Recent advances in graft‐versus‐host disease (GVHD) prevention

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Copolymer 1 reduces relapse rate and improves disability in relapsing‐remitting multiple sclerosis

1995 • 1,903 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Macrophage deactivation by interleukin 10.

1991 • 1,253 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

1987 • 1,209 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

1995 • 1,097 citations

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

1994 • 1,066 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 • 976 citations

Structure-Based Strategies for Drug Design and Discovery

1992 • 972 citations

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1994 • 950 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

1975 • 908 citations

Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.

1996 • 849 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

1992 • 839 citations

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

1993 • 837 citations

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.

1992 • 818 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells.

1996 • 788 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

The role of IL-10 in crossregulation of TH1 and TH2 responses

1991 • 775 citations

T-cell depletion of HLA-identical transplants in leukemia

1991 • 771 citations

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

1991 • 752 citations

Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity.

1996 • 746 citations

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

1990 • 745 citations

Specific Acceptance of Cardiac Allograft After Treatment with Antibodies to ICAM-1 and LFA-1

1992 • 737 citations

IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.

1992 • 709 citations

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

1990 • 699 citations

The Adjuvant Effect of Interleukin-12 in a Vaccine Against Leishmania major

1994 • 687 citations

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.

1994 • 681 citations

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

1994 • 630 citations

Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation.

1993 • 628 citations

H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;.

1975 • 623 citations

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.

1993 • 622 citations

Cytokine dysregulation and acute graft-versus-host disease

1992 • 617 citations

Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin.

1990 • 613 citations

Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease.

1987 • 609 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

A retrospective analysis of therapy for acute graft-versus-host disease: secondary treatment

1991 • 577 citations

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

1995 • 577 citations

Cytokine dysregulation and acute graft-versus-host disease

1992 • 565 citations

Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1.

1993 • 563 citations

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.

1992 • 558 citations

Expression of Interleukin-10 Activity by Epstein-Barr Virus Protein BCRF1

1990 • 539 citations

Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease

1995 • 535 citations

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

1995 • 532 citations

A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2

1990 • 527 citations

Purification and characterization of the Fas-ligand that induces apoptosis.

1994 • 521 citations

The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.

1992 • 518 citations

Effects of in vitro depletion of T cells in HLA-identical allogeneic marrow grafts

1985 • 517 citations

Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation

1993 • 517 citations

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion.

1993 • 502 citations

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.

1993 • 494 citations

CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.

1996 • 492 citations

Prevention of Collagen-Induced Arthritis with an Antibody to gp39, the Ligand for CD40

1993 • 471 citations

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

1991 • 445 citations

Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.

1986 • 439 citations

Human T cell antigens defined by monoclonal antibodies: the 65,000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin.

1980 • 429 citations

Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand.

1995 • 426 citations

Inducible T cell antigen 4-1BB. Analysis of expression and function.

1993 • 416 citations

High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.

1994 • 413 citations

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

1987 • 391 citations

IL-10: a novel cytotoxic T cell differentiation factor.

1991 • 391 citations

Molecular Biology and Function of CD4 and CD8

1989 • 388 citations

Macrophage priming and lipopolysaccharide-triggered release of tumor necrosis factor alpha during graft-versus-host disease.

1992 • 385 citations

IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function.

1992 • 375 citations

A new murine CD4+ T cell subset with an unrestricted cytokine profile.

1989 • 374 citations

IL-10, a novel growth cofactor for mature and immature T cells.

1990 • 371 citations

The Roles of Costimulation and Fas in T Cell Apoptosis and Peripheral Tolerance

1996 • 367 citations

RELEASE OF TUMOR NECROSIS FACTOR, INTERLEUKIN-2, AND GAMMA-INTERFERON IN SERUM AFTER INJECTION OF OKT3 MONOCLONAL ANTIBODY IN KIDNEY TRANSPLANT RECIPIENTS

1989 • 361 citations

Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody.

1990 • 360 citations

Biological properties of interleukin 10

1992 • 359 citations

Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.

1993 • 357 citations

Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.

1991 • 355 citations

Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand

1990 • 353 citations

Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.

1991 • 349 citations

Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen

1987 • 348 citations

Interleukin‐4 and interleukin‐10 synergize to inhibit cell‐mediated immunity in vivo

1993 • 341 citations

CTLA4 mediates antigen-specific apoptosis of human T cells.

1995 • 331 citations

Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

1995 • 326 citations

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.

