Copolymer 1 inhibits chronic relapsing experimental allergic encephalomyelitis induced by proteolipid protein (PLP) peptides in mice and interferes with PLP-specific T cell responses

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

Superantigens and Their Potential Role in Human Disease

1993 • 620 citations

Automated Synthesis of Peptides

1965 • 516 citations

A Pilot Trial of Cop 1 in Exacerbating–Remitting Multiple Sclerosis

1987 • 465 citations

Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide

1971 • 431 citations

Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

1989 • 372 citations

Direct binding of myelin basic protein and synthetic copolymer 1 to class II major histocompatibility complex molecules on living antigen-presenting cells--specificity and promiscuity.

1994 • 243 citations

Relapsing experimental allergic encephalomyelitis in the SJL/J mouse.

1981 • 197 citations

Myelin proteolipid protein-induced experimental allergic encephalomyelitis. Variations of disease expression in different strains of mice.

1988 • 172 citations

Chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in PL/J mice by myelin oligodendrocyte glycoprotein (MOG)‐derived peptide: Preliminary analysis of MOG T cell epitopes

1995 • 157 citations

Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides.

1990 • 140 citations

Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice.

1992 • 134 citations

Suppression of experimental allergic encephalomyelitis in rhesus monkeys by a synthetic basic copolymer

1974 • 127 citations

A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis.

1988 • 126 citations

Suppression by several synthetic polypeptides of experimental allergic encephalomyelitis induced in guinea pigs and rabbits with bovine and human basic encephalitogen

1973 • 123 citations

Degenerate binding of immunogenic peptides to HLA-DR proteins on B cell Srfaces

1990 • 122 citations

Inhibition of experimental autoimmune encephalomyelitis induction in SJL/J mice by using a peptide with high affinity for IAs molecules.

1990 • 118 citations

Effect of Cyclophosphamide on Suppressor Cell Activity in Mice Unresponsive to EAE

1979 • 117 citations

Specific inhibition of the T-cell response to myelin basic protein by the synthetic copolymer Cop 1.

1988 • 115 citations

Synthetic copolymer 1 inhibits human T-cell lines specific for myelin basic protein.

1992 • 111 citations

In vivo and in vitro immunological cross‐reactions between basic encephalitogen and synthetic basic polypeptides capable of suppressing experimental allergic encephalomyelitis

1973 • 103 citations

Peptide competition for antigen presentation

1990 • 101 citations

Multiple sclerosis: an autoimmune disease of multifactorial etiology

1992 • 95 citations

T suppressor hybridomas and interleukin‐2‐dependent lines induced by copolymer 1 or by spinal cord homogenate down‐regulate experimental allergic encephalomyelitis

1993 • 88 citations

Cross-reactions and specificities of monoclonal antibodies against myelin basic protein and against the synthetic copolymer 1.

1991 • 82 citations

Copolymer-1-induced inhibition of antigen-specific T cell activation: interference with antigen presentation

1992 • 81 citations

Experimental allergic encephalomyelitis induced by proteolipid apoprotein in Lewis rats

1986 • 78 citations

Chronic experimental allergic encephalomyelitis produced by bovine proteolipid apoprotein: Immunological studies in rabbits

1983 • 76 citations

Chronic experimental allergic encephalomyelitis in guinea pigs induced by proteolipid protein

1985 • 75 citations

Location of a new encephalitogenic epitope (residues 43 to 64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL x PL)F1 mice.

1991 • 72 citations

DM-20, a proteolipid apoprotein, is an encephalitogen of acute and relapsing autoimmune encephalomyelitis in mice.

1986 • 67 citations

Molecular requirements involved in suppression of eae by synthetic basic copolymers of amino acids

1976 • 66 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. V. Hierarchy of suppression by myelin basic protein from different species

1992 • 63 citations

Minireview: Autoimmune responses to myelin proteolipid protein

1994 • 59 citations

The effect of Cop 1, a synthetic polypeptide, on chronic relapsing experimental allergic encephalomyelitis in guinea pigs

1979 • 59 citations

Myelin proteolipid protein: minimum sequence requirements for active induction of autoimmune encephalomyelitis in SWR/J and SJL/J mice

1992 • 58 citations

Direct binding of a myasthenia gravis related epitope to MHC class II molecules on living murine antigen-presenting cells.

1989 • 48 citations

Susceptibility to Proteolipid Apoprotein and Its Encephalitogenic Determinants in Mice

1990 • 29 citations

Superantigens

1992 • 21 citations

Chronic experimental allergic encephalomyelitis and antibody responses in rabbits immunized with bovine proteolipid apoprotein

1986 • 17 citations

Direct binding of a synthetic multichain polypeptide to class II major histocompatibility complex molecules on antigen-presenting cells and stimulation of a specific T-cell line require processing of the polypeptide.

1991 • 15 citations

Suppressive activity of Cop 1 in EAE and its relevance to multiple sclerosis.

1990 • 14 citations

A peptide binding weakly to the major histocompatibility molecule augments T cell responses

1994 • 9 citations