MDR-1 C3435T Polymorphism Influences Cyclosporine A Dose Requirement in Liver-Transplant Recipients

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

2000 • 2,358 citations

Pharmacogenomics — Drug Disposition, Drug Targets, and Side Effects

2003 • 1,750 citations

Human P-glycoprotein transports cyclosporin A and FK506.

1993 • 676 citations

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*

1997 • 675 citations

Update of the International Banff Schema for liver allograft rejection: Working recommendations for the histopathologic staging and reporting of chronic rejection

2000 • 511 citations

Modulation of steady‐state kinetics of digoxin by haplotypes of the P‐glycoprotein MDR1 gene

2002 • 307 citations

Contributions of hepatic and intestinal metabolism and P-glycoprotein to cyclosporine and tacrolimus oral drug delivery

1997 • 283 citations

Association of the Multidrug Resistance-1 Gene Single-Nucleotide Polymorphisms with the Tacrolimus Dose Requirements in Renal Transplant Recipients

2003 • 281 citations

No Influence of the MDR-1 C3435T Polymorphism or a CYP3A4 Promoter Polymorphism (CYP3A4-V Allele) on Dose-adjusted Cyclosporin A Trough Concentrations or Rejection Incidence in Stable Renal Transplant Recipients

2001 • 261 citations

Improved clinical outcomes for liver transplant recipients using cyclosporine monitoring based on 2-hr post-dose levels (C2)1

2002 • 195 citations

The Effect of CYP3A5 and MDR1 Polymorphic Expression on Cyclosporine Oral Disposition in Renal Transplant Patients

2003 • 162 citations

The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone

2002 • 105 citations

Modulation of multidrug resistance gene expression by dexamethasone in cultured hepatoma cells.

1993 • 84 citations

Recommendations for the Implementation of Neoral C2 Monitoring in Clinical Practice

2002 • 84 citations

Frequency Distribution of C3435T Mutation in Exon 26 of the MDR1 Gene in a Spanish Population

2003 • 75 citations

Amlodipine, but not MDR1 polymorphisms, alters the pharmacokinetics of cyclosporine A in Japanese kidney transplant recipients1

2003 • 56 citations

Modulation of mdr1a and CYP3A gene expression in the intestine and liver as possible cause of changes in the cyclosporin A disposition kinetics by dexamethasone

2002 • 48 citations

Monitoring Cyclosporin in Blood: Between-Assay Differences at Trough and 2 Hours Post-dose (C2)

2003 • 47 citations

MDR1 gene expression in peripheral blood mononuclear cells after liver transplantation1

2002 • 13 citations