1995 • 323 citations

Induction of antitumor immunity using bone marrow-generated dendritic cells.

1996 • 323 citations

Identification and distribution of the costimulatory receptor CD28 in the mouse.

1992 • 316 citations

Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease.

1996 • 310 citations

Interleukin‐10 controls interferon‐γ and tumor necrosis factor production during experimental endotoxemia

1994 • 306 citations

The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice.

1996 • 303 citations

The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells.

1996 • 303 citations

HEART ALLOGRAFTS IN MURINE SYSTEMS

1992 • 299 citations

Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.

1994 • 293 citations

Diversity of the Immunoglobulin Gene Superfamily

1989 • 293 citations

Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34.

1994 • 284 citations

The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response.

1996 • 284 citations

Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype.

1994 • 282 citations

Functional expression of B7/BB1 on activated T lymphocytes.

1993 • 271 citations

Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 Å resolution

1992 • 268 citations

A Phase I Trial of a Synthetic Mucin Peptide Vaccine

1996 • 268 citations

Structure-based inhibitor design by using protein models for the development of antiparasitic agents.

1993 • 265 citations

Expression and functional significance of an additional ligand for CTLA-4.

1993 • 262 citations

CD40 is functionally expressed on human thymic epithelial cells.

1992 • 261 citations

Hierarchical Control of Lymphocyte Survival

1996 • 255 citations

In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice

1994 • 245 citations

GRAFT REJECTION IN RECIPIENTS OF T-CELL-DEPLETED HLA-NONIDENTICAL MARROW TRANSPLANTS FOR LEUKEMIA

1987 • 241 citations

Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences.

1986 • 229 citations

Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding

1989 • 227 citations

Studies on the interdependence of gp39 and B7 expression and function during antigen‐specific immune responses

1995 • 225 citations

Isolated human follicular dendritic cells display a unique antigenic phenotype.

1989 • 225 citations

IL-4 plays a dominant role in the differential development of Tho into Th1 and Th2 cells.

1992 • 223 citations

CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation.

1992 • 220 citations

GRAFT REJECTION IN RECIPIENTS OF T-CELL-DEPLETED HLA-NONIDENTICAL MARROW TRANSPLANTS FOR LEUKEMIA

1987 • 220 citations

A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire.

1994 • 216 citations

T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells.

1988 • 212 citations

SYNERGISTIC INTERACTIONS OF CYCLOSPORINE AND RAPAMYCIN TO INHIBIT IMMUNE PERFORMANCES OF NORMAL HUMAN PERIPHERAL BLOOD LYMPHOCYTES IN VITRO

1991 • 205 citations

In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice

1994 • 205 citations

B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance.

1993 • 205 citations

Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease.

1995 • 204 citations

T _H 1 and T _H 2 Cell Antigen Receptors in Experimental Leishmaniasis

1993 • 204 citations

Isolation and characterization of human tonsil dendritic cells.

1988 • 201 citations

The CD40 ligand expressed by human B cells costimulates B cell responses.

1995 • 200 citations

Effects of in vivo administration of anti-CD3 monoclonal antibody on T cell function in mice. II. In vivo activation of T cells.

1989 • 198 citations

Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis.

1995 • 194 citations

Molecular interactions mediating T-B lymphocyte collaboration in human lymphoid follicles. Roles of T cell-B-cell-activating molecule (5c8 antigen) and CD40 in contact-dependent help.

1992 • 194 citations

Differential cytokine expression in acute and chronic murine graft‐versus‐host‐disease

1993 • 194 citations

Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation.

1997 • 193 citations

Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease.

1994 • 187 citations

Inability of CD8α′polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo

1989 • 183 citations

Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host disease

1991 • 180 citations

Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP.

1995 • 178 citations

Phase I-II trial of a monoclonal anti-tumor necrosis factor alpha antibody for the treatment of refractory severe acute graft-versus-host disease

1992 • 176 citations

Role of CD4 and CD8 in T Cell Activation and Differentiation

1993 • 172 citations

Treatment of acute graft-versus-host disease with humanized anti-Tac: an antibody that binds to the interleukin-2 receptor

1994 • 170 citations

Variable capacity of L3T4+ T cells to cause lethal graft-versus-host disease across minor histocompatibility barriers in mice.

