Oncogenic conversion by regulatory changes in transcription factors

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

The c-erb-A gene encodes a thyroid hormone receptor

1986 • 1,505 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

The c-erb-A protein is a high-affinity receptor for thyroid hormone

1986 • 1,340 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1990 • 1,272 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities

1988 • 1,084 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

DNA binding activities of three murine Jun proteins: Stimulation by Fos

1988 • 850 citations

Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun

1989 • 698 citations

Leucine Repeats and an Adjacent DNA Binding Domain Mediate the Formation of Functional cFos-cJun Heterodimers

1989 • 676 citations

A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo

1989 • 652 citations

Common DNA binding site for Fos protein complexesand transcription factor AP-1

1988 • 613 citations

Parallel Association of Fos and Jun Leucine Zippers Juxtaposes DNA Binding Domains

1989 • 607 citations

Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist

1989 • 599 citations

The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity.

1989 • 572 citations

The Fos Complex and Fos-Related Antigens Recognize Sequence Elements That Co ntain AP-1 Binding Sites

1988 • 532 citations

Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini

1983 • 532 citations

Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene

1990 • 522 citations

fos-associated cellular p39 is related to nuclear transcription factor AP-1

1988 • 508 citations

jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun

1989 • 488 citations

Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

1987 • 485 citations

The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila

1989 • 472 citations

The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene

1989 • 460 citations

A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity

1991 • 436 citations

Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function

1989 • 431 citations

Delineation of three functional domains of the transcriptional activator encoded by the c-myb protooncogene.

1989 • 342 citations

The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function

1990 • 325 citations

Transcriptional activation by the v-myb oncogene and its cellular progenitor, c-myb

1989 • 302 citations

Nucleic acid sequences of the oncogene v-rel in reticuloendotheliosis virus strain T and its cellular homolog, the proto-oncogene c-rel

1984 • 295 citations

The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation

1989 • 286 citations

v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA

1990 • 236 citations

The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in drosophila

1991 • 229 citations

Biochemical analysis of transcriptional activation by Jun: Differential activity of c- and v-Jun

1989 • 225 citations

Control of c-Jun activity by interaction of a cell-specific inhibitor with regulatory domain δ: Differences between v- and c-Jun

1990 • 212 citations

Trans-repression of the mouse c-fos promoter: A novel mechanism of fos-mediated trans-regulation

1989 • 187 citations

Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences.

1990 • 175 citations

The mouse c-rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain.

1990 • 164 citations

v-erbA specifically suppresses transcription of the avian erythrocyte anion transporter (Band 3) gene

1988 • 153 citations

Mutations in v-myb alter the differentiation of myelomonocytic cells transformed by the oncogene

1990 • 147 citations

v-rel oncoproteins in the nucleus and in the cytoplasm transform chicken spleen cells

1988 • 126 citations

Oncogenic transformation by vrel requires an amino-terminal activation domain.

1990 • 123 citations

Characterization of the hormone-binding domain of the chicken c-erbA/thyroid hormone receptor protein.

1988 • 109 citations

Transactivation of gene expression by nuclear and cytoplasmic rel proteins.

1989 • 100 citations

Phosphorylation of the v-erbA protein is required for its function as an oncogene.

1990 • 83 citations

The viral erbA oncogene protein, a constitutive repressor in animal cells, is a hormone-regulated activator in yeast

1990 • 80 citations

Genetic dissection of functional domains within the avian erythroblastosis virus v-erbA oncogene.

1988 • 28 citations