Pattern of gene alterations in intraductal breast neoplasms associated with histological type and grade.

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

1990 • 1,080 citations

Neu-Protein Overexpression in Breast Cancer

1988 • 860 citations

P53 expression in breast cancer

1988 • 612 citations

Intraductal carcinoma of the breast: Follow-up after biopsy only

1982 • 604 citations

Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer.

1989 • 592 citations

Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading.

1988 • 570 citations

Mammographically detected duct carcinoma in situ. Frequency of local recurrence following tylectomy and prognostic effect of nuclear grade on local recurrence

1989 • 563 citations

Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancer.

1990 • 511 citations

Reduction to Homozygosity of Genes on Chromosome 11 in Human Breast Neoplasia

1987 • 329 citations

Correlation between long-term survival in breast cancer patients and amplification of two putative oncogene-coamplification units: hst-1/int-2 and c-erbB-2/ear-1.

1989 • 321 citations

Intraductal carcinoma. Long-term follow-up after treatment by biopsy alone

1978 • 308 citations

Heterogeneity of intraductai carcinoma of the breast

1989 • 250 citations

Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein.

1987 • 247 citations

Maintenance of p53 alterations throughout breast cancer progression.

1991 • 244 citations

p53 mutations in breast cancer.

1992 • 243 citations

The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast.

1992 • 196 citations

Intracystic papillary carcinoma of the breast after mastectomy, radiotherapy or excisional biopsy alone

2006 • 179 citations

Characterization and Chromosome Assignment of the Human Homolog of int-2, a Potential Proto-Oncogene

1986 • 178 citations

Ductal carcinoma in situ of the breast. Heterogeneity of individual lesions

1994 • 178 citations

Nuclear p53 Immunoreaction Associated with Poor Prognosis of Breast Cancer

1991 • 174 citations

Mutation pattern of the p53 gene as a diagnostic marker for multiple hepatocellular carcinoma.

1992 • 162 citations

correlation between histologic grade of malignancy and copy number of c-erbb-2 gene in breast carcinoma. A retrospective analysis of 176 cases

1990 • 152 citations

The amplification unit on chromosome 11q13 in aggressive primary human breast tumors entails the bcl-1, int-2 and hst loci.

1989 • 114 citations

Allele loss on chromosome 16q24.2-qter occurs frequently in breast cancers irrespectively of differences in phenotype and extent of spread.

1994 • 110 citations

p53 Mutations and c‐erbB‐2 Amplification in Intraductal and Invasive Breast Carcinomas of High Histologic Grade

1993 • 86 citations

Breast conservation therapy for intraductal carcinoma of the breast

1993 • 80 citations

Allelic loss on a chromosome 17 in ductal carcinoma in situ of the breast.

1993 • 73 citations

Different Incidence of Loss of Heterozygosity on Chromosome 16q between Intraductal Papilloma and Intracystic Papillary Carcinoma of the Breast

1994 • 33 citations