1987 • 170 citations

Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft- versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice

1994 • 159 citations

Selective depletion of myelin–reactive T cells with the anti–OX–40 antibody ameliorates autoimmune encephalomyelitis

1996 • 159 citations

Phase I trial of an interleukin-2 (IL-2) fusion toxin (DAB486IL-2) in hematologic malignancies expressing the IL-2 receptor

1992 • 159 citations

A major role for the Fas pathway in acute graft-versus-host disease.

1996 • 158 citations

Protective effects of IL-4 and IL-10 against immune complex-induced lung injury.

1993 • 156 citations

Copolymer 1 inhibits chronic relapsing experimental allergic encephalomyelitis induced by proteolipid protein (PLP) peptides in mice and interferes with PLP-specific T cell responses

1996 • 155 citations

Costimulation through CD28 enhances T cell-dependent B cell activation via CD40-CD40L interaction.

1994 • 154 citations

The MHC-Binding and gp120-Binding Functions of CD4 Are Separable

1989 • 151 citations

In the absence of a CD40 signal, B cells are tolerogenic

1995 • 149 citations

Induction of B cell costimulatory function by recombinant murine CD40 ligand

1994 • 148 citations

Mutational analysis of the interaction between CD4 and class II MHC: Class II antigens contact CD4 on a surface opposite the gp120-binding site

1991 • 146 citations

Inhibition of alloreactive cytotoxic T lymphocytes by peptides from the α2 domain of HLA–A2

1987 • 146 citations

Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts

1995 • 144 citations

Interleukin‐4 and interleukin‐10 synergize to inhibit cell‐mediated immunity in vivo

1993 • 142 citations

Graft-versus-host-disease-associated lymphoid hypoplasia and B cell dysfunction is dependent upon donor T cell-mediated Fas-ligand function, but not perforin function

1997 • 141 citations

A rationally designed CD4 analogue inhibits experimental allergic encephalomyelitis

1994 • 139 citations

Phase I-II trial of a monoclonal anti-tumor necrosis factor alpha antibody for the treatment of refractory severe acute graft-versus-host disease

1992 • 139 citations

Engineering antibody Fv fragments for cancer detection and therapy: Bisulfide-stabilized Fv fragments

1996 • 138 citations

Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate graft- versus-host disease and extend the donor pool

1996 • 138 citations

Allospecific CD8+ Tc1 and Tc2 populations in graft-versus-leukemia effect and graft-versus-host disease.

1996 • 137 citations

Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein.

1996 • 134 citations

Interleukin 10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary mixed lymphocyte cultures

1992 • 133 citations

IL-12 stimulates the development of acute graft-versus-host disease in mice that normally would develop chronic, autoimmune graft-versus-host disease.

1994 • 131 citations

Dendritic Cells as Carriers for a Cytotoxic T-Lymphocyte Epitope-Based Peptide Vaccine in Protection Against a Human Papillomavirus Type 16-Induced Tumor

1995 • 131 citations

Interleukin-12 inhibits murine graft-versus-host disease

1995 • 128 citations

CTLA4Ig TREATMENT AMELIORATES THE LETHALITY OF MURINE GRAFT-VERSUS-HOST DISEASE ACROSS MAJOR HISTOCOMPATIBILITY COMPLEX BARRIERS

1994 • 123 citations

Phase I trial of an interleukin-2 (IL-2) fusion toxin (DAB486IL-2) in hematologic malignancies expressing the IL-2 receptor

1992 • 121 citations

Infusion of anti-B7.1 (CD80) and anti-B7.2 (CD86) monoclonal antibodies inhibits murine graft-versus-host disease lethality in part via direct effects on CD4+ and CD8+ T cells.

1996 • 120 citations

CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy.

1994 • 119 citations

Coblockade of the LFA1:ICAM and CD28/CTLA4:B7 pathways is a highly effective means of preventing acute lethal graft-versus-host disease induced by fully major histocompatibility complex-disparate donor grafts

1995 • 119 citations

B7/BB1, the ligand for CD28, is expressed on repeatedly activated human T cells in vitro

1993 • 117 citations

Critical role of interleukin-2 in the development of acute graft-versus-host disease

1993 • 117 citations

Apoptosis of mouse naive T cells induced by recombinant soluble Fas ligand and activation-induced resistance to Fas ligand.

