A Basis for Alloreactivity: MHC Helical Residues Broaden Peptide Recognition by the TCR

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

The outline structure of the T-cell alpha beta receptor.

1988 • 625 citations

Why do so many lymphocytes respond to major histocompatibility antigens?

1977 • 462 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

Antigen-Specific Development of Primary and Memory T Cells in Vivo

1995 • 444 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

The Molecular Basis of Allorecognition

1993 • 398 citations

Correlations between T-cell specificity and the structure of the antigen receptor

1986 • 375 citations

Structures of an MHC Class II Molecule with Covalently Bound Single Peptides

1996 • 369 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

MHC Ligands and Peptide Motifs

1997 • 336 citations

Identification of High Potency Microbial and Self Ligands for a Human Autoreactive Class II–restricted T Cell Clone

1997 • 320 citations

INDIRECT ALLORECOGNITION OF MAJOR HISTOCOMPATIBILITY COMPLEX ALLOPEPTIDES IN HUMAN RENAL TRANSPLANT RECIPIENTS WITH CHRONIC GRAFT DYSFUNCTION1

1997 • 290 citations

A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein

1992 • 286 citations

Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.

1993 • 238 citations

On the nature of peptides involved in T cell alloreactivity.

1991 • 220 citations

Specific T cell recognition of minimally homologous peptides: Evidence for multiple endogenous Ligands

1995 • 209 citations

High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.

1994 • 200 citations

The Specificity and Orientation of a TCR to its Peptide–MHC Class II Ligands

1996 • 177 citations

T Cell Receptor Recognition of MHC Class II–Bound Peptide Flanking Residues Enhances Immunogenicity and Results in Altered TCR V Region Usage

1997 • 174 citations

Cross‐reactive memory T cells for Epstein‐Barr virus augment the alloresponse to common human leukocyte antigens: degenerate recognition of major histocompatibility complex‐bound peptide by T cells and its role in alloreactivity

1997 • 166 citations

B6.C-H-2bm12. A new H-2 mutation in the I region in the mouse.

1979 • 161 citations

Expression of a class II major histocompatibility complex (MHC) heterodimer in a lipid-linked form with enhanced peptide/soluble MHC complex formation at low pH.

1991 • 143 citations

A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity.

1996 • 131 citations

Complete dissection of the Hb(64-76) determinant using T helper 1, T helper 2 clones, and T cell hybridomas.

1992 • 131 citations

Antigen recognition by T lymphocytes

1972 • 120 citations

Peptide-induced conformational changes in class I heavy chains alter major histocompatibility complex recognition.

1992 • 118 citations

Direct evidence for functional self-protein/Ia-molecule complexes in vivo.

1988 • 111 citations

Major histocompatibility complex conformational epitopes are peptide specific.

1992 • 108 citations

The molecular basis of alloreactivity in antigen-specific, major histocompatibility complex-restricted T cell clones

1987 • 96 citations

Evidence that the antigen receptors of cytotoxic T lymphocytes interact with a common recognition pattern on the H-2Kb molecule

1995 • 89 citations

Allorecognition of DR1 by T cells from a DR4/DRw13 responder mimics self-restricted recognition of endogenous peptides.

1989 • 87 citations

Role of endogenous peptides in murine allogenic cytotoxic T cell responses assessed using transfectants of the antigen-processing mutant 174xCEM.T2.

1992 • 83 citations

Molecular genetic analysis of 178 I-Abm12-reactive T cells.

1989 • 76 citations

Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones

1996 • 72 citations

Recognition by Class II Alloreactive T Cells of Processed Determinants from Human Serum Proteins

1991 • 72 citations

Molecular basis for the recognition of two structurally different major histocompatibility complex/peptide complexes by a single T-cell receptor

1996 • 71 citations

Major histocompatibility complex class II-associated peptides control the presentation of bacterial superantigens to T cells.

1996 • 70 citations

Antagonism of superantigen-stimulated helper T-cell clones and hybridomas by altered peptide ligand.

1994 • 68 citations

Structurally interdependent and independent regions of allelic polymorphism in class II MHC molecules. Implications for Ia function and evolution.

1990 • 67 citations

Class I-Restricted Alloreactive Cytotoxic T Lymphocytes Recognize a Complex Array of Specific MHC-Associated Peptides

1998 • 62 citations

Use of combinatorial peptide libraries to construct functional mimics of tumor epitopes recognized by MHC class I-restricted cytolytic T lymphocytes.

1996 • 59 citations

Conformational differences in major histocompatibility complex-peptide complexes can result in alloreactivity.

1994 • 54 citations

Changes in cytokine secretion induced by altered peptide ligands of myelin basic protein peptide 85-99.

1997 • 50 citations

A Structural Model for TCR Recognition of the HLA Class II Shared Epitope Sequence Implicated in Susceptibility to Rheumatoid Arthritis

1996 • 49 citations

Modulation of T cell development by an endogenous altered peptide ligand.

1995 • 45 citations

The molecular basis of class II MHC allelic control of T cell responses.

1991 • 44 citations

Single-residue changes in class I major histocompatibility complex molecules stimulate responses to self peptides.

1992 • 43 citations

Natural ligand motifs of H-2E molecules are allele specific and illustrate homology to HLA-DR molecules

1995 • 41 citations

Alloreactive 2C T cells recognize a self peptide in the context of the mutant Kbm3 molecule.

1995 • 38 citations

Differential contact of disparate class I/peptide complexes as the basis for epitope cross-recognition by a single T cell receptor.

1997 • 37 citations

A residue in the center of peptide QL9 affects binding to both Ld and the T cell receptor.

1996 • 35 citations

Position 71 in the α helix of the DRβ domain is predicted to influence peptide binding and plays a central role in allorecognition

1993 • 32 citations

The role of self peptides in the allogeneic cross-reactivity of CTLs.

1995 • 31 citations

Inhibition of an In Vitro CD4+ T Cell Alloresponse Using Altered Peptide Ligands

1998 • 31 citations

TCR recognition of the Hb(64-76)/I-Ek determinant: single conservative amino acid changes in the complementarity-determining region 3 dramatically alter antigen fine specificity.

1996 • 30 citations

The orientation of a T cell receptor to its MHC class II:peptide ligands.

1997 • 28 citations

Alloreactivity, Antigen Recognition and T-Cell Selection: Three Diverse T-Cell Recognition Problems with a Common Solution

1996 • 28 citations

Amino acid changes in the peptide binding site have structural consequences at the surface of class I glycoproteins.

1993 • 18 citations

The Role of Peptide Specificity in MHC Class I‐Restricted Allogeneic Responses

1996 • 16 citations

V alpha 3.2 selection in MHC class I mutant mice: evidence for an alternate orientation of TCR-MHC class I interaction.

1997 • 15 citations

A single amino acid substitution in the A^k molecule fortuitously provokes an alloresponse

1991 • 11 citations

Sequence analysis of MHC class II Eb cDNAs from H2 r and H2 p haplotypes

1996 • 5 citations