Multidrug resistance in cancer: role of ATP–dependent transporters

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

A multidrug resistance transporter from human MCF-7 breast cancer cells

1998 • 2,273 citations

Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy

2001 • 2,069 citations

BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER

1999 • 2,049 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins

2000 • 1,723 citations

The Human ATP-Binding Cassette (ABC) Transporter Superfamily

2001 • 1,705 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 • 1,268 citations

Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.

2001 • 1,116 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1990 • 1,063 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

1998 • 980 citations

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1991 • 962 citations

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1997 • 934 citations

The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver

1998 • 933 citations

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

1999 • 911 citations

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1997 • 871 citations

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

2001 • 830 citations

Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene

1996 • 827 citations

Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes.

1999 • 810 citations

A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance.

1998 • 798 citations

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

1999 • 796 citations

Delivery of molecular and cellular medicine to solid tumors

2012 • 766 citations

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

Mutations in the MDR 3 gene cause progressive familial intrahepatic cholestasis

1998 • 718 citations

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*

1997 • 675 citations

Role of Breast Cancer Resistance Protein in the Bioavailability and Fetal Penetration of Topotecan

2000 • 640 citations

MRP3, an organic anion transporter able to transport anti-cancer drugs

1999 • 639 citations

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1994 • 621 citations

Phosphatidylcholine translocase: A physiological role for the mdr2 gene

1994 • 600 citations

Frequency and Clinical Significance of the Expression of the Multidrug Resistance Proteins MDR1/P-Glycoprotein, MRP1, and LRP in Acute Myeloid Leukemia. A Southwest Oncology Group Study

1999 • 596 citations

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

1999 • 579 citations

Role of tumor–host interactions in interstitial diffusion of macromolecules: Cranial vs. subcutaneous tumors

2001 • 576 citations

Mutations in ABCC6 cause pseudoxanthoma elasticum

2000 • 575 citations

Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.

1996 • 569 citations

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

1997 • 551 citations

Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum

2000 • 531 citations

Choroid plexus epithelial expression of MDR 1 P glycoprotein and multidrug resistance-associated protein contribute to the blood–cerebrospinal-fluid drug-permeability barrier

1999 • 529 citations

In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.

1993 • 526 citations

Delivery of molecular and cellular medicine to solid tumors1PII of original article: S0169-409X(97)00027-6. The article was originally published in Advanced Drug Delivery Reviews 26 (1997) 71–90.1

2001 • 509 citations

Selection of Drug-Resistant Bone Marrow Cells in Vivo After Retroviral Transfer of Human MDR 1

1992 • 500 citations

Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

1996 • 487 citations

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

2000 • 473 citations

Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood.

1990 • 462 citations

The Multidrug Resistance Protein 5 Functions as an ATP-dependent Export Pump for Cyclic Nucleotides

2000 • 438 citations

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

1997 • 432 citations

Multidrug Resistance in Breast Cancer: a Meta-analysis of MDR1/gp170 Expression and Its Possible Functional Significance

1997 • 428 citations

Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.

2001 • 427 citations

Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study

2001 • 421 citations

Expression of P-Glycoprotein in High-Grade Osteosarcomas in Relation to Clinical Outcome

1995 • 401 citations

Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations.

1996 • 398 citations

Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione.

1998 • 392 citations

Pseudoxanthoma elasticum: Mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter

2000 • 390 citations

Transport of Cyclic Nucleotides and Estradiol 17-β-d-Glucuronide by Multidrug Resistance Protein 4

2001 • 389 citations

Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome

1996 • 372 citations

Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells.

1999 • 362 citations

Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen.

1994 • 334 citations

Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979.

1996 • 329 citations

Expression of members of the multidrug resistance protein family in human term placenta

2000 • 321 citations

Modulation of multidrug-resistant multiple myeloma by cyclosporin

1992 • 317 citations

Targeted inactivation of sister of P-glycoprotein gene ( spgp ) in mice results in nonprogressive but persistent intrahepatic cholestasis

2001 • 312 citations

Ceramide glycosylation potentiates cellular multidrug resistance

2001 • 303 citations

ABC transporters in lipid transport

2000 • 300 citations

Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance.

1992 • 298 citations

Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR

1997 • 294 citations

Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR

1999 • 291 citations

Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia.

