 citations

Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists.

2003 • 109 citations

Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers

2003 • 104 citations

The MDR1 polymorphisms at exons 21 and 26 predict steroid weaning in pediatric heart transplant patients

2002 • 103 citations

The orally administered P-glycoprotein inhibitor R101933 does not alter the plasma pharmacokinetics of docetaxel.

2000 • 100 citations

Pharmacogenetics of the human drug-transporter gene MDR1: impact of polymorphisms on pharmacotherapy

2001 • 98 citations

Characterization of the multidrug resistance protein expressed in cell clones stably transfected with the mouse mdr1 cDNA.

1989 • 97 citations

Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure.

2001 • 97 citations

Enhanced exposure of phosphatidylserine in human gastric carcinoma cells overexpressing the half-size ABC transporter BCRP (ABCG2)

2003 • 95 citations

Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response

2003 • 95 citations

Genetic variation in the ATP-binding Cassette Transporter gene ABCG2 (BCRP) in a Swedish population

2003 • 95 citations

Clinical pharmacokinetics of doxorubicin in combination with GF120918, a potent inhibitor of MDR1 P-glycoprotein

1999 • 91 citations

MDR1 gene–related clonal selection and P-glycoprotein function and expression in relapsed or refractory acute myeloid leukemia

2001 • 90 citations

ABCG2 Mediates Differential Resistance to SN-38 (7-Ethyl-10-hydroxycamptothecin) and Homocamptothecins

2004 • 89 citations

Estrone and 17β‐Estradiol Reverse Breast Cancer Resistance Protein‐mediated Multidrug Resistance

2002 • 88 citations

Influence of functional polymorphisms of the gene on vincristine pharmacokinetics in childhood acute lymphoblastic leukemia

2004 • 88 citations

Pharmacogenomics ofMDR1/ABCB1Gene: the Influence on Risk and Clinical Outcome of Haematological Malignancies

2004 • 85 citations

Association between ABCB1 (multidrug resistance transporter) genotype and post-liver transplantation renal dysfunction in patients receiving calcineurin inhibitors

2003 • 85 citations

Role of intestinal P-glycoprotein in the plasma and fecal disposition of docetaxel in humans.

2000 • 84 citations

Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population

2002 • 82 citations

EXPRESSION AND FUNCTION OF ABCB1 AND ABCG2 IN HUMAN PLACENTAL TISSUE

2005 • 81 citations

Modulation of multidrug resistance P-glycoprotein 1 (ABCB1) expression in human heart by hereditary polymorphisms

2004 • 81 citations

An Essential Role of Th1 Responses and Interferon-gamma in Infection-Mediated Suppression of Neoplastic Growth

2003 • 80 citations

Haplotype-Oriented Genetic Analysis and Functional Assessment of Promoter Variants in theMDR1(ABCB1) Gene

2004 • 79 citations

C3435T Mutation in Exon 26 of the Human MDR1 Gene and Cyclosporine Pharmacokinetics in Healthy Subjects

2002 • 79 citations

Multidrug Resistance in Cancer Chemotherapy and Xenobiotic Protection Mediated by the Half ATP-Binding Cassette Transporter ABCG2

2004 • 79 citations

MDR-1 C3435T Polymorphism Influences Cyclosporine A Dose Requirement in Liver-Transplant Recipients

2004 • 77 citations

Biliary transport of irinotecan and metabolites in normal and P-glycoprotein-deficient mice

2002 • 75 citations

MDR1 haplotypes derived from exons 21 and 26 do not affect the steady‐state pharmacokinetics of tacrolimus in renal transplant patients

2004 • 75 citations

The importance of drug-transporting P-glycoproteins in toxicology

2001 • 74 citations

Complementary and alternative medicine: Opportunities and challenges for cancer management and research

2002 • 73 citations

Evaluation of Accelerator Mass Spectrometry in a Human Mass Balance and Pharmacokinetic Study–Experience with¹⁴C-labeled (R)-6-[Amino(4- chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1- methyl-2(1H)-quinolinone (R115777), a Farnesyl Transferase Inhibitor

2002 • 73 citations

Differential effects of the breast cancer resistance protein on the cellular accumulation and cytotoxicity of 9-aminocamptothecin and 9-nitrocamptothecin.

