Genetic alterations in breast cancer

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors

1992 • 3,344 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

1990 • 2,505 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Localization of a Breast Cancer Susceptibility Gene, BRCA2 , to Chromosome 13q12-13

1994 • 1,884 citations

Risks of cancer in BRCA1-mutation carriers

1994 • 1,865 citations

Mutations of the VHL tumour suppressor gene in renal carcinoma

1994 • 1,719 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

A novel cyclin encoded by a bcl1-linked candidate oncogene

1991 • 1,286 citations

Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

1993 • 1,269 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

BRCA1 Mutations in Primary Breast and Ovarian Carcinomas

1994 • 1,205 citations

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1994 • 982 citations

c-erbB-2 Expression and Response to Adjuvant Therapy in Women with Node-Positive Early Breast Cancer

1994 • 981 citations

Identification of Heregulin, a Specific Activator of p185 ^erbB2

1992 • 963 citations

Maspin, a Serpin with Tumor-Suppressing Activity in Human Mammary Epithelial Cells

1994 • 913 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

Neu-Protein Overexpression in Breast Cancer

1988 • 860 citations

Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) Breast Cancer Study Group.

1992 • 855 citations

Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

1995 • 824 citations

Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history.

1993 • 796 citations

Antioncogenes and human cancer.

1993 • 772 citations

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1992 • 757 citations

Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization.

1994 • 748 citations

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.

1989 • 742 citations

Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining.

1994 • 673 citations

Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis.

1993 • 658 citations

Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families

1994 • 626 citations

Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas.

1989 • 598 citations

Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

1995 • 585 citations

HER-2/neu oncogene protein and prognosis in breast cancer.

1989 • 579 citations

Mammographically detected duct carcinoma in situ. Frequency of local recurrence following tylectomy and prognostic effect of nuclear grade on local recurrence

1989 • 563 citations

Microsatellite instability: marker of a mutator phenotype in cancer.

1994 • 552 citations

ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization.

1992 • 542 citations

Isolation of the NeuHER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells

1992 • 534 citations

Human c- myc Transcription Factor PuF Identified as nm23-H2 Nucleoside Diphosphate Kinase, a Candidate Suppressor of Tumor Metastasis

1993 • 504 citations

Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells.

1994 • 481 citations

Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families

1994 • 479 citations

How many mutations are required for tumorigenesis? implications from human cancer data

1993 • 466 citations

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

1993 • 445 citations

Overexpression of HER-2/neu and its relationship with other prognostic factors change during the progression of in situ to invasive breast cancer

1992 • 415 citations

Allele losses in the region 17q12–21 in familial breast and ovarian cancer involve the wild–type chromosome

1992 • 414 citations

Instability of short tandem repeats (microsatellites) in human cancers

1994 • 413 citations

Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas.

1986 • 413 citations

Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential.

1989 • 398 citations

Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer

1994 • 389 citations

Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis.

1987 • 360 citations

Cyclin E, a Potential Prognostic Marker in Breast Cancer.

1997 • 346 citations

Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene.

1987 • 335 citations

Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families

1994 • 334 citations

Tumorigenicity in Human Melanoma Cell Lines Controlled by Introduction of Human Chromosome 6

1990 • 333 citations

Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer

1994 • 329 citations

Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas.

1992 • 322 citations

Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: effects on tumor metastatic potential, colonization and enzymatic activity.

1993 • 298 citations

An Association between the Risk of Cancer and Mutations in the HRAS1 Minisatellite Locus

1993 • 290 citations

Detection of breast cancer micrometastases in axillary lymph nodes by using polymerase chain reaction.

1994 • 271 citations

A germline mutation in the androgen receptor gene in two brothers with breast cancer and Reifenstein syndrome

1992 • 251 citations

Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors.

1992 • 251 citations

Evaluating the Potential Usefulness of New Prognostic and Predictive Indicators on Node-Negative Breast Cancer Patients

1993 • 250 citations

Genetic alterations in bladder cancer

1993 • 243 citations

BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers.

1991 • 238 citations

Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13.

1995 • 236 citations

Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types

1994 • 228 citations

Characterization of chromosomal anomalies in human breast cancer

1990 • 218 citations

Oncogenic conversion by regulatory changes in transcription factors

1991 • 215 citations

c-myc amplification is a better prognostic factor than HER2/neu amplification in primary breast cancer.

1992 • 212 citations

Catalog of Chromosome Aberrations in Cancer

1996 • 204 citations

Chromosome analysis of 97 primary breast carcinomas: Identification of eight karyotypic subgroups

1995 • 203 citations

The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours.

