Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease.

The Fas Death Factor

1995 • 4,070 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASE

1987 • 1,108 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Tumor Necrosis Factor (Cachectin) as an Essential Mediator in Murine Cerebral Malaria

1987 • 749 citations

Tumor necrosis factor Characterization at the molecular, cellular and in vivo level

1991 • 708 citations

Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease.

1987 • 609 citations

The CTL's kiss of death

1995 • 504 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.

1993 • 410 citations

The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster

1994 • 335 citations

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

1994 • 307 citations

A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice.

1984 • 302 citations

NK-lysin, a novel effector peptide of cytotoxic T and NK cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, antibacterial and antitumour activity.

1995 • 279 citations

The Ligands and Receptors of the Lymphotoxin System

1995 • 262 citations

Graft-vs.-Host Disease

1997 • 262 citations

Cytokine dysregulation as a mechanism of graft versus host disease

1993 • 229 citations

Graft-versus-Host-Reactions: A Review

1976 • 227 citations

A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.

1994 • 224 citations

Biology and Genetics of Hybrid Resistance

1987 • 191 citations

Perforin and Granzymes: Crucial Effector Molecules in Cytolytic T Lymphocyte and Natural Killer Cell-Mediated Cytotoxicity

1995 • 153 citations

Massive upregulation of the Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndrome.

1995 • 130 citations

Graft-versus-host disease: new directions for a persistent problem

1994 • 122 citations

Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders.

1995 • 117 citations

Phosphorylcholine acts as a Ca2+-dependent receptor molecule for lymphocyte perforin

1989 • 114 citations

Association of lpr gene with graft-vs.-host disease-like syndrome.

1985 • 112 citations

Acute rejection of vascular heart allografts by perforin‐deficient mice

1995 • 99 citations

Direct and indirect mechanisms mediating apoptosis during HIV infection: contribution to in vivo CD4 T cell depletion

1993 • 91 citations

Graft‐versus‐Host Reactions and Disease

1985 • 82 citations

Mutations in the Fas antigen gene in lpr mice

1994 • 61 citations

Evidence for differentiation of NK1+ cells into cytotoxic T cells during acute rejection of allogeneic bone marrow grafts

1990 • 12 citations