Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1997 • 1,306 citations

Analysis of serum insulin-like growth factor binding proteins using Western blotting: Use of the method for titration of the binding proteins and competitive binding studies

1986 • 1,158 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

1999 • 744 citations

Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis

1996 • 661 citations

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

1998 • 571 citations

Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways

1996 • 538 citations

Apoptotic cell death and tissue remodelling during mouse mammary gland involution

1992 • 536 citations

Activation of the STAT Signaling Pathway Can Cause Expression of Caspase 1 and Apoptosis

1997 • 525 citations

Defective TNF-α-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases

1997 • 508 citations

Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution.

1992 • 445 citations

Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution

1997 • 371 citations

STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line.

1996 • 345 citations

Cell death by apoptosis during involution of the lactating breast in mice and rats

1989 • 341 citations

STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition

1998 • 251 citations

Glucocorticoid and progesterone inhibit involution and programmed cell death in the mouse mammary gland.

1995 • 238 citations

Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation.

1996 • 228 citations

Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.

1996 • 208 citations

The p53 tumour suppressor gene

1998 • 185 citations

p21/p53, Cellular Growth Control and Genomic Integrity

1998 • 177 citations

Identification of necrotic cell death by the TUNEL assay in the hypoxic-ischemic neonatal rat brain

1997 • 173 citations

Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression.

1996 • 164 citations

Stat5 as a Target for Regulation by Extracellular Matrix

1995 • 154 citations

Hormonal Control of Insulin-Like Growth Factor-Binding Protein-5 Production in the Involuting Mammary Gland of the Rat¹

1997 • 153 citations

Role of Angiotensin II in Activation of the JAK/STAT Pathway Induced by Acute Pressure Overload in the Rat Heart

1997 • 152 citations

Programmed cell death during mammary tissue involution induced by weaning, litter removal, and milk stasis

1996 • 146 citations

Approaches to the Manipulation of Mammary Involution

1989 • 131 citations

Bax and Bcl-xS are induced at the onset of apoptosis in involuting mammary epithelial cells

1996 • 121 citations

The role of prolactin and growth hormone in the regulation of casein gene expression and mammary cell survival: relationships to milk synthesis and secretion.

1996 • 114 citations

Ultrastructural detection of DNA strand breaks in apoptotic neural cells by in situ end‐labelling techniques

1995 • 112 citations

Clusterin Biogenesis Is Altered during Apoptosis in the Regressing Rat Ventral Prostate

1998 • 110 citations

Immunological Aspects of Mammary Involution

1989 • 110 citations

Differential activation of STATs 3 and 5 during mammary gland development

1996 • 108 citations

False positive staining in the TUNEL assay to detect apoptosis in liver and intestine is caused by endogenous nucleases and inhibited by diethyl pyrocarbonate

1998 • 105 citations

Transcription Factor AP-2 Regulates Human Insulin-like Growth Factor Binding Protein-5 Gene Expression

1995 • 101 citations

Efficient BLG-Cre mediated gene deletion in the mammary gland.

1998 • 99 citations

Keratin Expression in the Mammary Gland

1987 • 94 citations

Regulation of Cell Growth by IL-2: Role of STAT5 in Protection from Apoptosis But Not in Cell Cycle Progression

1998 • 90 citations

Delayed involution of the mammary epithelium in BALB/c-p53null mice

1998 • 87 citations

Apoptosis and remodeling of mammary gland tissue during involution proceeds through p53-independent pathways.

1996 • 79 citations

Survival factors and apoptosis

1998 • 62 citations

Peripheral T lymphocyte depletion by apoptosis after CD4 ligationin vivo: selective loss of CD44− and ‘activating’ memory T cells

1994 • 58 citations

Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation

1996 • 53 citations

Up-regulated P21CIP1 expression is part of the regulation quantitatively controlling serum deprivation-induced apoptosis

1997 • 51 citations

Activation of Stat-3 Is Involved in the Induction of Apoptosis After Ligation of Major Histocompatibility Complex Class I Molecules on Human Jurkat T Cells

1998 • 49 citations

The role of prolactin and growth hormone in the regulation of casein gene expression and mammary cell survival: relationships to milk synthesis and secretion

1996 • 38 citations

Positive Selection of Apoptosis-resistant Cells Correlates with Activation of Dominant-Negative STAT5

1998 • 33 citations

Transcriptional Regulation of the β-Casein Gene by Cytokines: Cross-Talk between STAT5 and Other Signaling Molecules

1998 • 32 citations

STAT3 activation is a critical step in gp130 mediated-terminal differentiation and growth arrest of a myeloid cell line

2000 • 31 citations

Hormonal Control of Insulin-Like Growth Factor-Binding Protein-5 Production in the Involuting Mammary Gland of the Rat

1997 • 29 citations

Programmed cell death during mammary tissue involution induced by weaning, litter removal, and milk stasis

1996 • 13 citations

Transcription Factor AP-2 Regulates Human Insulin-like Growth Factor Binding Protein-5 Gene Expression

1995 • 13 citations

Activation of Stat-3 Is Involved in the Induction of Apoptosis After Ligation of Major Histocompatibility Complex Class I Molecules on Human Jurkat T Cells

1998 • 9 citations

The Role of Growth Factors and Extracellular Matrix Proteases in Active Cell Death in the Prostate

1995 • 4 citations

Up‐regulated P21CIP1 expression is part of the regulation quantitatively controlling serum deprivation‐induced apoptosis

1997 • 4 citations