Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

1988 • 3,038 citations

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

1985 • 2,298 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

1989 • 1,030 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1974 • 695 citations

Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity

1991 • 513 citations

P‐glycoprotein: multidrug‐resistance and a superfamily of membrane‐associated transport proteins

1989 • 512 citations

DNA topoisomerase-targeting antitumor drugs can be studied in yeast.

1988 • 490 citations

Cloning and sequencing of a deoxyribonucleic acid copy of glyceraldehyde 3-phosphate dehydrogenase messenger ribonucleic acid isolated from chicken muscle

1983 • 486 citations

Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

1989 • 445 citations

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons.

1990 • 427 citations

Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors.

1987 • 412 citations

Modification of the hydroxylactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity

1989 • 406 citations

Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells.

1989 • 368 citations

Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor.

1992 • 363 citations

The cell biology of multiple drug resistance

1987 • 340 citations

Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies.

1972 • 315 citations

Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin.

1988 • 314 citations

Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.

1986 • 312 citations

Isolation of amplified and overexpressed DNA sequences from adriamycin-resistant human breast cancer cells.

1987 • 296 citations

An undifferentiated variant derived from the human acute myelogenous leukemia cell line (KG-1)

1980 • 272 citations

Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer.

1972 • 271 citations

Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin.

1989 • 260 citations

Preliminary pharmacologic and clinical evaluation of camptothecin sodium (NSC-100880).

1970 • 246 citations

Cloning and expression of a cDNA for human thioredoxin.

1988 • 239 citations

Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogs

1980 • 232 citations

Studies on the Antitumor Activity, Mechanism of Action, and Cell Cycle Effects of Camptothecin

1971 • 213 citations

Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo

1988 • 213 citations

Action of camptothecin on mammalian cells in culture.

1972 • 190 citations

Characterization of an Amsacrine-resistant Line of Human Leukemia Cells

1989 • 179 citations

A model for tumor cell killing by topoisomerase poisons.

1990 • 172 citations

Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer: Characterization and mechanism of resistance

1991 • 168 citations

Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line.

1991 • 165 citations

Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells.

1991 • 159 citations

Treatment of malignant melanoma with camptothecin (NSC-100880).

1972 • 158 citations

Camptothecin-induced in vivo topoisomerase I cleavages in the transcriptionally active tyrosine aminotransferase gene

1987 • 150 citations

Cell cycle phase specificity of antitumor agents.

1972 • 150 citations

ATP/Mg2+-dependent binding of vincristine to the plasma membrane of multidrug-resistant K562 cells.

1988 • 143 citations

Relationship between the intracellular effects of camptothecin and the inhibition of DNA topoisomerase I in cultured L1210 cells.

1987 • 141 citations

Effects of camptothecin on the breakage and repair of DNA during the cell cycle.

1973 • 140 citations

In vivo characteristics of resistance and cross-resistance of an adriamycin-resistant subline of P388 leukemia.

1978 • 135 citations

Camptothecin-resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I.

1988 • 125 citations

Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study

1988 • 121 citations

Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring A substituted camptothecin analogs. Structure-activity correlations

1987 • 113 citations

Laser flow cytometric studies on the intracellular fluorescence of anthracyclines.

1980 • 113 citations

High-performance liquid chromatographic analysis of the new antitumour drug SK&F 104864-A (NSC 609699) in plasma

1990 • 104 citations

Topoisomerase II levels during granulocytic maturation in vitro and in vivo.

1991 • 100 citations

Plant antitumor agents. 22. Isolation of 11-hydroxycamptothecin from Camptotheca acuminata decne: total synthesis and biological activity

1986 • 73 citations

Improved methods for the isolation of individual and clustered mitotic chromosomes

1987 • 72 citations

Association of topoisomerase II with the hepatoma cell nuclear matrix: The role of intermolecular disulfide bond formation

1991 • 60 citations

Potentiation of topoisomerase inhibitor-induced DNA strand breakage and cytotoxicity by tumor necrosis factor: enhancement of topoisomerase activity as a mechanism of potentiation.

1990 • 59 citations

Flow cytometric double labeling technique for screening of multidrug resistance

1991 • 38 citations

Das Resistenzproblem

1954 • 35 citations

New aspects of clinical drug resistance: the role of gene amplification and the reversal of resistance in drug refractory cancer.

1986 • 35 citations

Studies on therapeutic effectiveness of drugs with tumor weight and survival time indices of Walker 256 carcinosarcoma.

1968 • 29 citations

Effect of Exposure to Calcium Entry Blockers on Doxorubicin Accumulation and Cytotoxicity in Multidrug-Resistant Cells

1990 • 24 citations

Intrinsic multidrug resistance phenotype of chinese hamster (rodent) cells in comparison to human cells

1988 • 18 citations

An Alternative Approach to the Quantitation of Glucocorticoid-Receptor Complexes in the Nuclei of Lymphoid Cells*

1982 • 17 citations