Antigen processing and presentation in transplantation

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

1976 • 951 citations

T Cell-Dependent B Cell Activation

1993 • 727 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

1995 • 532 citations

Helper activity is required for the in vivo generation of cytotoxic T lymphocytes

1982 • 511 citations

Indirect presentation of MHC antigens in transplantation

1994 • 362 citations

The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice.

1993 • 325 citations

Successful T cell priming in B cell-deficient mice.

1995 • 284 citations

Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection.

1992 • 266 citations

Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo.

1994 • 227 citations

Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides.

1992 • 218 citations

Two levels of help for B cell alloantibody production.

1996 • 212 citations

Xenogeneic skin graft rejection is especially dependent on CD4+ T cells.

1989 • 206 citations

MECHANISMS OF T CELL RECOGNITION OF ALLOANTIGEN

1994 • 205 citations

Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection.

1987 • 198 citations

Antigen presentation to cytotoxic T lymphocytes in vivo.

1995 • 168 citations

EFFECT OF ORGAN CULTURE ON THE SURVIVAL OF THYROID ALLOGRAFTS IN MICE

1976 • 159 citations

MONITORING OF SOLUBLE HLA ALLOANTIGENS AND ANTI-HLA ANTIBODIES IDENTIFIES HEART ALLOGRAFT RECIPIENTS AT RISK OF TRANSPLANT-ASSOCIATED CORONARY ARTERY DISEASE1

1996 • 147 citations

Xenogeneic proliferation and lymphokine production are dependent on CD4+ helper T cells and self antigen-presenting cells in the mouse.

1990 • 141 citations

Three‐cell‐type clusters of T cells with antigen‐presenting cells best explain the epitope linkage and noncognate requirements of the in vivo cytolytic response

1987 • 141 citations

MECHANISMS OF ACQUIRED THYMIC UNRESPONSIVENESS TO RENAL ALLOGRAFTS

1994 • 129 citations

Dendritic Cells: Antigen Presentation, Accessory Function and Clinical Relevance

1993 • 124 citations

T cell recognition of allo-peptides in context of syngeneic MHC

1991 • 98 citations

MECHANISMS OF ALLO-RECOGNITION

1994 • 94 citations

CTLA4Ig PROLONGS ALLOGRAFT SURVIVAL WHILE SUPPRESSING CELL-MEDIATED IMMUNITY

1994 • 94 citations

Immunogenicity and tolerogenicity of self-major histocompatibility complex peptides.

1990 • 91 citations

INDEFINITE SURVIVAL OF MHC CLASS I-DEFICIENT MURINE PANCREATIC ISLET ALLOGRAFTS

1992 • 86 citations

INDIRECT T CELL ALLORECOGNITION OF DONOR ANTIGENS CONTRIBUTES TO THE REJECTION OF VASCULARIZED KIDNEY ALLOGRAFTS

1995 • 74 citations

THE INDIRECT PATHWAY OF ALLORECOGNITION

1995 • 74 citations

Survival of MHC-deficient mouse heterotopic cardiac allografts.

1995 • 70 citations

PEPTIDES DERIVED FROM α-HELICES OF ALLOGENEIC CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS ARE POTENT INDUCERS OF CD4+ AND CD8+ T CELL AND B CELL RESPONSES AFTER CARDIAC ALLOGRAFT REJECTION

1995 • 69 citations

Evidence that the effector mechanism of skin allograft rejection is antigen-specific.

1988 • 56 citations

Human endothelial stimulation of allogeneic T cells via a CTLA-4 independent pathway

1994 • 33 citations

FINE SPECIFICITY OF PEPTIDE DETERMINANTS FOR INDIRECT T CELL RECOGNITION OF CLASS I MHC ALLOANTIGENS

1994 • 32 citations

The role of direct and indirect antigen presentation in the response to islet xenografts.

1992 • 27 citations

Effector cells must recognize antigens expressed in the graft to cause efficient skin graft rejection in SCID mice.

1995 • 26 citations

Genetically engineered grafts to study xenoimmunity: a role for indirect antigen presentation in the destruction of major histocompatibility complex antigen deficient xenografts.

1994 • 25 citations

Influence of HLA class I and class II antigens on the peripheral T-cell receptor repertoire

1994 • 25 citations

Indirect recognition of native HLA alloantigens and B-cell help.

1995 • 23 citations

The failure of a major histocompatibility antigen to stimulate a thyroid allograft reaction after culture in oxygen.

1983 • 22 citations

Immunologically nonspecific mechanisms of tissue destruction in the rejection of skin grafts.

1994 • 20 citations

Donor-Specific Unresponsiveness to Murine Cardiac Allografts Induced by Intrathymic-Soluble Alloantigens Is Dependent on Alternate Pathway of Antigen Presentation

1995 • 20 citations

IN VITRO RECALL OF PROLIFERATIVE AND CYTOLYTIC RESPONSES TO MINOR HISTOCOMPATIBILITY ANTIGENS BY DENDRITIC CELL ENRICHED CANINE PERIPHERAL BLOOD MONONUCLEAR CELLS

1995 • 15 citations

Alloantigenicity of human endothelial cells. III. Quantitated indirect presentation of endothelial alloantigens to human helper T lymphocytes.

1994 • 12 citations

Elucidation of key peptide determinants involved in an indirect T-cell allorecognition pathway of rat kidney allograft rejection.

1995 • 4 citations

Induction of acute rejection by indirect recognition of donor MHC antigens.

1995 • 3 citations