1989 • 202 citations

At least four different chromosomal regions are involved in loss of heterozygosity in human breast carcinoma

1989 • 198 citations

Amplification of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer.

1992 • 194 citations

ERBB2 amplification in breast cancer with a high rate of proliferation.

1991 • 191 citations

Microsatellite instability and loss of heterozygosity in breast cancer.

1994 • 189 citations

Increased copy number at 20q13 in breast cancer: defining the critical region and exclusion of candidate genes.

1994 • 187 citations

The neu-oncogene: signal transduction pathways, transformation mechanisms and evolving therapies.

1994 • 186 citations

Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or 18

1991 • 184 citations

Tumor Cell Growth Arrest Caused by Subchromosomal Transferable DNA Fragments from Chromosome 11

1993 • 177 citations

Amplification of the int-2 gene in primary human breast tumors.

1988 • 172 citations

Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer

1992 • 168 citations

Stability of HER-2/neu Expression Over Time and at Multiple Metastatic Sites

1993 • 161 citations

Prognostic value of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitors PAI-1 and PAI-2 in breast carcinomas

1994 • 159 citations

p53 mutations occur in aggressive breast cancer.

1992 • 159 citations

Familial male breast cancer is not linked to the BRCA1 locus on chromosome 17q

1994 • 158 citations

A Novel Function for the nm23-H1 Gene: Overexpression in Human Breast Carcinoma Cells Leads to the Formation of Basement Membrane and Growth Arrest

1994 • 157 citations

Water-soluble vitamin K in the newborn.

1949 • 156 citations

Proto-oncogene amplification and human breast tumor phenotype

1990 • 154 citations

p53 allele losses, mutations and expression in breast cancer and their relationship to clinico‐pathological parameters

1992 • 152 citations

Overexpression of either c-myc or c-erbB-2/neu proto-oncogenes in human breast carcinomas: correlation with poor prognosis.

1988 • 149 citations

Identification of cryptic sites of DNA sequence amplification in human breast cancer by chromosome microdissection

1994 • 142 citations

Definition of a tumor suppressor locus within human chromosome 3p21-p22.

1992 • 142 citations

Heterogeneity for Allelic Loss in Human Breast Cancer

1992 • 135 citations

Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4.

1993 • 132 citations

Suppression of tumorigenicity of breast cancer cells by microcell-mediated chromosome transfer: studies on chromosomes 6 and 11.

1994 • 132 citations

Loss of heterozygosity and linkage analysis in breast carcinoma: indication for a putative third susceptibility gene on the short arm of chromosome 8.

1995 • 132 citations

Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1.

1994 • 125 citations

Loss of heterozygosity and p53 gene mutations in breast cancer.

1994 • 124 citations

Detection of DNA amplification in 17 primary breast carcinomas with homogeneously staining regions by a modified comparative genomic hybridization technique

1994 • 124 citations

Loss of heterozygosity on chromosomes 17 and 18 in breast carcinoma: two additional regions identified.

1990 • 123 citations

(C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer.

1994 • 120 citations

Nm23 Protein Expression in Ductal In Situ and Invasive Human Breast Carcinoma

1993 • 119 citations

Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma

1994 • 116 citations

Topoisomerase II alpha co-amplification with erbB2 in human primary breast cancer and breast cancer cell lines: relationship to m-AMSA and mitoxantrone sensitivity.

1993 • 115 citations

The retinoblastoma gene in breast cancer: allele loss is not correlated with loss of gene protein expression.

1992 • 113 citations

Deletion of two separate regions on chromosome 3p in breast cancers.

1994 • 113 citations

Possible linkage of the estrogen receptor gene to breast cancer in a family with late-onset disease.

1991 • 112 citations

Mutational analysis of CDKN2 (MTS1/p16ink4) in human breast carcinomas.

1994 • 107 citations

Deletion of chromosome 17p loci in breast cancer cells detected by fluorescence in situ hybridization.

1992 • 106 citations

c‐myc amplification is an independent prognostic factor in postmenopausal breast cancer

1992 • 106 citations

Ductal carcinoma in-situ of the breast; second EORTC consensus meeting

1992 • 106 citations

Patterns of dna amplification at band q13 of chromosome 11 in human breast cancer

1994 • 101 citations

p53 mutations and histological type of invasive breast carcinoma.

1993 • 100 citations

Correlation of loss of alleles on the short arms of chromosomes 11 and 17 with metastasis of primary breast cancer to lymph nodes.