1996 • 116 citations

T‐Cell Immunotherapy of Tumors by Adoptive Transfer of Cytotoxic T Lymphocytes and by Vaccination with Minimal Essential Epitopes

1995 • 115 citations

The Depletion of T Cell Subsets in Vitro and in Vivo

1986 • 105 citations

Interferon-gamma suppresses T-cell proliferation to mitogen via the nitric oxide pathway during experimental acute graft-versus-host disease

1996 • 105 citations

Role of T cell subsets in lethal graft-versus-host disease (GVHD) directed to class I versus class II H-2 differences. I. L3T4+ cells can either augment or retard GVHD elicited by Lyt-2+ cells in class I different hosts.

1988 • 104 citations

Nitric oxide mediates intestinal pathology in graft-vs.-host disease

1992 • 103 citations

T-cell antigen receptor transmembrane peptides modulate T-cell function and T cell-mediated disease

1997 • 103 citations

Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to its human counterpart, Leu-2/T8, and to immunoglobulin variable regions.

1985 • 101 citations

Cytokine release syndrome induced by the 145-2C11 anti-CD3 monoclonal antibody in mice: prevention by high doses of methylprednisolone.

1991 • 99 citations

T CELL DEPLETION FOR GRAFT-VERSUS-HOST-DISEASE PROPHYLAXIS

1989 • 98 citations

Induction of allograft tolerance in rats by an HLA class-I-derived peptide and cyclosporine A.

1994 • 97 citations

Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival.

1994 • 94 citations

L3T4-positive T cells participate in the induction of graft-vs-host disease in response to minor histocompatibility antigens.

1987 • 92 citations

B7/CD28-dependent and -independent induction of CD40 ligand expression.

1995 • 91 citations

Anti-CD2 antibodies induce T cell unresponsiveness in vivo.

1991 • 90 citations

Evaluation of a CD5-specific immunotoxin for treatment of acute graft- versus-host disease after allogeneic marrow transplantation

1996 • 90 citations

Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses.

1988 • 88 citations

Identification of a novel thymocyte growth-promoting factor derived from B cell lymphomas

1990 • 88 citations

CD2 regulates responsiveness of activated T cells to interleukin 12.

1995 • 87 citations

T cell depletion in bone marrow transplantation.

1988 • 85 citations

Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signals

1996 • 83 citations

In utero transfer of adult bone marrow cells into recipients with severe combined immunodeficiency disorder yields lymphoid progeny with T- and B-cell functional capabilities

1995 • 82 citations

Repeated treatment with chimeric anti‐CD4 antibody in multiple sclerosis

1994 • 82 citations

GRAFT-VERSUS-HOST DISEASE PREVENTION IN ALLOGENEIC BONE MARROW TRANSPLANTATION FROM HISTOCOMPATIBLE SIBLINGS A PILOT STUDY USING IMMUNOTOXINS FOR T CELL DEPLETION OF DONOR BONE MARROW

1987 • 81 citations

A role for nonspecific (cyclosporin A) or specific (monoclonal antibodies to ICAM-1, LFA-1, and IL-10) immunomodulation in the prolongation of skin allografts after antigen-specific pretransplant immunization or transfusion.

1994 • 79 citations

The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions

1985 • 79 citations

Reciprocal expression of co‐stimulatory molecules, B7‐1 and B7‐2, on murine T cells following activation

1995 • 78 citations

CD40 ligand‐positive CD8⁺ T cell clones allow B cell growth and differentiation

1995 • 74 citations

Induction of T helper cell hyporesponsiveness in an experimental model of autoimmunity by using nonmitogenic anti-CD3 monoclonal antibody.

1994 • 72 citations

Analysis of the monocyte Fc receptors and antibody-mediated cellular interactions required for the induction of T cell proliferation by anti-T3 antibodies.

1985 • 68 citations

Murine recipients of fully mismatched donor marrow are protected from lethal graft-versus-host disease by the in vivo administration of rapamycin but develop an autoimmune-like syndrome.

1993 • 68 citations

A computer screening approach to immunoglobulin superfamily structures and interactions: Discovery of small non-peptidic CD4 inhibitors as novel immunotherapeutics

1997 • 65 citations

HLA-derived peptides which inhibit T cell function bind to members of the heat-shock protein 70 family.

1996 • 65 citations

Mutations in CD8 that affect interactions with HLA class I and monoclonal anti-CD8 antibodies.

