Monoclonal antibodies to human tumor necrosis factor α: In vitro and in vivo application

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Selected methods in cellular immunology

1981 • 1,915 citations

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

1984 • 1,738 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASE

1987 • 1,108 citations

Human tumor necrosis factor. Production, purification, and characterization.

1985 • 922 citations

BONE-MARROW TRANSPLANTATION IN A PATIENT WITH THE WISKOTT-ALDRICH SYNDROME

1968 • 873 citations

Tumor Necrosis Factor (Cachectin) as an Essential Mediator in Murine Cerebral Malaria

1987 • 749 citations

Immunoglobulin producing hybrid cell lines

1980 • 620 citations

Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease.

1987 • 609 citations

Structure of tumour necrosis factor

1989 • 512 citations

RAISED SERUM LEVELS OF TUMOUR NECROSIS FACTOR IN PARASITIC INFECTIONS

1986 • 469 citations

The active form of tumor necrosis factor is a trimer.

1987 • 430 citations

Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes.

1987 • 372 citations

Antitumor activity of murine tumor necrosis factor (TNF) against transplanted murine tumors and heterotransplanted human tumors in nude mice

1984 • 313 citations

Raised serum levels of cachectin/tumor necrosis factor alpha in renal allograft rejection.

1987 • 206 citations

Weight loss associated with an endotoxin-induced mediator from peritoneal macrophages: The role of cachectin (tumor necrosis factor)

1985 • 205 citations

Polypetide mediator network

1987 • 200 citations

Tumor necrosis factor is an important mediator of tumor cell killing by human monocytes.

1987 • 192 citations

Mechanisms that regulate the production and effects of tumor necrosis factor-alpha.

1989 • 115 citations

Recombinant human tumor necrosis factor‐α: Thrombus formation is a cause of anti‐tumor activity

1988 • 110 citations

Tumor necrosis factor as effector molecule in monocyte mediated cytotoxicity.

1986 • 89 citations

Lipopolysaccharide (LPS) stimulates fresh human monocytes to lyse actinomycin D-treated WEHI-164 target cells via increased secretion of a monokine similar to tumor necrosis factor.

1985 • 79 citations

Preparation and Characterization of Monoclonal Antibodies Directed Against Antigenic Determinants of Recombinant Human Tumour Necrosis Factor (rTNF)

1987 • 63 citations

Monoclonal Antibodies to Human Tumor Necrosis Factors Alpha and Beta: Application for Affinity Purification, Immunoassays, and as Structural Probes

1987 • 63 citations

T Cell‐Mediated Production of Tumour Necrosis Factor‐α by Monocytes

1988 • 31 citations

Production and characterization of monoclonal antibodies against recombinant human tumor necrosis factor/cachectin

1986 • 25 citations

Monoclonal antibodies against human recombinant tumor necrosis factor: prevention of endotoxic shock

1988 • 25 citations

Production and characterization of monoclonal antibodies to human tumor necrosis factor

1987 • 22 citations

Murine Monoclonal Antibodies Defining Neutralizing Epitopes on Tumor Necrosis Factor

1987 • 17 citations