Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis

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2001 • 5,526 citations

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

2001 • 4,997 citations

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1976 • 3,140 citations

Development of a Crohn's Disease Activity Index

1976 • 3,024 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

2000 • 2,358 citations

Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population.

1995 • 1,977 citations

Patterns of linkage disequilibrium in the human genome

2002 • 1,132 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Identification of functionally variant MDR1 alleles among European Americans and African Americans

2001 • 1,000 citations

Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance

2004 • 900 citations

Two stage genome–wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12

1996 • 713 citations

Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study

2002 • 670 citations

Frequency of glucocorticoid resistance and dependency in Crohn's disease.

1994 • 670 citations

Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1

2003 • 653 citations

A Novel Model of Inflammatory Bowel Disease: Mice Deficient for the Multiple Drug Resistance Gene,mdr1a, Spontaneously Develop Colitis

1998 • 570 citations

Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene

2003 • 420 citations

Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes

2001 • 378 citations

The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis

1998 • 357 citations

Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis

2003 • 323 citations

Genetic Polymorphisms of the HumanMDR1Drug Transporter

2003 • 308 citations

High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy

2000 • 289 citations

MDR1 Ala893 Polymorphism Is Associated with Inflammatory Bowel Disease

2003 • 240 citations

A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels

1998 • 232 citations

Glucocorticoid resistance in inflammatory bowel disease

2003 • 229 citations

Genomic evidence for recent positive selection at the human MDR1 gene locus

2004 • 96 citations

Tissue-specific enhancer of the human multidrug-resistance (MDR1) gene.

1990 • 69 citations

Common single nucleotide polymorphisms of the MDR1 gene have no influence on its mRNA expression level of normal kidney cortex and renal cell carcinoma in Japanese nephrectomized patients

2003 • 27 citations

The role of P-glycoprotein ( MDR1 ) polymorphisms and mutations in colorectal cancer

2001 • 23 citations