1991 • 64 citations

TREATMENT OF ACUTE GRAFT-VERSUS-HOST DISEASE WITH A NONMITOGENIC ANTI-CD3 MONOCLONAL ANTIBODY

1992 • 63 citations

Kaposi's sarcoma (KS)-associated herpesvirus-like DNA sequences in peripheral blood mononuclear cells: association with KS and persistence in patients receiving anti-herpesvirus drugs

1996 • 62 citations

Monoclonal antibodies to human tumor necrosis factor α: In vitro and in vivo application

1990 • 62 citations

Antibody engineering of recombinant Fv immunotoxins for improved targeting of cancer: disulfide-stabilized Fv immunotoxins.

1996 • 62 citations

IL-12 protects bone marrow from and sensitizes intestinal tract to ionizing radiation.

1994 • 62 citations

Genetically Engineered Toxins

2020 • 61 citations

Induction of alloantigen-specific tolerance by B cells from CD40-deficient mice.

1996 • 60 citations

Bone Marrow Transplantation

1993 • 60 citations

EFFECTS OF EXOGENOUS INTERLEUKIN-10 IN A MURINE MODEL OF GRAFT-VERSUS-HOST DISEASE TO MINOR HISTOCOMPATIBILITY ANTIGENS

1994 • 60 citations

The Role of B7 Costimulation by Murine Acute Myeloid Leukemia in the Generation and Function of a CD8+ T-Cell Line With Potent In Vivo Graft-Versus-Leukemia Properties

1997 • 59 citations

Mammalian expression and secretion of functional single-chain Fv molecules

1994 • 58 citations

Characterization of the immunosuppressive effects of nitric oxide in graft vs host disease.

1993 • 56 citations

Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers.

1995 • 56 citations

A PHASE I-II STUDY EVALUATING THE MURINE ANTI-IL-2 RECEPTOR ANTIBODY 2A3 FOR TREATMENT OF ACUTE GRAFT-VERSUS-HOST DISEASE

1990 • 56 citations

Induction of specific nonresponsiveness in unprimed human T cells by anti-CD3 antibody and alloantigen.

1990 • 55 citations

Location of CD4 dimerization site explains critical role of CDR3-like region in HIV-1 infection and T-cell activation and implies a model for complex of coreceptor-MHC

1993 • 55 citations

TREATMENT OF ACUTE GRAFT-VERSUS-HOST DISEASE WITH MONOCLONAL ANTIBODY OKT3

1984 • 52 citations

Role of Mast Cells in Early Epithelial Target Cell Injury in Experimental Acute Graft-Versus-Host Disease

1994 • 50 citations

Nonmitogenic anti-CD3F(ab')2 fragments inhibit lethal murine graft-versus-host disease induced across the major histocompatibility barrier.

1993 • 48 citations

The combination of anti-B7 monoclonal antibody and cyclosporin A induces alloantigen-specific anergy during a primary mixed lymphocyte reaction.

1994 • 47 citations

Involvement of α1 and α4 integrins in gut mucosal injury of graft-versus-host disease

1995 • 47 citations

Acute graft-versus-host reaction can be aborted by blockade of costimulatory molecules.

1995 • 46 citations

In vivo administration of anti-CD3 monoclonal antibodies or immunotoxins in murine recipients of allogeneic T cell-depleted marrow for the promotion of engraftment.

1991 • 45 citations

A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo.

1996 • 45 citations

T CELL DEPLETION WITH ANTI-CD5 IMMUNOTOXIN IN HISTOCOMPATIBLE BONE MARROW TRANSPLANTATION

1990 • 44 citations

REJECTION IN HEART TRANSPLANTATION STRONGLY CORRELATES WITH HLA-DR ANTIGEN MISMATCH

1994 • 43 citations

Effects of treating marrow with a CD3-specific immunotoxin for prevention of acute graft-versus-host disease.

1988 • 43 citations

Treatment of Multiple Sclerosis with Anti-CD4 Monoclonal Antibody

1993 • 41 citations

Characterization of cells emerging at the time of graft failure after bone marrow transplantation from an unrelated marrow donor

1993 • 40 citations

Use of anti-CD3 epsilon F(ab')2 fragments in vivo to modulate graft-versus-host disease without loss of graft-versus-leukemia reactivity after MHC-matched bone marrow transplantation.

1995 • 38 citations

Mechanism of graft failure in HLA-matched and HLA-mismatched bone marrow transplant recipients.

1989 • 38 citations

Peptides corresponding to the CD8 and CD4 binding domains of HLA molecules block T lymphocyte immune responses in vitro.