1992 • 100 citations

A genetic model of melanoma tumorigenesis based on allelic losses

1995 • 99 citations

Cytogenetic studies on human breast carcinomas

1986 • 99 citations

Lack of evidence for the prognostic significance of c-erbB-2 amplification in human breast carcinoma.

1988 • 97 citations

Tumor suppressor activity of RB and p53 genes in human breast carcinoma cells.

1993 • 97 citations

Improved technique for short‐term culture and cytogenetic analysis of human breast cancer

1992 • 97 citations

A novel metalloprotease/disintegrin–like gene at 17q21.3 is somatically rearranged in two primary breast cancers

1993 • 97 citations

Chromosome abnormalities in benign hyperproliferative disorders of epithelial and stromal breast tissue

1995 • 92 citations

Evidence for a gene on 17p13.3, distal to TP53, as a target for allele loss in breast tumors without p53 mutations.

1994 • 91 citations

Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer

1993 • 91 citations

Clonal chromosome abnormalities in human breast carcinomas I. Twenty‐eight cases with primary disease

1993 • 89 citations

Location of genes involved in invasion and metastasis on human chromosome 7.

1987 • 85 citations

Relationship of c-myc Amplification to Progression of Breast Cancer From In Situ to Invasive Tumor and Lymph Node Metastasis

1993 • 84 citations

A 3‐Mb physical map of the chromosome region 8p21.3‐p22, including a 600‐kb region commonly deleted in human hepatocellular carcinoma, colorectal cancer, and non‐small cell lung cancer

1994 • 84 citations

Genetic changes in epithelial solid neoplasia.

1994 • 84 citations

Differential suppression of mammary and prostate cancer metastasis by human chromosomes 17 and 11.

1994 • 83 citations

Identification of human DAN gene, mapping to the putative neuroblastoma tumor suppressor locus.

1994 • 83 citations

Trisomy 7 and trisomy 10 characterize subpopulations of tumor-infiltrating lymphocytes in kidney tumors and in the surrounding kidney tissue.

1992 • 83 citations

Frequent p53 gene mutations and novel alleles in familial breast cancer.

1994 • 83 citations

Clonal chromosome abnormalities in human breast carcinomas II. Thirty‐four cases with metastatic disease

1993 • 79 citations

Genomic alterations in human breast carcinomas

1990 • 79 citations

Suppression of metastasis of rat prostatic cancer by introducing human chromosome 8.

1994 • 79 citations

Evidence for multiple pathways to cellular senescence.

1994 • 78 citations

Suppression of Gene Amplification in Human Cell Hybrids

1992 • 76 citations

Suppression of tumourigenicity in human colon carcinoma cells by introduction of normal chromosome 1p36 region.

1993 • 75 citations

Cytogenetic features of twenty-six primary breast cancers

1991 • 74 citations

Allelic loss on a chromosome 17 in ductal carcinoma in situ of the breast.

1993 • 73 citations

Genetic studies of 457 breast cancers. Clinicopathologic parameters compared with genetic alterations

1994 • 69 citations

Interstitial deletion of the short arm of chromosome 3 as a primary chromosome abnormality in carcinomas of the breast

1993 • 68 citations

Deletions on chromosome 16 in primary familial breast carcinomas are associated with development of distant metastases.

1993 • 68 citations

Transfer of human chromosome 3 to an ovarian carcinoma cell line identifies three regions on 3p involved in ovarian cancer.

1994 • 68 citations

The Human Prohibitin (PHB) Gene Family and Its Somatic Mutations in Human Tumors

1993 • 68 citations

Refinement of regional loss of heterozygosity for chromosome 11p15.5 in human breast tumors.

1993 • 67 citations

Frequent alterations of chromosome 1 in ductal carcinoma in situ of the breast.

1995 • 67 citations

MDM2 gene amplification in human breast cancer

1994 • 66 citations

Novel pattern of p53 gene mutations in an American black cohort with high mortality from breast cancer

1994 • 66 citations

Clonal analysis of predominantly intraductal carcinoma and precancerous lesions of the breast by means of polymerase chain reaction.

1994 • 65 citations

Prognostic factors and response to therapy in breast cancer.

1993 • 61 citations

Two‐color FISH characterization of i(1q) and der(1;16) in human breast cancer cells

1993 • 60 citations

Loss and gain of distinct regions of chromosome 1q in primary breast cancer.

1995 • 60 citations

Allele loss patterns on chromosome 17q in 109 breast carcinomas indicate at least two distinct target regions.

