Prevention of Collagen-Induced Arthritis with an Antibody to gp39, the Ligand for CD40

Autoimmunity to type II collagen an experimental model of arthritis.

1977 • 1,599 citations

Immunisation against heterologous type II collagen induces arthritis in mice

1980 • 1,025 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

1993 • 836 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.

1992 • 818 citations

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

1993 • 739 citations

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

1993 • 719 citations

Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion.

1992 • 409 citations

Identification of a novel surface protein on activated CD4+ T cells that induces contact-dependent B cell differentiation (help).

1992 • 357 citations

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39.

1993 • 354 citations

CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation

1992 • 327 citations

Regulation of Human B-Cell Activation and Adhesion

1991 • 161 citations

The role of class II molecules in human B cell activation. Association with phosphatidyl inositol turnover, protein tyrosine phosphorylation, and proliferation.

1990 • 156 citations

Experimental arthritis in a nonhuman primate. I. Induction by bovine type II collagen.

1986 • 139 citations

Anti‐CD4 Monoclonal Antibodies in Therapy: Creation of Nonclassical Tolerance in the Adult

1992 • 104 citations

Acceleration of onset of collagen-induced arthritis by intra-articular injection of tumour necrosis factor or transforming growth factor-beta

1992 • 103 citations

Role of T lymphocytes in murine collagen induced arthritis

1986 • 62 citations

Collagen-induced arthritis in rats. Examination of the epitope specificities of circulating and cartilage-bound antibodies produced by outbred and inbred rats using cyanogen bromide-derived peptides purified from heterologous and homologous type II collagens.

1992 • 21 citations

Type II collagen-induced murine arthritis: induction of arthritis depends on antigen-presenting cell function as well as susceptibility of host to an anticollagen immune response.

1992 • 17 citations