1994 • 38 citations

Treatment of Acute Graft-Versus-Host Disease With Anti-CD3 Monoclonal Antibodies

1988 • 37 citations

Prevention of acute GVHD by in vivo use of anti-interleukin-2 receptor monoclonal antibody (33B3.1): a feasibility trial in 15 patients.

1991 • 37 citations

Immunotoxins: will their clinical promise be fulfilled? [editorial]

1994 • 36 citations

A Synthetic CD4-CDR3 Peptide Analog Enhances Bone Marrow Engraftment Across Major Histocompatibility Barriers

1997 • 34 citations

ANTI-CD2 MONOCLONAL ANTIBODIES ALTER CELL-MEDIATED IMMUNITY IN VIVO

1991 • 33 citations

Anti-graft-versus-host disease effect of DT390-anti-CD3sFv, a single- chain Fv fusion immunotoxin specifically targeting the CD3 epsilon moiety of the T-cell receptor

1996 • 32 citations

Interleukin-1 or tumor necrosis factor-alpha antagonists do not inhibit graft-versus-host disease induced across the major histocompatibility barrier in mice.

1995 • 31 citations

Synergy between cyclosporin A and a monoclonal antibody to B7 in blocking alloantigen-induced T-cell activation

1994 • 31 citations

Monoclonal antibodies that specifically recognize crystals of dinitrobenzene

1996 • 30 citations

Immunotoxins: will their clinical promise be fulfilled? [editorial]

1994 • 30 citations

FK506 inhibits graft-versus-host disease and bone marrow graft rejection in murine recipients of MHC disparate donor grafts by interfering with mature peripheral T cell expansion post-transplantation.

1994 • 29 citations

In vivo or in vitro anti-CD3 epsilon chain monoclonal antibody therapy for the prevention of lethal murine graft-versus-host disease across the major histocompatibility barrier in mice.

1994 • 29 citations

In vivo inhibition of cytokine responsiveness and graft-versus-host disease mortality by rapamycin leads to a clinical-pathological syndrome discrete from that observed with cyclosporin A

1996 • 28 citations

Inhibitory effect of a CD4-CDR3 peptide analog on graft-versus-host disease across a major histocompatibility complex-haploidentical barrier

1996 • 28 citations

CD2 and the regulation of T cell anergy.

1995 • 27 citations

Prevention of graft-versus-host disease by peptides binding to class II major histocompatibility complex molecules

1994 • 26 citations

Neonatal induction of transplantation tolerance in mice is associated with in vivo expression of IL-4 and -10 mRNAs.

1993 • 26 citations

Identification of a Human CD4-CDR3-like Surface Involved in CD4+ T Cell Function

1996 • 25 citations

Antigenic modulation by anti-CD5 immunotoxins.

1986 • 25 citations

REGULATION OF CYTOTOXIC T LYMPHOCYTE-MEDIATED GRAFT REJECTION FOLLOWING BONE MARROW

1988 • 24 citations

A CD4-CDR3 peptide analog inhibits both primary and secondary autoreactive CD4+ T cell responses in experimental allergic encephalomyelitis.

1996 • 23 citations

Dysfunctional cytokine production by host-reactive T-cell clones isolated from a chimeric severe combined immunodeficiency patient transplanted with haploidentical bone marrow

1995 • 22 citations

Signal transduction by B7/BB1 expressed on activated T lymphocytes: cross-linking of B7/BB1 induces protein tyrosine phosphorylation and synergizes with signalling through T-cell receptor/CD3.

1995 • 22 citations

The role of T cell subsets in regulating the in vivo efficacy of CTLA4-Ig in preventing graft-versus-host disease in recipients of fully MHC or multiple minor histocompatibility-disparate donor inocula.

1994 • 22 citations

Adhesion molecule expression in human hepatic graft-versus-host disease.

1992 • 22 citations

Induction of alloantigen-specific T cell tolerance through the treatment of human T lymphocytes with wortmannin.

