Alternate Overexpression of Two Phosphoglycoprotein Genes Is Associated with Changes in Multidrug Resistance in a J774.2 Cell Line

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

1986 • 791 citations

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1974 • 695 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

Mechanism of multidrug resistance

1988 • 630 citations

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1988 • 430 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

1988 • 340 citations

Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers.

1987 • 333 citations

Multidrug Resistance1

1988 • 321 citations

Role of the Glutathione Redox Cycle in Acquired and de Novo Multidrug Resistance

1988 • 301 citations

Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells.

1986 • 290 citations

Progesterone Interacts with P-Glycoprotein in Multidrug-resistant Cells and in the Endometrium of Gravid Uterus

1989 • 290 citations

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells

1989 • 241 citations

ATP‐binding properties of P glycoprotein from multidrug‐resistant KB cells

1987 • 207 citations

Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil.

1988 • 205 citations

A phosphoglycoprotein associated with taxol resistance in J774.2 cells.

1985 • 158 citations

Identification of a calmodulin-binding protein that co-purifies with the regulatory subunit of brain protein kinase II.

1984 • 130 citations

Biosynthesis of heterogeneous forms of multidrug resistance-associated glycoproteins.

1987 • 110 citations

Retroviral transfer of a murine cDNA for multidrug resistance confers pleiotropic drug resistance to cells without prior drug selection.

1988 • 107 citations

Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines.

1988 • 99 citations

Azidopine photoaffinity labeling of multidrug resistance-associated glycoproteins

1988 • 86 citations

Energy-dependent reduced drug binding as a mechanism of Vinca alkaloid resistance in human leukemic lymphoblasts.

1983 • 82 citations

Electrophoretic Analysis of P-glycoproteins Produced by Mouse J774.2 and Chinese Hamster Ovary Multidrug-Resistant Cells

1988 • 56 citations

Use of antibodies to probe membrane glycoproteins associated with drug-resistant J774.2 cells

1987 • 31 citations