Mutations in the gene for the IL-7 receptor result in T–B+NK+ severe combined immunodeficiency disease

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

1998 • 1,293 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

1995 • 875 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses

1998 • 827 citations

Defective IL7R expression in T-B+NK+ severe combined immunodeficiency

1998 • 805 citations

Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development

1995 • 800 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

Hematopoietic Stem-Cell Transplantation for the Treatment of Severe Combined Immunodeficiency

1999 • 713 citations

THE MULTIFACETED REGULATION OF INTERLEUKIN-15 EXPRESSION AND THE ROLE OF THIS CYTOKINE IN NK CELL DIFFERENTIATION AND HOST RESPONSE TO INTRACELLULAR PATHOGENS

1999 • 712 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Interaction of IL-2Rβ and γ _c Chains with Jak1 and Jak3: Implications for XSCID and XCID

1994 • 647 citations

Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α

1999 • 642 citations

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

1997 • 603 citations

Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits

1994 • 581 citations

Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

1999 • 554 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

Human severe combined immunodeficiency: Genetic, phenotypic, and functional diversity in one hundred eight infants

1997 • 543 citations

Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

1997 • 503 citations

Xid -Like Immunodeficiency in Mice with Disruption of the p85α Subunit of Phosphoinositide 3-Kinase

1999 • 465 citations

Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes.

1995 • 376 citations

Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody.

1993 • 345 citations

The Earliest T Lineage–Committed Cells Depend on IL-7 for Bcl-2 Expression and Normal Cell Cycle Progression

1997 • 338 citations

Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

1998 • 331 citations

Stat5b Is Essential for Natural Killer Cell–mediated Proliferation and Cytolytic Activity

1998 • 323 citations

Prevention of T Cell Anergy by Signaling Through the γ _c Chain of the IL-2 Receptor

1994 • 311 citations

Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease

2000 • 306 citations

Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice.

1996 • 301 citations

An Indirect Effect of Stat5a in IL-2–Induced Proliferation: A Critical Role for Stat5a in IL-2–Mediated IL-2 Receptor α Chain Induction

1997 • 275 citations

T Cell Proliferation in Response to Interleukins 2 and 7 Requires p38MAP Kinase Activation

1997 • 254 citations

Interleukin-7: physiological roles and mechanisms of action

1999 • 243 citations

Thymic Stromal Lymphopoietin: A Cytokine That Promotes the Development of IgM+ B Cells In Vitro and Signals Via a Novel Mechanism

1999 • 231 citations

Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice

1997 • 220 citations

Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.

1996 • 211 citations

Distinct Roles of the Phosphatidylinositol 3-Kinase and STAT5 Pathways in IL-7-Mediated Development of Human Thymocyte Precursors

1999 • 205 citations

Requirement for Stat5 in Thymic Stromal Lymphopoietin-Mediated Signal Transduction

1999 • 181 citations

THE MOLECULAR BASIS OF X-LINKED SEVERE COMBINED IMMUNODEFICIENCY: Defective Cytokine Receptor Signaling

1996 • 168 citations

Characterization of thymic stromal‐derived lymphopoietin (TSLP) in murine B cell development in vitro

1996 • 160 citations

NATURALLY OCCURRING PRIMARY DEFICIENCIES OF THE IMMUNE SYSTEM

1997 • 159 citations

Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells.

1996 • 153 citations

STAM, Signal Transducing Adaptor Molecule, Is Associated with Janus Kinases and Involved in Signaling for Cell Growth and c-myc Induction

1997 • 144 citations

Interleukin‐7 induces the association of phosphatidylinositol 3‐kinase with the α chain of the interleukin‐7 receptor

1994 • 131 citations

Interleukin 7 Receptor Control of T Cell Receptor γ Gene Rearrangement: Role of Receptor-associated Chains and Locus Accessibility

1998 • 131 citations

In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development

1998 • 128 citations

Interleukin‐7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells

1995 • 127 citations

The role of cytokine receptor signaling in lymphocyte development

1999 • 118 citations

Close linkage of the locus for X chromosome-linked severe combined immunodeficiency to polymorphic DNA markers in Xq11-q13.

1987 • 108 citations

IL-7 Receptor and VDJ Recombination: Trophic Versus Mechanistic Actions

1997 • 108 citations

Natural and Engineered Disorders of Lymphocyte Development

1998 • 102 citations

Interleukin 7 receptor functions by recruiting the tyrosine kinase p59fyn through a segment of its cytoplasmic tail.

1992 • 92 citations

Both Stat5a and Stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue

2000 • 84 citations

The role of IL-7 in thymic and extrathymic development of TCR gamma delta cells.

1998 • 71 citations

JAK3 Janus kinase is involved in interleukin 7 signal pathway

1994 • 67 citations

Multiple γc-dependent cytokines regulate T-cell development

1999 • 66 citations

Biological and clinical implications of interleukin-7 and lymphopoiesis.

1999 • 66 citations

The Common Cytokine Receptor γ Chain Controls Survival of γ/δ T Cells

1997 • 64 citations

Pim1 Reconstitutes Thymus Cellularity in Interleukin 7–And Common γ Chain–Mutant Mice and Permits Thymocyte Maturation in Rag- but Not Cd3γ-Deficient Mice

1999 • 63 citations

The Role of IL-7 in Thymic and Extrathymic Development of TCRγδ Cells

1998 • 63 citations

Interleukin‐7 activates p56^lck and p59^fyn, two tyrosine kinases associated with the p90 interleukin‐7 receptor in primary human T cells

1995 • 62 citations

THE ROLE OF CASPASE 3 AND BclxLIN THE ACTION OF INTERLEUKIN 7 (IL-7): A SURVIVAL FACTOR IN ACTIVATED HUMAN T CELLS

1998 • 51 citations

Interleukin-7 (IL-7) Knockout Mice. Implications for Lymphopoiesis and Organ-Specific Immunity

1998 • 51 citations

Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity.

1999 • 41 citations

Role of Bcl-2 in αβ T Cell Development in Mice Deficient in the Common Cytokine Receptor γ-Chain: The Requirement for Bcl-2 Differs Depending on the TCR/MHC Affinity

1999 • 40 citations

Functional Role of Interleukin-4 (IL-4) and IL-7 in the Development of X-Linked Severe Combined Immunodeficiency

1999 • 35 citations

Signals from the IL-9 Receptor Are Critical for the Early Stages of Human Intrathymic T Cell Development

2000 • 35 citations

Differential association of phosphatidylinositol 3-kinase with insulin receptor substrate (IRS)-1 and IRS-2 in human thymocytes in response to IL-7.

1997 • 28 citations

INTERLEUKIN-7 RECEPTOR α CHAIN–DEPENDENT SIGNALING IS REQUIRED FOR T-CELL DEVELOPMENT

2000 • 7 citations

Inherited Cytokine and Cytokine Receptor Deficiencies in Man

1998 • 3 citations