1993 • 284 citations

Levels of multidrug resistance (MDR1) P-glycoprotein expression by human breast cancer correlate with in vitro resistance to taxol and doxorubicin.

1998 • 282 citations

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.

1997 • 272 citations

Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells.

1996 • 262 citations

Human P-Glycoprotein Exhibits Reduced Affinity for Substrates during a Catalytic Transition State

1998 • 247 citations

Expression of breast cancer resistance protein in blast cells from patients with acute leukemia

2000 • 233 citations

Rapid activation of MDR1 gene expression in human metastatic sarcoma after in vivo exposure to doxorubicin.

1999 • 230 citations

Drug Resistance-Associated Marker Lrp for Prediction of Response to Chemotherapy and Prognoses in Advanced Ovarian Carcinoma

1995 • 225 citations

Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance.

1998 • 221 citations

Clinical trials of p-glycoprotein reversal in solid tumours

1996 • 210 citations

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

2000 • 210 citations

Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies.

2000 • 206 citations

The role of P‐glycoprotein in blood‐brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (−/−) and mdr1a (+/+) mice

1999 • 198 citations

Transduction of Murine Bone Marrow Cells With an MDR1 Vector Enables Ex Vivo Stem Cell Expansion, but These Expanded Grafts Cause a Myeloproliferative Syndrome in Transplanted Mice

1998 • 197 citations

Phase I trial of doxorubicin with cyclosporine as a modulator of multidrug resistance.

1994 • 186 citations

Simultaneous Activity of MRP1 and Pgp Is Correlated With In Vitro Resistance to Daunorubicin and With In Vivo Resistance in Adult Acute Myeloid Leukemia

1999 • 181 citations

Expression of breast cancer resistance protein in blast cells from patients with acute leukemia

2000 • 175 citations

Expression of the multidrug resistance-associated protein (MRP) gene in human cancers.

1995 • 174 citations

Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer

2000 • 171 citations

Expression of multidrug resistance protein-related genes in lung cancer: correlation with drug response.

1999 • 168 citations

In vivo detection of multidrug-resistant (MDR1) phenotype by technetium-99m sestamibi scan in untreated breast cancer patients

1997 • 167 citations

Clinical Studies with Modulators of Multidrug Resistance

1995 • 163 citations

Treatment of Refractory and Relapsed Acute Myelogenous Leukemia With Combination Chemotherapy Plus the Multidrug Resistance Modulator PSC 833 (Valspodar)

1999 • 152 citations

The prognostic significance of expression of the multidrug resistance-associated protein (MRP) in primary breast cancer

1997 • 151 citations

Engraftment of MDR1 and NeoR Gene-Transduced Hematopoietic Cells After Breast Cancer Chemotherapy

1999 • 146 citations

The effect of verapamil on the pharmacokinetics of adriamycin

1986 • 146 citations

Phase I and pharmacokinetic study of paclitaxel in combination with biricodar, a novel agent that reverses multidrug resistance conferred by overexpression of both MDR1 and MRP.

1998 • 146 citations

Taxol resistance mediated by transfection of the liver-specific sister gene of P-glycoprotein.

1998 • 144 citations

MOAT-E (ARA) is a full-length MRP/cMOAT subfamily transporter expressed in kidney and liver

1999 • 143 citations

99mTc-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein

1998 • 141 citations

Mutations of the gene encoding the transmembrane transporter protein ABC-C6 cause pseudoxanthoma elasticum

2000 • 140 citations

Pharmacological considerations in the modulation of multidrug resistance

1996 • 139 citations

P-glycoprotein Expression: Critical Determinant in the Response to Osteosarcoma Chemotherapy

1997 • 138 citations

Increased Bioavailability of the Food-Derived Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-Deficient Rats

2001 • 130 citations

Differential inhibition by cyclosporins of primary‐active ATP‐dependent transporters in the hepatocyte canalicular membrane

1993 • 128 citations

The prognostic significance of membrane transport-associated multidrug resistance (MDR) proteins in leukemia

2000 • 124 citations

Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein.

