Amplification of the 11q13 region in human carcinoma cell lines: A mechanistic view

Enzymatic synthesis of biotin-labeled polynucleotides: novel nucleic acid affinity probes.

1981 • 1,165 citations

Amplification and expression of the c-myc oncogene in human lung cancer cell lines

1983 • 921 citations

Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.

1983 • 764 citations

TP53 tumor suppressor gene: A model for investigating human mutagenesis

1992 • 584 citations

ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization.

1992 • 542 citations

Recent progress in understanding mechanisms of mammalian DNA amplification

1989 • 469 citations

D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1.

1991 • 376 citations

Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas.

1983 • 330 citations

Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas.

1992 • 322 citations

A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration.

1991 • 248 citations

Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications.

1986 • 242 citations

Double minute chromosomes can be produced from precursors derived from a chromosomal deletion.

1988 • 236 citations

The importance of circular DNA in mammalian gene amplification.

1989 • 234 citations

Amplification of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer.

1992 • 194 citations

Co-amplified markers alternate in megabase long chromosomal inverted repeats and cluster independently in interphase nuclei at early steps of mammalian gene amplification.

1992 • 163 citations

Chromosome 11q13 abnormalities in human cancer.

1991 • 160 citations

Characterization of an Episome Produced in Hamster Cells that Amplify a Transfected CAD Gene at High Frequency: Functional Evidence for a Mammalian Replication Origin

1987 • 137 citations

Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules.

1988 • 137 citations

Distinctive chromosomal structures are formed very early in the amplification of CAD genes in Syrian hamster cells

1990 • 136 citations

Early dihydrofolate reductase gene amplification events in CHO cells usually occur on the same chromosome arm as the original locus.

1989 • 132 citations

Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines.

1981 • 127 citations

Analysis of gene amplification in head‐and‐neck squamous‐cell carcinomas

1991 • 126 citations

The multicopy appearance of a large inverted duplication and the sequence at the inversion joint suggest a new model for gene amplification.

1988 • 125 citations

Fusions near telomeres occur very early in the amplification of CAD genes in Syrian hamster cells.

1992 • 108 citations

Structure of an inverted duplication formed as a first step in a gene amplification event: implications for a model of gene amplification.

1987 • 104 citations

Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line.

1989 • 96 citations

Chromosomal destabilization during gene amplification.

1990 • 94 citations

Novel submicroscopic extrachromosomal elements containing amplified genes in human cells

1987 • 85 citations

Double minutes arise from circular extrachromosomal DNA intermediates which integrate into chromosomal sites in human HL-60 leukemia cells.

1990 • 84 citations

Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional evidence for a mammalian replication origin.

1987 • 80 citations

The gene encoding human protective protein (PPGB) is on chromosome 20

1991 • 73 citations

Amplification and enhanced expression of the c-myc oncogene in mouse SEWA tumour cells

1985 • 69 citations

Formation of an inverted duplication can be an initial step in gene amplification.

1988 • 65 citations

Early appearance and long-term persistence of the submicroscopic extrachromosomal elements (amplisomes) containing the amplified DHFR genes in human cell lines.

1990 • 58 citations

Evolution of karyotypic abnormalities and C-MYC oncogene amplification in human colonic carcinoma cell lines

1985 • 54 citations

The role of inverted duplication in the generation of gene amplification in mammalian cells

1991 • 46 citations

Linkage map of a region of human chromosome band 11q13 amplified in breast and squamous cell tumors

1992 • 42 citations

The mammalian dihydrofolate reductase locus

1990 • 37 citations

High c-myc amplification level contributes to the tumorigenic phenotype of the human breast carcinoma cell line SW 613-S.

1988 • 36 citations

11p Deletions and breakpoints in squamous cell carcinoma: Association with altered reactivity with the UM‐E7 antibody

1991 • 36 citations

Excision of N-myc from Chromosome 2 in Human Neuroblastoma Cells Containing Amplified N-myc Sequences

1990 • 36 citations

The evolution of the amplified adenylate deaminase 2 domains in Chinese hamster cells suggests the sequential operation of different mechanisms of DNA amplification

1992 • 35 citations

Fusion and amplification of two originally non‐syntenic chromosomal regions in a mammary carcinoma cell line

1992 • 33 citations

Unstable and stable CAD gene amplification: importance of flanking sequences and nuclear environment in gene amplification.

1987 • 26 citations

Excision of N-myc from chromosome 2 in human neuroblastoma cells containing amplified N-myc sequences.

1990 • 25 citations

Amplification of the N-myc gene in human neuroblastomas: tandemly repeated amplicons within homogeneously staining regions on different chromosomes with the retention of single copy gene at the resident site

1992 • 23 citations

A human sequence homologous to v-sea maps to chromosome 11, band q13.

1988 • 22 citations

The 11q13 amplicon of a mammary carcinoma cell line

1990 • 21 citations

Localization of the HST/FGFK gene with regard to 11 q 13 chromosomal breakpoint and fragile site

1991 • 15 citations

Gene amplification in a human osteosarcoma cell line results in the persistence of the original chromosome and the formation of translocation chromosomes

1992 • 15 citations

Gene amplification in human cells may involve interchromosomal transposition and persistence of the original DNA region.

1992 • 6 citations