A variant 2677A allele of the gene affects fexofenadine disposition

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

2000 • 2,358 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 • 1,109 citations

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1990 • 1,063 citations

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

1998 • 1,058 citations

Identification of functionally variant MDR1 alleles among European Americans and African Americans

2001 • 1,000 citations

The superfamily of organic anion transporting polypeptides

2002 • 859 citations

Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects

2001 • 757 citations

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*

1997 • 675 citations

Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study

2002 • 670 citations

Fruit juices inhibit organic anion transporting polypeptide–mediated drug uptake to decrease the oral availability of fexofenadine

2002 • 604 citations

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine.

1999 • 585 citations

Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene.

2001 • 538 citations

Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16.

1988 • 443 citations

The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells

2001 • 377 citations

MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects.

2001 • 319 citations

Pharmacogenetics goes genomic

2003 • 318 citations

Modulation of steady‐state kinetics of digoxin by haplotypes of the P‐glycoprotein MDR1 gene

2002 • 307 citations

Contributions of hepatic and intestinal metabolism and P-glycoprotein to cyclosporine and tacrolimus oral drug delivery

1997 • 283 citations

Distinct haplotype profiles and strong linkage disequilibrium at the MDR1 multidrug transporter gene locus in three ethnic Asian populations

2002 • 281 citations

Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P‐glycoprotein

2002 • 268 citations

Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects

2002 • 266 citations

Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms.

1995 • 254 citations

MDR1 gene polymorphisms and disposition of the P‐glycoprotein substrate fexofenadine

2002 • 250 citations

Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients

2003 • 248 citations

The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans

2002 • 247 citations

The Mucosa of the Small Intestine

2002 • 230 citations

The drug efflux–metabolism alliance: biochemical aspects

2001 • 230 citations

Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs

2003 • 226 citations

The effects of the human MDR1 genotype on the expression of duodenal P‐glycoprotein and disposition of the probe drug talinolol

2002 • 201 citations

Digoxin pharmacokinetics and MDR1 genetic polymorphisms

2003 • 169 citations

Genetic Polymorphism in MDR-1: A Tool for Examining Allelic Expression in Normal Cells, Unselected and Drug-Selected Cell Lines, and Human Tumors

1998 • 157 citations

MDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white males

2002 • 153 citations

Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677: functional relevance to pharmacokinetics of digoxin.

2002 • 129 citations

Pharmacokinetic and prognostic significance of intestinal MDR1 expression in recipients of living‐donor liver transplantation

2001 • 125 citations

Human MDR1 polymorphism: G2677T/A and C3435T have no effect on MDR1 transport activities

2003 • 121 citations

Pharmacogenomics of organic anion-transporting polypeptides (OATP)

2002 • 112 citations

Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates.

2002 • 104 citations

Active intestinal secretion of the fluoroquinolone antibacterials ciprofloxacin, norfloxacin and pefloxacin; a common secretory pathway?

1994 • 94 citations

Determination of terfenadine and terfenadine acid metabolite in plasma using solid-phase extraction and high-performance liquid chromatography with fluorescence detection

1991 • 72 citations

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