Mutations in CD8 that affect interactions with HLA class I and monoclonal anti-CD8 antibodies.

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

Sequences of proteins of immunological interest

1984 • 3,427 citations

The Immunoglobulin Superfamily—Domains for Cell Surface Recognition

1988 • 2,237 citations

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

1979 • 1,989 citations

The differentiation and function of human T lymphocytes

1980 • 1,548 citations

Tertiary templates for proteins

1987 • 1,485 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Canonical structures for the hypervariable regions of immunoglobulins

1987 • 1,357 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.

1987 • 802 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

1988 • 716 citations

The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus

1990 • 709 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

1990 • 549 citations

Crystal structure of an HIV-binding recombinant fragment of human CD4

1990 • 545 citations

A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2

1990 • 527 citations

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

1989 • 447 citations

Cell-cell adhesion mediated by CD8 and MHC class I molecules

1988 • 445 citations

Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells.

1984 • 365 citations

Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4

1988 • 294 citations

Molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI refined at 2.0-Å resolution

1975 • 266 citations

Polymorphism in the α3 domain of HLA-A molecules affects binding to CD8

1989 • 247 citations

Rapid and Efficient Site-Specific Mutagenesis without Phenotypic Selection

1989 • 233 citations

Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes.

1987 • 228 citations

Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding

1989 • 227 citations

Substitution at residue 227 of H–2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes

1989 • 198 citations

RIBBON: a stereo cartoon drawing program for proteins

1988 • 190 citations

Interleukin-4 mediates CDS induction on human CD4+ T-cell clones

1988 • 163 citations

Synergism in the activation of human CD8 T cells by cross-linking the T-cell receptor complex with the CD8 differentiation antigen.

1986 • 159 citations

Epstein-Barr virus shuttle vector for stable episomal replication of cDNA expression libraries in human cells.

1988 • 154 citations

Stable transformation of mouse L cells for human membrane T-cell differentiation antigens, HLA and beta 2-microglobulin: selection by fluorescence-activated cell sorting.

1983 • 153 citations

The MHC-Binding and gp120-Binding Functions of CD4 Are Separable

1989 • 151 citations

UC 729-6, a human lymphoblastoid B-cell line useful for generating antibody-secreting human-human hybridomas.

1983 • 149 citations

Species-restricted interactions between CD8 and the alpha 3 domain of class I influence the magnitude of the xenogeneic response.

1989 • 147 citations

Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

1989 • 140 citations

Activated CD8 binding to class I protein mediated by the T-cell receptor results in signalling

1990 • 136 citations

Direct evidence for binding of CD8 to HLA class I antigens.

1989 • 103 citations

Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to its human counterpart, Leu-2/T8, and to immunoglobulin variable regions.

1985 • 101 citations

The Immunoglobulin Superfamily: Domains For Cell Surface Recognition

1988 • 94 citations

Biosynthesis and surface expression of T8 by peripheral blood T4+ cells in vitro.

1986 • 92 citations

The Lyt-2 molecule recognizes residues in the class I alpha 3 domain in allogeneic cytotoxic T cell responses.

1988 • 88 citations

Strong xenogeneic HLA response in transgenic mice after introducing an α3 domain into HLA B27

1990 • 88 citations

CD8 is required during positive selection of CD4-/CD8+ T cells.

1990 • 65 citations

Epstein-Barr Virus Shuttle Vector for Stable Episomal Replication of cDNA Expression Libraries in Human Cells

1988 • 45 citations

Formal proof that different-size Lyt-2 polypeptides arise from differential splicing and post-transcriptional regulation.

1986 • 41 citations

Altered structure of HLA class I heavy chains associated with mouse beta-2 microglobulin

1985 • 33 citations

The alpha-chain of murine CD8 lacks an invariant Ig-like disulfide bond but contains a unique intrachain loop instead.

1989 • 22 citations

Elimination of CD8+ thymocytes in transgenic mice expressing an anti-Lyt2.2 immunoglobulin heavy chain gene.

1989 • 22 citations