Dendritic Cells in Transplantation—Friend or Foe?

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

2001 • 1,384 citations

Consequences of Cell Death

2000 • 1,382 citations

The immune system evolved to discriminate infectious nonself from noninfectious self

1992 • 1,324 citations

Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo

2000 • 1,286 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

1α,25-Dihydroxyvitamin D3 Inhibits Differentiation, Maturation, Activation, and Survival of Dendritic Cells Leading to Impaired Alloreactive T Cell Activation

2000 • 1,253 citations

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

2000 • 908 citations

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization

1999 • 898 citations

Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells.

1982 • 807 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance

2000 • 723 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Migration and maturation of Langerhans cells in skin transplants and explants.

1990 • 663 citations

Efficient Presentation of Phagocytosed Cellular Fragments on the Major Histocompatibility Complex Class II Products of Dendritic Cells

1998 • 649 citations

Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells

1999 • 564 citations

Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells

2000 • 483 citations

Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity

1998 • 480 citations

Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survivalin vivo

2000 • 477 citations

Mobilizing Dendritic Cells for Tolerance, Priming, and Chronic Inflammation

1999 • 474 citations

The Leukotriene C4 Transporter MRP1 Regulates CCL19 (MIP-3β, ELC)–Dependent Mobilization of Dendritic Cells to Lymph Nodes

2000 • 456 citations

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.

1993 • 442 citations

The Development, Maturation, and Turnover Rate of Mouse Spleen Dendritic Cell Populations

2000 • 418 citations

The Formation of Immunogenic Major Histocompatibility Complex Class II–Peptide Ligands in Lysosomal Compartments of Dendritic Cells Is Regulated by Inflammatory Stimuli

2000 • 412 citations

COSTIMULATORY MOLECULE-DEFICIENT DENDRITIC CELL PROGENITORS (MHC CLASS II+, CD80dim, CD86-) PROLONG CARDIAC ALLOGRAFT SURVIVAL IN NONIMMUNOSUPPRESSED RECIPIENTS12

1996 • 378 citations

Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways.

1994 • 354 citations

Human Cd4+ T Lymphocytes Consistently Respond to the Latent Epstein-Barr Virus Nuclear Antigen Ebna1

2000 • 340 citations

CD4+ T Cell Help Impairs CD8+ T Cell Deletion Induced by Cross-presentation of Self-Antigens and Favors Autoimmunity

1997 • 320 citations

CD4+ T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow–derived Antigen-presenting Cells

1998 • 300 citations

INDIRECT ALLORECOGNITION OF MAJOR HISTOCOMPATIBILITY COMPLEX ALLOPEPTIDES IN HUMAN RENAL TRANSPLANT RECIPIENTS WITH CHRONIC GRAFT DYSFUNCTION1

1997 • 290 citations

The molecular basis of alloreactivity

1990 • 278 citations

On the complexity of self

1991 • 261 citations

The lost chord: microchimerism and allograft survival

1996 • 259 citations

Mice lacking major histocompatibility complex class I and class II molecules.

1993 • 259 citations

Indirect recognition of donor HLA-DR peptides in organ allograft rejection.

1996 • 244 citations

A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production.

1996 • 238 citations

Dendritic Cells Genetically Engineered to Express Fas Ligand Induce Donor-Specific Hyporesponsiveness and Prolong Allograft Survival

2000 • 237 citations

THE ROLE OF AFFERENT LYMPHATICS IN THE REJECTION OF SKIN HOMOGRAFTS

1968 • 224 citations

How Many Thymocytes Audition for Selection?

1997 • 222 citations

Immature Dendritic Cells Acquire Cd8+Cytotoxic T Lymphocyte Priming Capacity upon Activation by T Helper Cell–Independent or–Dependent Stimuli

2000 • 195 citations

CD4 T cell–mediated cardiac allograft rejection requires donor but not host MHC class II

2000 • 182 citations

Glucocorticoids transform CD40-triggering of dendritic cells into an alternative activation pathway resulting in antigen-presenting cells that secrete IL-10

2000 • 178 citations

Antigen Concentration and Precursor Frequency Determine the Rate of CD8+ T Cell Tolerance to Peripherally Expressed Antigens

1999 • 174 citations

DELETION OF SPONTANEOUS RAT LIVER ALLOGRAFT ACCEPTANCE BY DONOR IRRADIATION

1995 • 173 citations

RETROVIRAL DELIVERY OF VIRAL INTERLEUKIN-10 INTO MYELOID DENDRITIC CELLS MARKEDLY INHIBITS THEIR ALLOSTIMULATORY ACTIVITY AND PROMOTES THE INDUCTION OF T-CELL HYPORESPONSIVENESS1,2

1998 • 163 citations

Activation of Transplant Immunity: Effect of Donor Leukocytes on Thyroid Allograft Rejection

1976 • 159 citations

Immunogenicity of retransplanted rat kidney allografts. Effect of inducing chimerism in the first recipient and quantitative studies on immunosuppression of the second recipient.