1997 • 21 citations

Rapamycin Prolongs Survival of Murine Recipients of Fully Allogeneic Donor Grafts When Administered during the Graft‐versus‐Host Disease Processa

1993 • 21 citations

Increased ICAM-1 Expression in the Early Stages of Murine Chronic Graft-versus-Host Disease

1994 • 20 citations

THE MECHANISM OF UNRESPONSIVENESS TO ALLOGRAFTS INDUCED BY RAPAMYCIN AND RAPAMYCIN/CYCLOSPORINE TREATMENT IN RATS

1993 • 19 citations

Prevention and Treatment of Allograft Rejection in Vivo by Rapamycin: Molecular and Cellular Mechanisms of Action

1993 • 19 citations

EVIDENCE THAT FK506 AND RAPAMYCIN BLOCK T CELL ACTIVATION AT DIFFERENT SITES RELATIVE TO EARLY REVERSIBLE PHOSPHORYLATION INVOLVING THE PROTEIN PHOSPHATASES PP1 AND PP2A

1991 • 19 citations

Four ricin chain A-based immunotoxins directed against the common chronic lymphocytic leukemia antigen: in vitro characterization

1993 • 18 citations

Cytotoxicity of chimeric (human-murine) monoclonal antibody BR96 IgG, F(ab')2, and Fab' conjugated to Pseudomonas exotoxin

1992 • 17 citations

Effects of anti-CD3 monoclonal antibody on engraftment of T-cell- depleted bone marrow allografts in mice: host T-cell suppression, growth factors, and space

1992 • 16 citations

Modelling in peptide design

1989 • 16 citations

SINGLE AS WELL AS PAIRS OF SYNERGISTIC ANTI-CD4+CD8 ANTIBODIES PREVENT GRAFT-VERSUS-HOST DISEASE IN FULLY MISMATCHED MICE

1994 • 16 citations

Identification, by protein sequencing and gene transfection, of sgp-60 as the murine homologue of CD48.

1993 • 15 citations

RATIONALE FOR THE SELECTION OF RICIN A-CHAIN ANTI-T IMMUNOTOXINS FOR MATURE T CELL DEPLETION

1987 • 15 citations

Rational design of a peptide analog of the L3T4 CDR3-like region

1992 • 14 citations

Effects of anti-CD3 monoclonal antibody on engraftment of T-cell- depleted bone marrow allografts in mice: host T-cell suppression, growth factors, and space

1992 • 14 citations

Therapy for ongoing graft-versus-host disease induced across the major or minor histocompatibility barrier in mice with anti-CD3F(ab')2-ricin toxin A chain immunotoxin

1995 • 13 citations

Efficient tumor eradication by adoptively transferred cytotoxic T-cell clones in allogeneic hosts

1996 • 12 citations

EFFECTS OF EXOGENOUS INTERLEUKIN-10 IN A MURINE MODEL OF GRAFT-VERSUS-HOST DISEASE TO MINOR HISTOCOMPATIBILITY ANTIGENS

1994 • 11 citations

Segregation of reactivity to the mitogens lipopolysaccharide, lipoprotein and dextran sulfate in clones of the B cell lymphoma line WEHI 279.1

1985 • 11 citations

A novel 120‐kDa antigen shared by immature human thymocytes and long‐term‐activated T cells

1994 • 10 citations

EAE: A Model for Immune Intervention with Synthetic Peptides

1992 • 9 citations

Evaluation of anti-CD5 ricin A chain immunoconjugate for prevention of acute graft-vs.-host disease after HLA-identical marrow transplantation.

1994 • 9 citations

Prevention of lethal graft-versus-host disease in mice by monoclonal antibodies directed against T cells or their subsets. I. Evidence for the induction of a state of tolerance based on suppression.

1994 • 8 citations

Activation of T lymphocytes to M locus determinants in vivo.. I. Quantitation of T cell proliferation and migration into thoracic duct lymph

1976 • 8 citations

Depletion of bone marrow T-lymphocytes with an anti-CD5 monoclonal immunotoxin (ST-1 immunotoxin): effective prophylaxis for graft-versus-host disease.

1990 • 6 citations

Prolonged survival of mouse cardiac allografts after CD4 or CD8 monoclonal antibody therapy is associated with selective intragraft cytokine protein expression: interleukin (IL)-4 and IL-10 but not IL-2 or interferon-gamma.

1993 • 4 citations

Efficacy of anti-CD5 F(AB′)2 and FAB′ immunoconjugates in human peripheral blood lymphocyte-reconstituted severe combined immunodeficient mice

1993 • 4 citations

Tumor necrosis factor alpha in human bone marrow recipients [letter; comment]

1990 • 4 citations

The Photoelectric Effect as Related to the Size and Surface Conditions of Carbon Particles

1929 • 1 citations

[Expression of adhesion molecules in hepatic graft-versus-host disease].

1994 • 1 citations