Pim1 Reconstitutes Thymus Cellularity in Interleukin 7–And Common γ Chain–Mutant Mice and Permits Thymocyte Maturation in Rag- but Not Cd3γ-Deficient Mice

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors

1989 • 497 citations

Early T Lymphocyte Progenitors

1996 • 473 citations

Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.

1996 • 414 citations

Interleukin 7 receptor-deficient mice lack gammadelta T cells.

1996 • 316 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain

1996 • 268 citations

Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice.

1994 • 253 citations

Early αβ T cell development in the thymus of normal and genetically altered mice

1997 • 249 citations

Pim-1 Kinase and p100 Cooperate to Enhance c-Myb Activity

1998 • 249 citations

Involvement of c-myc in MuLV-induced T cell lymphomas in mice: frequency and mechanisms of activation.

1984 • 234 citations

Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice

1997 • 220 citations

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

1993 • 214 citations

CD3ε-mediated signals rescue the development of CD4⁺CD8⁺ thymocytes in RAG-2^−/− mice in the absence of TCR β chain expression

1994 • 205 citations

Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas.

1985 • 203 citations

The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases

1986 • 198 citations

Retroviral insertional mutagenesis as a strategy to identify cancer genes

1996 • 198 citations

Rearrangement and diversity of T cell receptor β chain genes in thymocytes: A critical role for the β chain in development

1993 • 198 citations

Pro-Thymocyte Expansion by c-kit and the Common Cytokine Receptor γ Chain Is Essential for Repertoire Formation

1997 • 195 citations

Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2.

1995 • 187 citations

Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally.

1991 • 173 citations

The Common γ-Chain for Multiple Cytokine Receptors

1995 • 168 citations

Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc

1997 • 159 citations

The CD3γ chain is essential for development of both the TCRαβ and TCRγδ lineages

1998 • 158 citations

An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

1994 • 157 citations

CD3 components at the surface of pro‐T cells can mediate pre‐T cell development in vivo

1994 • 156 citations

Role of the Common Cytokine Receptor γ Chain in Cytokine Signaling and Lymphoid Development

1995 • 143 citations

Molecular and Cellular Events in Early Thymocyte Development 11Received for publication October 14, 1997

1998 • 137 citations

In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development

1998 • 128 citations

Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice

1997 • 99 citations

KID-1, a Protein Kinase Induced by Depolarization in Brain

1998 • 94 citations

The Common Cytokine Receptor γ Chain and the Pre-T Cell Receptor Provide Independent but Critically Overlapping Signals in Early α/β T Cell Development

1999 • 88 citations

CD2ϵ and CD3ξ cytoplasmic domains can independently generate signals for T cell development and function

1995 • 85 citations

Evidence implicating Gfi-1 and Pim-1 in pre-T-cell differentiation steps associated with β-selection

1998 • 83 citations

Impaired interleukin-3 response in Pim-1-deficient bone marrow-derived mast cells

1993 • 80 citations

Functions of TCR and pre-TCR subunits: lessons from gene ablation

1996 • 77 citations

Pim-1 levels determine the size of early B lymphoid compartments in bone marrow.

1993 • 74 citations

Mice Bearing the Eµ-myc and Eµ-pim-l Transgenes Develop Pre-B-Cell Leukemia Prenatally

1991 • 47 citations

Transgenic mice as a means to study synergism between oncogenes

1989 • 34 citations

Domains of the TCR beta-chain required for early thymocyte development.

1996 • 30 citations

The effect of IL-2 treatment on transcriptional attenuation in proto-oncogenes pim-1 and c-myb in human thymic blast cells.

1996 • 28 citations

Analysis of Pim-1 function in mutant mice.

1993 • 27 citations