Phase I trial of an interleukin-2 (IL-2) fusion toxin (DAB486IL-2) in hematologic malignancies expressing the IL-2 receptor

Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro.

1985 • 1,143 citations

T cell growth factor receptors. Quantitation, specificity, and biological relevance

1981 • 1,087 citations

Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen.

1984 • 742 citations

Novel Interleukin-2 Receptor Subunit Detected by Cross-Linking Under High-Affinity Conditions

1986 • 585 citations

Interleukin 2 high-affinity receptor expression requires two distinct binding proteins.

1987 • 565 citations

Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex.

1986 • 477 citations

The Structure, Function, and Expression of Interleukin-2 Receptors on Normal and Malignant Lymphocytes

1986 • 460 citations

Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia.

1983 • 385 citations

Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus.

1983 • 354 citations

A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors

1987 • 306 citations

Interleukin 2 binding molecule distinct from the Tac protein: analysis of its role in formation of high-affinity receptors.

1987 • 252 citations

Interleukin-2 receptor (Tac antigen) expressed on adult T cell leukemia cells.

1985 • 237 citations

Diphtheria toxin receptor binding domain substitution with interleukin-2: genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein

1987 • 236 citations

Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein.

1988 • 220 citations

Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes

1985 • 193 citations

Expression of functional IL 2 receptors by lipopolysaccharide and interferon-gamma stimulated human monocytes.

1987 • 176 citations

Only high-affinity receptors for interleukin 2 mediate internalization of ligand.

1986 • 174 citations

Phase I trial of H65-RTA immunoconjugate in patients with cutaneous T- cell lymphoma

1991 • 118 citations

Interleukin 2 receptor‐targeted cytotoxicity. Receptor binding requirements for entry of a diphtheria toxin‐related interleukin 2 fusion protein into cells

1990 • 117 citations

High serum levels of soluble interleukin 2 receptor in patients with B chronic lymphocytic leukemia

1987 • 117 citations

Immunological characterization of homosexual males.

1983 • 108 citations

Distribution of lymphocytes with interleukin-2 receptors (TAC antigens) in reactive lymphoproliferative processes, Hodgkin's disease, and non-Hodgkin's lymphomas. An immunohistologic study of 300 cases.

1987 • 85 citations

IL-2 receptor expression in human lymphoid lesions. Immunohistochemical study of 166 cases.

1987 • 83 citations

Serum soluble IL-2 receptor as a tumor marker in patients with hairy cell leukemia

1988 • 82 citations

Expression of interleukin-2 receptor beta subunit in hematopoietic malignancies

1989 • 72 citations

Elevated Serum Levels of Soluble Tac Peptide in Adult T-Cell Leukemia: Correlation with Clinical Status during Chemotherapy

1988 • 64 citations

Monoclonal antibody analysis of diphtheria toxin—I. Localization of epitopes and neutralization of cytotoxicity

1984 • 52 citations

Heterogeneity in response to interleukin 2 and interleukin 2-producing ability of adult T cell leukemic cells.

1987 • 46 citations

Interleukin 2 receptor (Tac antigen) expression in HTLV-I-associated adult T-cell leukemia.

1985 • 46 citations

The malignant B cells from B-chronic lymphocytic leukemia patients release TAC-soluble interleukin-2 receptors

1988 • 46 citations

Elevated serum-soluble interleukin-2 receptor (Tac antigen) levels in chronic myelogenous leukemia patients with blastic crisis

1989 • 42 citations

The malignant B cells from B-chronic lymphocytic leukemia patients release TAC-soluble interleukin-2 receptors

1988 • 39 citations

Demonstration of high-affinity interleukin-2 receptors on B-chronic lymphocytic leukemia cells: Functional and structural characterization

1990 • 37 citations

Acute lymphoblastic leukemia and non-Hodgkin's lymphoma of T lineage: colony-forming cells retain growth factor (interleukin 2) dependence

1986 • 36 citations

Serum levels of soluble interleukin‐2 receptor in hairy cell leukaemia: a reliable marker of neoplastic bulk

1989 • 31 citations

Induction of Tac antigen and proliferation of myeloid leukemic cells by ATL-derived factor: comparison with other agents that promote differentiation of human myeloid or monocytic leukemic cells

1986 • 29 citations

Intracellular pathway of interleukin 2 following receptor‐mediated endocytosis

1986 • 29 citations

Elevated serum levels of soluble interleukin-2 receptors in HTLV-I--associated myelopathy.

1989 • 26 citations

Clinical analysis of 33 patients with adult T‐cell leukemia (ATL)‐diagnostic criteria and significance of high‐ and low‐risk ATL

1986 • 25 citations

Lymphocyte populations and TAC-antigen in diffuse B-cell lymphomas

1986 • 23 citations

Determination of Corynebacterium diphtheriae toxigenicity by a colorimetric tissue culture assay

1978 • 21 citations

Pharmacokinetics of the recombinant fusion protein DAB486IL-2 in animal models

1990 • 18 citations

Evaluation of serum levels of soluble interleukin-2 receptor in patients with chronic lymphoproliferative disorders of T-lymphocytes

1989 • 17 citations

Serum soluble IL-2 receptor as a tumor marker in patients with hairy cell leukemia

1988 • 11 citations

High serum levels of soluble interleukin 2 receptor in patients with B chronic lymphocytic leukemia

1987 • 8 citations

Phase I trial of H65-RTA immunoconjugate in patients with cutaneous T- cell lymphoma

1991 • 7 citations

RELATIONSHIP OF EXPOSURE TO HUMAN T LYMPHOTROPIC VIRUS AND T HELPER CELLS IN HOMOSEXUAL MEN

1986 • 4 citations

Acute lymphoblastic leukemia and non-Hodgkin's lymphoma of T lineage: colony-forming cells retain growth factor (interleukin 2) dependence

1986 • 3 citations

Elevated serum-soluble interleukin-2 receptor (Tac antigen) levels in chronic myelogenous leukemia patients with blastic crisis

1989 • 2 citations