The role of Jak3 in lymphoid development, activation, and signaling

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

Cytokine receptor signalling

1995 • 1,242 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

1995 • 875 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development

1995 • 800 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Interaction of IL-2Rβ and γ _c Chains with Jak1 and Jak3: Implications for XSCID and XCID

1994 • 647 citations

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1995 • 571 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

Generalized autoimmune disease in interleukin‐2‐deficient mice is triggered by an uncontrolled activation and proliferation of CD4⁺ T cells

1995 • 423 citations

The Interleukin-2 Receptor γ Chain: Its Role in the Multiple Cytokine Receptor Complexes and T Cell Development in XSCID

1996 • 411 citations

Interleukin‐2 receptor common γ‐chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti‐apoptotic (bcl‐2, bcl‐x_L) but not pro‐apoptotic (bax, bcl‐x_S) gene expression

1996 • 367 citations

Abnormal Development of Intestinal Intraepithelial Lymphocytes and Peripheral Natural Killer Cells in Mice Lacking the IL-2 Receptor β Chain

1997 • 359 citations

Jak-STAT Signaling Induced by the v- abl oncogene

1995 • 341 citations

Interleukin 7 receptor-deficient mice lack gammadelta T cells.

1996 • 316 citations

Prevention of T Cell Anergy by Signaling Through the γ _c Chain of the IL-2 Receptor

1994 • 311 citations

Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice.

1996 • 301 citations

Normal clonal expansion but impaired Fasmediated cell death and anergy induction in interleukin‐2‐deficient mice

1995 • 234 citations

Interleukin-7: a Cofactor For V(D)J Rearrangement of the T Cell Receptor β Gene

1993 • 221 citations

The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis.

1996 • 213 citations

Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.

1996 • 211 citations

The Molecular Basis of X‐Linked Severe Combined Immunodeficiency: The Role of the Interleukin‐2 Receptor γ Chain as a Common γ Chain, γc

1994 • 180 citations

Protein tyrosine phosphatases in signaling

1996 • 170 citations

The Common Cytokine Receptor γ Chain Plays an Essential Role in Regulating Lymphoid Homeostasis

1997 • 168 citations

Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells.

1996 • 162 citations

Characterization of thymic stromal‐derived lymphopoietin (TSLP) in murine B cell development in vitro

1996 • 160 citations

Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells.

1996 • 153 citations

Interleukin-9 Induces Tyrosine Phosphorylation of Insulin Receptor Substrate-1 via JAK Tyrosine Kinases

1995 • 150 citations

Molecular Characterization of Specific Interactions between SHP-2 Phosphatase and JAK Tyrosine Kinases

1997 • 140 citations

Interleukins 2, 4, 7, and 15 Stimulate Tyrosine Phosphorylation of Insulin Receptor Substrates 1 and 2 in T Cells POTENTIAL ROLE OF JAK KINASES

1995 • 133 citations

The V–J Recombination of T Cell Receptor-γ Genes Is Blocked in Interleukin-7 Receptor–deficient Mice

1996 • 132 citations

Signaling via IL-2 and IL-4 in JAK3-Deficient Severe Combined Immunodeficiency Lymphocytes: JAK3-Dependent and Independent Pathways

1996 • 129 citations

Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells.

1995 • 121 citations

Role of interleukin-2 (IL-2), IL-7, and IL-15 in natural killer cell differentiation from cord blood hematopoietic progenitor cells and from gamma c transduced severe combined immunodeficiency X1 bone marrow cells

1996 • 119 citations

Signaling by IL-2 and related cytokines: JAKs, STATs, and relationship to immunodeficiency

1996 • 113 citations

Differential regulation of bcl-2 and bcl-x by CD3, CD28, and the IL-2 receptor in cloned CD4+ helper T cells. A model for the long-term survival of memory cells.

1996 • 110 citations

Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction.

1995 • 108 citations

gamma-c gene transfer into SCID X1 patients' B-cell lines restores normal high-affinity interleukin-2 receptor expression and function

1996 • 107 citations

Interaction between Sam68 and Src Family Tyrosine Kinases, Fyn and Lck, in T Cell Receptor Signaling

1997 • 103 citations

Peripheral Expression of Jak3 Is Required to Maintain T Lymphocyte Function

1997 • 89 citations

Correction of interleukin-2 receptor function in X-SCID lymphoblastoid cells by retrovirally mediated transfer of the gamma-c gene

1996 • 88 citations

A novel X-linked combined immunodeficiency disease.

1990 • 86 citations

JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3' kinase

1995 • 80 citations

Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells

1996 • 80 citations

Retroviral-mediated gene correction for X-linked severe combined immunodeficiency

1996 • 78 citations

IL-2 and IL-7 but not IL-12 protect natural killer cells from death by apoptosis and up-regulate bcl-2 expression.

1995 • 74 citations

Expression of Janus Kinase 3 in Human Endothelial and Other Non-lymphoid and Non-myeloid Cells

1996 • 74 citations

In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction.

1996 • 70 citations

Crucial Role of Jak3 in Negative Selection of Self-reactive T Cells

1997 • 69 citations

A Kinase-deficient Splice Variant of the Human JAK3 Is Expressed in Hematopoietic and Epithelial Cancer Cells

1995 • 65 citations

Critical role for the common cytokine receptor gamma chain in intrathymic and peripheral T cell selection.

1996 • 64 citations

Interleukin‐7 activates p56^lck and p59^fyn, two tyrosine kinases associated with the p90 interleukin‐7 receptor in primary human T cells

1995 • 62 citations

Protein kinases in human breast cancer

1995 • 60 citations

Genomic Sequence, Organization, and Chromosomal Localization of HumanJAK3

1996 • 55 citations

The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes.

1996 • 53 citations

Il-7 supports D-J but not V-DJ rearrangement of TCR-beta gene in fetal liver progenitor cells.

1996 • 53 citations

A transgenic T cell receptor restores thymocyte differentiation in interleukin-7 receptor α chain-deficient mice

1997 • 51 citations

Interleukin-4 induces association of the c-fes proto-oncogene product with phosphatidylinositol-3 kinase

1996 • 51 citations

IL‐2 Signaling Involves Recruitment and Activation of Multiple Protein Tyrosine Kinases by the IL‐2 Receptor^a

1995 • 50 citations

The common gamma-chain of cytokine receptors regulates intrathymic T cell development at multiple stages.

1997 • 48 citations

Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor γ _c chain for Janus kinase activation leading to T cell proliferation

1997 • 47 citations

Dysfunctional cytokine receptor signaling in severe combined immunodeficiency.

1996 • 27 citations

Coupling of the IL2 receptor complex with non-receptor protein tyrosine kinases.

1996 • 26 citations

Evidence for a Role of Phosphatidylinositol 3-Kinase in IL-4-Induced Germline Cϵ Transcription

1996 • 25 citations

Structural organization and chromosomal mapping of JAK3 locus.

1996 • 22 citations

Immunodeficiencies caused by genetic defects in protein kinases

1996 • 20 citations

Disruption of Cytokine Signaling in Lymphoid Development: Unique Contributions of the Common Cytokine Gamma Chain and the Jak3 Kinase

1996 • 14 citations

Genomic Structure and Promoter Region of the Murine Janus-Family Tyrosine Kinase, Jak3

1997 • 12 citations

Jak3 maps to Chromosome 8

1996 • 7 citations