Anti-graft-versus-host disease effect of DT390-anti-CD3sFv, a single- chain Fv fusion immunotoxin specifically targeting the CD3 epsilon moiety of the T-cell receptor

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

1981 • 14,396 citations

Evaluation of survival data and two new rank order statistics arising in its consideration.

1966 • 7,595 citations

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

1989 • 3,067 citations

Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-Sepharose

1978 • 2,726 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.

1979 • 1,301 citations

The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.

1987 • 1,153 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views.

1980 • 574 citations

Human T cell antigens defined by monoclonal antibodies: the 65,000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin.

1980 • 429 citations

ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products.

1980 • 323 citations

Mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes.

1986 • 249 citations

In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice

1994 • 245 citations

Graft-versus-Host-Reactions: A Review

1976 • 227 citations

T CELL SUBSETS AND GRAFT-VERSUS-HOST DISEASE

1987 • 223 citations

Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host disease

1991 • 180 citations

Mutations in Diphtheria Toxin Separate Binding from Entry and Amplify Immunotoxin Selectivity

1987 • 173 citations

Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor

1995 • 148 citations

ANTI-CD3 F(abʼ)2 FRAGMENTS ARE IMMUNOSUPPRESSIVE IN VIVO WITHOUT EVOKING EITHER THE STRONG HUMORAL RESPONSE OR MORBIDITY ASSOCIATED WITH WHOLE mAb

1990 • 124 citations

Ricin A-Chain and Ricin A-Chain Immunotoxins Rapidly Damage Human Endothelial Cells: Implications for Vascular Leak Syndrome

1993 • 106 citations

Use of an anti-pan T-lymphocyte ricin a chain immunotoxin in steroid- resistant acute graft-versus-host disease

1990 • 105 citations

T CELL DEPLETION FOR GRAFT-VERSUS-HOST-DISEASE PROPHYLAXIS

1989 • 98 citations

Attenuation of graft-versus-host disease and graft rejection by ex vivo immunotoxin elimination of alloreactive T cells in an H-2 haplotype disparate mouse combination

1994 • 85 citations

Evaluation of ricin A-chain immunotoxins directed against human T cells

1986 • 85 citations

Characterization of alloimmunization-induced T lymphocytes reactive against AKR leukemia in vitro and correlation with graft-vs-leukemia activity in vivo.

1983 • 83 citations

Cloned fragment of diphtheria toxin linked to T cell-specific antibody identifies regions of B chain active in cell entry.

1986 • 76 citations

Combined ex vivo treatment with immunotoxins and mafosfamid: a novel immunochemotherapeutic approach for elimination of neoplastic T cells from autologous marrow grafts.

1985 • 69 citations

Bone marrow transplantation across major histocompatibility barriers. V. Protection of mice from lethal graft-vs.-host disease by pretreatment of donor cells with monoclonal anti-Thy-1.2 coupled to the toxin ricin.

1982 • 69 citations

Phase I trial of an interleukin-2 fusion toxin (DAB486IL-2) in hematologic malignancies: Complete response in a patient with Hodgkin's disease refractory to chemotherapy

1994 • 59 citations

Lethal murine graft-versus-host disease induced by donor gamma/delta expressing T cells with specificity for host nonclassical major histocompatibility complex class Ib antigens

1996 • 59 citations

Mammalian expression and secretion of functional single-chain Fv molecules

1994 • 58 citations

A TCR Cell Recognizing a Novel TL-encoded Gene Product

1989 • 50 citations

Preparation and characterization of a disulfide-stabilized Fv fragment of the anti-Tac antibody: Comparison with its single-chain analog

1995 • 48 citations

Potentiation of granulocyte colony-stimulating factor-induced mobilization of circulating progenitor cells by seven-day pretreatment with interleukin-3

1996 • 48 citations

Successful treatment of human acute T-cell leukemia in SCID mice using the anti-CD7-deglycosylated ricin A-chain immunotoxin DA7.

1992 • 48 citations

An Anti-CD3 Single-chain Immunotoxin with a Truncated Diphtheria Toxin Avoids Inhibition by Pre-existing Antibodies in Human Blood

1995 • 46 citations

In vivo administration of anti-CD3 monoclonal antibodies or immunotoxins in murine recipients of allogeneic T cell-depleted marrow for the promotion of engraftment.

1991 • 45 citations

Phase I Trial of the Diphtheria Toxin/Interleukin-2 Fusion Protein DAB₄₈₆IL-2: Efficacy in Mycosis Fungoides and Other Non-Hodgkin's Lymphomas

1993 • 36 citations

Immunotoxins: will their clinical promise be fulfilled? [editorial]

1994 • 36 citations

Administration of disulfide‐stabilized Fv‐immunotoxins B1(dsFv)‐PE38 and B3(dsFv)‐PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice

1995 • 35 citations

Selective abrogation of antigen-specific human B cell responses by antigen-ricin conjugates.

1982 • 32 citations

Interleukin-1 or tumor necrosis factor-alpha antagonists do not inhibit graft-versus-host disease induced across the major histocompatibility barrier in mice.

1995 • 31 citations

Reactivity of murine cytokine fusion toxin, diphtheria toxin390-murine interleukin-3 (DT390-mIL-3), with bone marrow progenitor cells

1996 • 29 citations

A large proportion of T lymphocytes lack CD5 expression after bone marrow transplantation

1989 • 28 citations

Combination graft-versus-host disease prophylaxis using immunotoxin (anti-CD5-RTA [Xomazyme-CD5]) plus methotrexate and cyclosporine or prednisone after unrelated donor marrow transplantation.

1993 • 24 citations

Structure—activity relationships in diphtheria toxin and Pseudomonas aeruginosa exotoxin A

1988 • 23 citations

Toxicity and efficacy of anti-T-cell ricin toxin A chain immunotoxins in a murine model of established graft-versus-host disease induced across the major histocompatibility barrier

1991 • 23 citations

A large proportion of T lymphocytes lack CD5 expression after bone marrow transplantation

1989 • 22 citations

Cytotoxicity of recombinant Fab and Fv immunotoxins on adult T-cell leukemia lymph node and blood cells in the presence of soluble interleukin-2 receptor.

1994 • 20 citations

Human T Lymphocyte Differentiation Antigens as Target for Immunotoxins or Complement‐Mediated Cytotoxicity

1988 • 20 citations

Phase I Trial of a Genetically Engineered Interleukin-2 Fusion Toxin (DAB₄₈₆IL-2) as a 6 Hour Intravenous Infusion in Patients with Hematologic Malignancies

1994 • 20 citations

Toxicity and efficacy of anti-T-cell ricin toxin A chain immunotoxins in a murine model of established graft-versus-host disease induced across the major histocompatibility barrier

1991 • 14 citations

Therapy for ongoing graft-versus-host disease induced across the major or minor histocompatibility barrier in mice with anti-CD3F(ab')2-ricin toxin A chain immunotoxin

1995 • 13 citations

Anti-pan T lymphocyte ricin A chain immunotoxin (H65-RTA) and methylprednisolone for acute GVHD prophylaxis following allogeneic BMT from HLA-identical sibling donors.

1993 • 12 citations

Insertion of constant region domains of human IgG, into CD4-PE40 increases its plasma half-life

1993 • 12 citations

Targeting T cells for GVHD therapy

1996 • 7 citations

Attenuation of graft-versus-host disease and graft rejection by ex vivo immunotoxin elimination of alloreactive T cells in an H-2 haplotype disparate mouse combination

1994 • 5 citations