CD4+ T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow–derived Antigen-presenting Cells

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

A role for CD95 ligand in preventing graft rejection

1995 • 1,184 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

B Cells Turn Off Virgin But Not Memory T Cells

1992 • 578 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.

1992 • 435 citations

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.

1994 • 418 citations

Self-Nonself Discrimination by T Cells

1990 • 331 citations

Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion.

1996 • 330 citations

A Nondeletional Mechanism of Thymic Self Tolerance

1989 • 322 citations

Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cells

1984 • 318 citations

T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I–E

1989 • 238 citations

Peripheral Clonal Elimination of Functional T Cells

1990 • 213 citations

The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen

1994 • 181 citations

Coexpression of B7-1 and viral (“self”) transgenes in pancreatic β cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes

1995 • 177 citations

Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness.

1994 • 163 citations

Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells.

1989 • 156 citations

Conditions That Induce Tolerance in Mature CD4+ T Cells

1997 • 149 citations

Peripheral deletion of autoreactive CD8⁺ T cells in transgenic mice expressing H‐2K^b in the liver

1995 • 138 citations

Dendritic cells and tolerance induction

1996 • 128 citations

Response elements of the androgen-regulated C3 gene.

1992 • 119 citations

Tolerance in Transgenic Mice Expressing Major Histocompatibility Molecules Extrathymically on Pancreatic Cells

1990 • 117 citations

Prostatic steroid-binding protein. Isolation and characterization of C3 genes.

1983 • 96 citations

Antigen‐presenting cells in adoptively transferred and spontaneous autoimmune diabetes

1993 • 91 citations

Peripheral deletion of mature CD8+ antigen-specific T cells after in vivo exposure to male antigen.

1992 • 84 citations

Peripheral tolerance of CD4 T cells following local activation in adolescent mice

1996 • 82 citations

T-cell tolerance and autoimmunity in transgenic models of central and peripheral tolerance

1994 • 64 citations

Down-regulation of CD8 on mature antigen-reactive T cells as a mechanism of peripheral tolerance.

1995 • 54 citations

Peripheral tolerance through clonal deletion of mature CD4⁻CD8⁺ T cells

1992 • 49 citations

The role of macrophages in antigen presentation and T cell tolerance

1993 • 42 citations

Tissue-Specific and Hormonal Regulation of the Gene for Rat Prostatic Steroid-Binding Protein in Transgenic Mice

1989 • 40 citations

Response elements of the androgen-regulated C3 gene.

1992 • 15 citations