2003 • 73 citations

MDR1 polymorphisms G2677T in exon 21 and C3435T in exon 26 fail to affect rhodamine 123 efflux in peripheral blood lymphocytes

2003 • 69 citations

Expression of Pregnane-X-Receptor Transcript in Peripheral Blood Mononuclear Cells and Correlation with Mdr1 Mrna

2004 • 65 citations

Effects of Grapefruit Juice on Intestinal P‐glycoprotein: Evaluation Using Digoxin in Humans

2003 • 65 citations

Growth inhibitory effect of a new camptothecin analog, DX-8951f, on various drug-resistant sublines including BCRP-mediated camptothecin derivative-resistant variants derived from the human lung cancer cell line PC-6

2000 • 63 citations

MDR1Haplotypes Do Not Affect the Steady-State Pharmacokinetics of Cyclosporine in Renal Transplant Patients

2003 • 63 citations

Dexamethasone as a probe for docetaxel clearance

2004 • 62 citations

MDR1 genotype-related duodenal absorption rate of digoxin in healthy Japanese subjects.

2003 • 60 citations

CPT-11 sensitivity in relation to the expression of P170-glycoprotein and multidrug resistance-associated protein

1998 • 59 citations

Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.

1996 • 58 citations

Eight Novel Single Nucleotide Polymorphisms in ABCG2/BCRP in Japanese Cancer Patients Administered Irinotacan

2003 • 57 citations

MDR1 Gene Polymorphisms and Phase 1 Viral Decay During HIV-1 Infection

2003 • 57 citations

Hematopoietic cells from mice that are deficient in both Bcrp1/Abcg2 and Mdr1a/1b develop normally but are sensitized to mitoxantrone

2003 • 56 citations

Resistance to mitoxantrone in multidrug-resistant MCF7 breast cancer cells: evaluation of mitoxantrone transport and the role of multidrug resistance protein family proteins.

2001 • 56 citations

Analysis of MDR1 haplotypes in Parkinson's disease in a white population

2004 • 54 citations

No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects

2003 • 54 citations

THE PREGNANE X RECEPTOR BINDS TO RESPONSE ELEMENTS IN A GENOMIC CONTEXT-DEPENDENT MANNER, AND PXR ACTIVATOR RIFAMPICIN SELECTIVELY ALTERS THE BINDING AMONG TARGET GENES

2004 • 54 citations

Quantitative determination of MDR1 mRNA expression in peripheral blood lymphocytes: a possible role of genetic polymorphisms in the MDR1 gene

2003 • 54 citations

Genetic polymorphism at the 5' regulatory region of multidrug resistance 1 (MDR1) and its association with interindividual variation of expression level in the colon.

2003 • 51 citations

Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivatives ortataxel (IDN-5109, BAY 59-8862) and tRA96023

2004 • 49 citations

Phenomenology and Scientific Progress

2002 • 47 citations

Acquired resistance of human T cells to sulfasalazine: stability of the resistant phenotype and sensitivity to non-related DMARDs

2004 • 43 citations

Alternate Overexpression of Two Phosphoglycoprotein Genes Is Associated with Changes in Multidrug Resistance in a J774.2 Cell Line

1989 • 42 citations

Does P-glycoprotein play a role in anticancer drug pharmacokinetics?

2000 • 40 citations

Reversal of P-glycoprotein mediated multidrug resistance by a newly synthesized 1,4-benzothiazipine derivative, JTV-519

2002 • 36 citations

Novobiocin sensitizes BCRP/MXR/ABCP overexpressing topotecan-resistant human breast carcinoma cells to topotecan and mitoxantrone.

2003 • 34 citations

Genetic characterization of the multidrug-resistant phenotype of VM-26-resistant human leukemic cells.

1989 • 31 citations

CYP3A activity measured by the midazolam test is not related to 3435 C>T polymorphism in the multiple drug resistance transporter gene

2004 • 29 citations

Reciprocal cross-resistance in human rhabdomyosarcomas selected in vivo for primary resistance to vincristine and L-phenylalanine mustard.

1987 • 28 citations

Common single nucleotide polymorphisms of the MDR1 gene have no influence on its mRNA expression level of normal kidney cortex and renal cell carcinoma in Japanese nephrectomized patients

2003 • 27 citations

The HUGO Mutation Database Initiative

2002 • 24 citations

MDR1Genetic Polymorphism Does Not Modify either Cell Permissiveness to HIV‐1 or Disease Progression before Treatment

2004 • 23 citations

Pharmacogenetics of tipifarnib (R115777) transport and metabolism in cancer patients

2004 • 20 citations

A multidrug efflux phenotype mutant of Streptococcus pyogenes

2003 • 16 citations

<i>MDR1</i> Genotypes Related to Pharmacokinetics and MDR1 Expression

2003 • 8 citations

The effect of induction conditions and MDR1 genotypes on dicloxacillin pharmacokinetics

2003 • 8 citations

The Q141K single-nucleotide polymorphism impacts the transporter activity of ABCG2.

2004 • 4 citations

Modulation of multidrug resistance with dexniguldipine hydrochloride (B8509-035) in the CC531 rat colon carcinoma model

1996 • 4 citations

Effect of ABCG2 genotype and mRNA expression on the bioavailability of topotecan

2004 • 1 citations

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