2000 • 124 citations

Treatment of Refractory and Relapsed Acute Myelogenous Leukemia With Combination Chemotherapy Plus the Multidrug Resistance Modulator PSC 833 (Valspodar)

1999 • 122 citations

Modulation of the multidrug resistance P-glycoprotein: detection with technetium-99m-sestamibi in vivo.

1997 • 121 citations

P‐glycoprotein, lung resistance‐related protein and multidrug resistance associated protein in de novo acute non‐lymphocytic leukaemias: biological and clinical implications

1999 • 119 citations

Combination of quinine as a potential reversing agent with mitoxantrone and cytarabine for the treatment of acute leukemias: a randomized multicenter study

1996 • 119 citations

P-Glycoprotein Shows Strong Catalytic Cooperativity between the Two Nucleotide Sites

1998 • 107 citations

Phase I and Pharmacokinetic Study of the Novel MDR1 and MRP1 Inhibitor Biricodar Administered Alone and in Combination With Doxorubicin

2001 • 107 citations

Resistance of tumor cells to chemo- and radiotherapy modulated by the three-dimensional architecture of solid tumors and spheroids

2001 • 106 citations

P-glycoprotein and multidrug resistance protein activities in relation to treatment outcome in acute myeloid leukemia.

2000 • 106 citations

Detection of in vivo P-glycoprotein inhibition by PSC 833 using Tc-99m sestamibi.

1997 • 104 citations

Expression of the multidrug resistance-associated protein (MRP) in acute and chronic leukemias.

1994 • 104 citations

Ex vivo expansion and selection of human CD34+ peripheral blood progenitor cells after introduction of a mutated dihydrofolate reductase cDNA via retroviral gene transfer

1995 • 103 citations

Cross-resistance to methotrexate and metals in human cisplatin-resistant cell lines results from a pleiotropic defect in accumulation of these compounds associated with reduced plasma membrane binding proteins.

1998 • 102 citations

Immunohistochemical detection of multidrug resistance protein in human lung cancer and normal lung.

1998 • 98 citations

Decreased accumulation of [14c]carboplatin in human cisplatin-resistant cells results from reduced energy-dependent uptake

2000 • 98 citations

P-Glycoprotein Inhibitor Valspodar (PSC 833) Increases the Intracellular Concentrations of Daunorubicin In Vivo in Patients With P-Glycoprotein–Positive Acute Myeloid Leukemia

2000 • 97 citations

Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure.

2001 • 97 citations

P-glycoprotein expression is a marker for chemotherapy resistance and prognosis in advanced ovarian cancer.

2000 • 95 citations

Phase I study of mitoxantrone plus etoposide with multidrug blockade by SDZ PSC-833 in relapsed or refractory acute myelogenous leukemia.

1997 • 95 citations

MRP and MDR1 gene expression in primary breast carcinomas.

1996 • 94 citations

Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy.

1995 • 92 citations

Cloning and characterization of human adenosine 5'-triphosphate-binding cassette, sub-family A, transporter 2 (ABCA2).

2001 • 92 citations

MDR1 Gene Expression and Outcome in Osteosarcoma: A Prospective, Multicenter Study

2000 • 92 citations

Phase II Study of Paclitaxel and Valspodar (PSC 833) in Refractory Ovarian Carcinoma: A Gynecologic Oncology Group Study

2001 • 91 citations

Clinical pharmacokinetics of doxorubicin in combination with GF120918, a potent inhibitor of MDR1 P-glycoprotein

1999 • 91 citations

Phase I Study of Infusional Paclitaxel in Combination With the P-Glycoprotein Antagonist PSC 833

2001 • 89 citations

Parallel Phase I Studies of Daunorubicin Given With Cytarabine and Etoposide With or Without the Multidrug Resistance Modulator PSC-833 in Previously Untreated Patients 60 Years of Age or Older With Acute Myeloid Leukemia: Results of Cancer and Leukemia Group B Study 9420

1999 • 89 citations

Oral verapamil with chemotherapy for advanced non-small cell lung cancer: a randomised study

1993 • 88 citations

Pharmacological characterization of LY335979: A potent cyclopropyldibenzosuberane modulator of P-glycoprotein

1997 • 86 citations

Phase I/II Study of the P-Glycoprotein Modulator PSC 833 in Patients With Acute Myeloid Leukemia

2001 • 85 citations

Phase I Study of Paclitaxel in Combination With a Multidrug Resistance Modulator, PSC 833 (Valspodar), in Refractory Malignancies

2000 • 83 citations

Decreased Mutation Rate for Cellular Resistance to Doxorubicin and Suppression of mdrl Gene Activation by the Cyclosporin PSC 833

1995 • 83 citations

Effects of MDR1 and MDR3 P-glycoproteins, MRP1, and BCRP/MXR/ABCP on the transport of 99mTc-tetrofosmin

2000 • 82 citations

Amplification of the ATP-binding cassette 2 transporter gene is functionally linked with enhanced efflux of estramustine in ovarian carcinoma cells.