1982 • 145 citations

Antigen processing and presentation in transplantation

1996 • 140 citations

Significant Frequencies of T Cells With Indirect Anti-Donor Specificity in Heart Graft Recipients With Chronic Rejection

2000 • 140 citations

Experimental Studies on the Pathogenesis of Contact Eczema in the Guinea-Pig

1957 • 136 citations

Assessment of the Contribution That Direct Allorecognition Makes to the Progression of Chronic Cardiac Transplant Rejection in Humans

1998 • 132 citations

INDIRECT RECOGNITION OF DONOR HLA CLASS I PEPTIDES IN LUNG TRANSPLANT RECIPIENTS WITH BRONCHIOLITIS OBLITERANS SYNDROME1

1999 • 127 citations

Successful Allotransplantation of Mouse Pancreatic Islets to Nonimmunosuppressed Recipients

1980 • 124 citations

Thymus and autoimmunity: capacity of the normal thymus to produce pathogenic self-reactive T cells and conditions required for their induction of autoimmune disease.

1990 • 120 citations

A Basis for Alloreactivity: MHC Helical Residues Broaden Peptide Recognition by the TCR

1998 • 110 citations

PHENOTYPE, FUNCTION, AND IN VIVO MIGRATION AND SURVIVAL OF ALLOGENEIC DENDRITIC CELL PROGENITORS GENETICALLY ENGINEERED TO EXPRESS TGF-??1,2

1998 • 108 citations

Antigen presentation by epithelial cells induces anergic immunoregulatory CD45RO+ T cells and deletion of CD45RA+ T cells.

1997 • 87 citations

Peripheral tolerance of CD4 T cells following local activation in adolescent mice

1996 • 82 citations

MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I PEPTIDE-PULSED HOST DENDRITIC CELLS INDUCE ANTIGEN-SPECIFIC ACQUIRED THYMIC TOLERANCE TO ISLET CELLS 1,2

2000 • 82 citations

CYTOKINE AND CHEMOKINE EXPRESSION KINETICS AFTER CORNEAL TRANSPLANTATION1

2000 • 82 citations

Vigorous Allograft Rejection in the Absence of Danger

2000 • 81 citations

Critical Requirement for Graft Passenger Leukocytes in Allograft Tolerance Induced by Donor Blood Transfusion

1998 • 77 citations

Detection of donor-specific hyporesponsiveness following late failure of human renal allografts

1996 • 70 citations

Interferon-γ-treated renal tubular epithelial cells induce allospecific tolerance

1998 • 64 citations

THE ROLE OF THE ALLOGRAFT IN THE INDUCTION OF DONOR-SPECIFIC T CELL HYPORESPONSIVENESS

2001 • 61 citations

A DENDRITIC CELL LINE GENETICALLY MODIFIED TO EXPRESS CTLA4-IG AS A MEANS TO PROLONG ISLET ALLOGRAFT SURVIVAL12

2000 • 60 citations

ACQUIRED SYSTEMIC TOLERANCE TO RAT CARDIAC ALLOGRAFTS INDUCED BY INTRATHYMIC INOCULATION OF SYNTHETIC POLYMORPHIC MHC CLASS I ALLOPEPTIDES1,2

1996 • 52 citations

REPLACEMENT OF GRAFT-RESIDENT DONOR-TYPE ANTIGEN PRESENTING CELLS ALTERS THE TEMPO AND PATHOGENESIS OF MURINE CARDIAC ALLOGRAFT REJECTION1

2000 • 44 citations

Oral feeding of an immunodominant MHC donor-derived synthetic class I peptide prolongs graft survival of heterotopic cardiac allografts in a high-responder rat strain combination

2000 • 38 citations

Anterior Chamber-Associated Immune Deviation

1999 • 33 citations

Tolerance to Antigen-Presenting Cell-Depleted Islet Allografts Is CD4 T Cell Dependent

1999 • 31 citations

The Lost Chord

2009 • 23 citations