1993 • 58 citations

The insulin‐like growth factor I receptor gene is the target for the 15q26 amplicon in breast cancer

1994 • 56 citations

Pattern of gene alterations in intraductal breast neoplasms associated with histological type and grade.

1995 • 54 citations

Tumor and growth suppression of breast cancer cells by chromosome 17-associated functions.

1994 • 53 citations

Predisposition for breast cancer in carriers of constitutional translocation 11q;22q.

1994 • 52 citations

Molecular genetic analysis of flow-sorted ovarian tumour cells: improved detection of loss of heterozygosity

1994 • 52 citations

Detection of retinoblastoma gene copy number in metaphase chromosomes and interphase nuclei by fluorescence in situ hybridization

1992 • 51 citations

Loss of heterozygosity in familial breast carcinomas.

1993 • 50 citations

Estrogen and progestin effects in human breast carcinogenesis

1993 • 50 citations

Oncogenes and human breast cancer.

1989 • 49 citations

Proto‐oncogene amplification and homogeneously staining regions in human breast carcinomas

1990 • 49 citations

Isolation and characterization of a novel gene with differential expression in benign and malignant human breast tumours

1992 • 48 citations

A tumor suppressor gene on chromosome 1p32-pter controls the amplification of MYC family genes in breast cancer.

1994 • 48 citations

Suggestive evidence for functionally distinct, tumor-suppressor genes on chromosomes 1 and 11 for a human fibrosarcoma cell line, HT1080.

1990 • 47 citations

11q13 Amplification in local recurrence of human primary breast cancer

1995 • 44 citations

A candidate tumor suppressor gene in human breast cancers.

1994 • 44 citations

NME1 Protein Expression and Loss of Heterozygosity Mutations in Primary Human Breast Tumors

1994 • 43 citations

Evidence for limited molecular genetic heterogeneity as defined by allelotyping and clonal analysis in nine metastatic breast carcinomas.

1993 • 43 citations

Fractional allelic imbalance in human breast cancer increases with tetraploidization and chromosome loss

1992 • 42 citations

Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features

1992 • 38 citations

Lack of c-erbB-2 oncoprotein expression in male breast carcinoma.

1991 • 38 citations

Inhibition of tumorigenicity of a murine squamous cell carcinoma (SCC) cell line by a putative tumor suppressor gene on human chromosome 7.

1994 • 35 citations

Amplification of the 11q13 region in human carcinoma cell lines: A mechanistic view

1993 • 33 citations

GST pi gene is frequently coamplified with INT2 and HSTF1 proto-oncogenes in human breast cancers.

1991 • 30 citations

Recurrent homogeneously staining regions in 8p1 in breast cancer and lack of amplification of POLB, LHRH, and PLAT genes

1991 • 30 citations

Loss of heterozygosity on 7q31 occurs early during breast tumorigenesis

1995 • 28 citations

Chromosome anomalies in human breast cancer: evidence for specific involvement of 1q region in lymphocyte cultures.

1991 • 27 citations

Current Issues in Cancer: Genes dreams and cancer

1994 • 26 citations

Intratumoral heterogeneity for amplified genes in human breast carcinoma

1994 • 25 citations

Detailed analysis of loss of heterozygosity on chromosome band 17p13 in breast carcinoma on the basis of a high‐resolution physical map with 29 markers

1994 • 25 citations

Evidence for a gene on 17p13.3, distal to TP53, as a target for allele loss in breast tumors without p53 mutations

1994 • 25 citations

Relationship between loss of estrogen and progesterone receptor expression and of 6q and 11q chromosome arms in breast cancer

1994 • 21 citations

Chronic myelomonocytic leukemia with t(13;14) in a child

1992 • 21 citations

CLONAL CHROMOSOME-ABERRATIONS IN FIBROCYSTIC BREAST DISEASE-ASSOCIATED WITH INCREASED RISK OF CANCER

1994 • 19 citations

Loss of chromosome 3p arm differentiating tumorigenic from non‐tumorigenic cells derived from the same SV40‐transformed human mammary epithelial cells

1995 • 17 citations

Suppression of tumorigenesis by the breast cancer cell line MCF-7 following transfer of a normal human chromosome 11.

1992 • 16 citations

Exclusion of the retinoblastoma gene and chromosome 13q as the site of a primary lesion for human breast cancer.

1990 • 12 citations

Somatic allele loss in genetic linkage analysis of cancer

1994 • 11 citations

The numerical aberrations of chromosome 7 detected by fluorescence in situ hybridization in human breast cancers

1993 • 6 citations

Deleted Work

1955 • 0 citations