Tacrolimus Dosing in Adult Lung Transplant Patients Is Related to Cytochrome P4503A5 Gene Polymorphism

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

2001 • 2,120 citations

PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing

1997 • 946 citations

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy

1995 • 856 citations

Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects

2001 • 757 citations

Clinical Pharmacokinetics of Tacrolimus

1995 • 749 citations

Automating the identification of DNA variations using quality-based fluorescence re-sequencing: analysis of the human mitochondrial genome

1998 • 506 citations

MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity

2001 • 418 citations

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery

1999 • 292 citations

P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans.

1996 • 266 citations

Tacrolimus Dosing in Pediatric Heart Transplant Patients is Related to CYP3A5 and MDR1 Gene Polymorphisms

2003 • 265 citations

VARIABLE ORAL ABSORPTION OF CYCLOSPORINE

1996 • 252 citations

The pharmacokinetics and metabolic disposition of tacrolimus: A comparison across ethnic groups

2001 • 201 citations

Bimodal distribution of renal cytochrome P450 3A activity in humans.

1996 • 178 citations

A MULTICENTER TRIAL OF FK506 (TACROLIMUS) THERAPY IN REFRACTORY ACUTE RENAL ALLOGRAFT REJECTION

1996 • 140 citations

Allele and genotype frequencies of CYP2B6 and CYP3A5 in the Japanese population

2002 • 135 citations

Tacrolimus is a class II low-solubility high-permeability drug: The effect of P-glycoprotein efflux on regional permeability of tacrolimus in rats

2002 • 133 citations

Effect of intestinal P-glycoprotein on daily tacrolimus trough level in a living-donor small bowel recipient

2000 • 110 citations

The MDR1 polymorphisms at exons 21 and 26 predict steroid weaning in pediatric heart transplant patients

2002 • 103 citations

Genetic polymorphism of cytochrome P450 3A5 in Chinese.

2001 • 81 citations

Effects of intestinal and hepatic metabolism on the bioavailability of tacrolimus in rats.

1998 • 69 citations

LOW BIOAVAILABILITY OF CYCLOSPORINE MICROEMULSION AND TACROLIMUS IN A SMALL BOWEL TRANSPLANT RECIPIENT

1999 • 55 citations