The molecular basis of alloreactivity

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

1988 • 1,161 citations

Association of class I major histocompatibility heavy and light chains induced by viral peptides

1989 • 995 citations

Isolation and characterization of antigen-la complexes involved in T cell recognition

1986 • 470 citations

Why do so many lymphocytes respond to major histocompatibility antigens?

1977 • 462 citations

Differential function of major histocompatibility complex antigens in T-lymphocyte activation

1976 • 419 citations

T Cell Selection in the Thymus

1988 • 405 citations

DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression.

1985 • 340 citations

Polymorphism of human Ia antigens: gene conversion between two DR β loci results in a new HLA-D/DR specificity

1986 • 292 citations

T cells can distinguish between allogeneic major histocompatibility complex products on different cell types

1988 • 246 citations

High determinant density may explain the phenomenon of alloreactivity

1984 • 194 citations

Sequence polymorphism of HLA DRβ1 alleles relating to T-cell-recognized determinants

1985 • 183 citations

Inhibition of alloreactive cytotoxic T lymphocytes by peptides from the α2 domain of HLA–A2

1987 • 146 citations

HLA-A2 peptides can regulate cytolysis by human allogeneic T lymphocytes

1987 • 132 citations

An estimation of the frequency of precursor cells which generate cytotoxic lymphocytes.

1976 • 123 citations

Polymorphism of human Ia antigens generated by reciprocal intergenic exchange between two DR β loci

1986 • 111 citations

The molecular basis of alloreactivity in antigen-specific, major histocompatibility complex-restricted T cell clones

1987 • 96 citations

Complete characterization and sequence of an HLA class II DR beta chain cDNA from the DR5 haplotype.

1986 • 95 citations

Functionally distinct subsites on a class II major histocompatibility complex molecule

1987 • 95 citations

Histocompatibility antigen-activated cytotoxic T lymphocytes. I. Estimates of the absolute frequency of killer cells generated in vitro.

1977 • 95 citations

Structure-function analysis of the Abm12 beta mutation using site-directed mutagenesis and DNA-mediated gene transfer.

1987 • 86 citations

Specificity of T-cell clones illustrates altered self hypothesis

1981 • 82 citations

Co-recognition of endogenous antigens with HLA-DR1 by alloreactive human T cell clones.

1989 • 76 citations

DNA typing of DRw6 subtypes: Correlation with DRB1 and DRB3 allelic sequences by hybridization with oligonucleotide probes

1989 • 73 citations

Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes.

1988 • 61 citations

Microheterogeneity of HLA-DR4 haplotypes: DNA sequence analysis of LD“KT2” and LD“TAS” haplotypes

1987 • 56 citations

The development of helper T cell precursors in mouse thymus.

1988 • 50 citations

First domain sequence of the HLA-DRB1 chain from two HLA-DRw14 homozygous typing cell lines: TEM (Dw9) and AMALA (Dw16)

1989 • 46 citations

Selective modification of a private I-A allo-stimulating determinant(s) upon association of antigen with an antigen-presenting cell.

1984 • 45 citations

The ability of cytotoxic T cells to recognize HLA-A2.1 or HLA-B7 antigens expressed on murine cells correlates with their epitope specificity.

1987 • 41 citations

Structural and functional studies of HLA-DR restricted antigen recognition by human helper T lymphocyte clones by using transfected murine cell lines.

1988 • 39 citations

Species-restricted recognition of transfected HLA-A2 and HLA-B7 by human CTL clones.

1986 • 38 citations

T cells recognize antigen alone and not MHC molecules

1987 • 17 citations