1998 • 81 citations

A phase I trial of doxorubicin, paclitaxel, and valspodar (PSC 833), a modulator of multidrug resistance.

2001 • 79 citations

Multidrug resistance-associated protein in acute myeloid leukemia: No impact on treatment outcome.

1997 • 79 citations

Adhesion-dependent multicellular drug resistance.

1999 • 78 citations

Expression of the multidrug resistance-associated protein (MRP) gene in primary non-small-cell lung cancer

1996 • 76 citations

Epitope mapping of monoclonal antibodies specific for the 190-kDa multidrug resistance protein (MRP)

1998 • 74 citations

Phase I crossover study of paclitaxel with r-verapamil in patients with metastatic breast cancer.

1996 • 73 citations

Flow cytometric assay of modulation of P-glycoprotein function in whole blood by the multidrug resistance inhibitor GG918.

1996 • 67 citations

Efflux of Rhodamine From CD56+ Cells as a Surrogate Marker for Reversal of P-Glycoprotein–Mediated Drug Efflux by PSC 833

1999 • 64 citations

Quantitative reverse transcriptase-polymerase chain reaction measured expression of MDR1 and MRP in primary breast carcinoma.

1998 • 58 citations

Pharmacokinetics of vincristine in cancer patients treated with nifedipine

1989 • 54 citations

Expression of LRP and MDR1 in locally advanced breast cancer predicts axillary node invasion at the time of rescue mastectomy after induction chemotherapy

2001 • 53 citations

Expression of mediated P-glycoprotein multidrug resistance related to Tc-99m MIBI scintimammography results

2000 • 43 citations

Multidrug-Resistant Gene Expression in Small-Cell Lung Cancer

1997 • 43 citations

Co-expression of the MDR1 gene and HSP27 in human ovarian cancer.

1998 • 42 citations

Sufficient levels of quinine in the serum circumvent the multidrug resistance of the human leukemic cell line K562/ADM

1991 • 41 citations

P-glycoprotein expression at diagnosis may not be a primary mechanism of therapeutic failure in childhood rhabdomyosarcoma.

1996 • 41 citations

Do P-glycoprotein and major vault protein (MVP/LRP) expression correlate with in vitro daunorubicin resistance in acute myeloid leukemia?

1999 • 39 citations

The P-glycoprotein antagonist PSC 833 increases the plasma concentrations of 6alpha-hydroxypaclitaxel, a major metabolite of paclitaxel.

2001 • 38 citations

Expression of Functional Markers in Acute Nonlymphoblastic Leukemia

2000 • 37 citations

P-Glycoprotein and multidrug resistance-related protein expressions in relation to technetium-99m methoxyisobutylisonitrile scintimammography findings.

2001 • 36 citations

Incidence of P-glycoprotein overexpression and multidrug resistance (MDR) reversal in adult soft tissue sarcoma

2000 • 35 citations

Studies of Human MDR1-MDR2 Chimeras Demonstrate the Functional Exchangeability of a Major Transmembrane Segment of the Multidrug Transporter and Phosphatidylcholine Flippase

1999 • 33 citations

The clinical role of MDR1 gene expression in human lung cancer.

1997 • 26 citations

Calcium regulates estrogen increase in permeability of cultured CaSki epithelium by eNOS-dependent mechanism

2000 • 25 citations

Phase I Study of Intravenous PSC-833 and Doxorubicin: Reversal of Multidrug Resistance

2001 • 22 citations

EFFECT OF P-GLYCOPROTEIN EXPRESSION ON OUTCOME IN THE EWING FAMILY OF TUMORS

2001 • 21 citations