Evidence for multiple pathways to cellular senescence.

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

1983 • 446 citations

Combination versus single agent chemotherapy: A review of the basis for selection of drug treatment of cancer

1975 • 398 citations

The two-stage mechanism controlling cellular senescence and immortalization

1992 • 377 citations

Genetic analysis of indefinite division in human cells: identification of four complementation groups.

1988 • 358 citations

Evidence for the Recessive Nature of Cellular Immortality

1983 • 286 citations

Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1

1991 • 257 citations

The Cell Biology of Human Aging

1976 • 235 citations

Induction of Cellular Senescence in Immortalized Cells by Human Chromosome 1

1990 • 195 citations

Genetic analysis of indefinite division in human cells: evidence for a cell senescence-related gene(s) on human chromosome 4.

1991 • 179 citations

Tumor Cell Growth Arrest Caused by Subchromosomal Transferable DNA Fragments from Chromosome 11

1993 • 177 citations

Limited lifespan in somatic cell hybrids and cybrids

1980 • 128 citations

Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1.

1993 • 109 citations

Senescence of immortal human fibroblasts by the introduction of normal human chromosome 6.

1994 • 97 citations

A gene involved in control of human cellular senescence on human chromosome 1q.

1994 • 94 citations

Multiple chromosomes carrying tumor suppressor activity for a uterine endometrial carcinoma cell line identified by microcell-mediated chromosome transfer.

1990 • 79 citations

A preneoplastic stage in the spontaneous neoplastic transformation of syrian hamster embryo cells in culture.

1980 • 70 citations

Altered chromosome 6 in immortal human fibroblasts.

1992 • 63 citations

Immortalization of a human colorectal adenoma cell line by continuous in vitro passage: Possible involvement of chromosome 1 in tumour progression

1988 • 51 citations

Possible involvement of chromosome 1 in in vitro immortalization: Evidence from progression of a human adenoma-derived cell line in vitro

1989 • 41 citations

Immortalization of Syrian hamster embryo cells is in itself a multistep event.

1991 • 24 citations

Karyotype evolution in a simian virus 40-transformed tumorigenic human cell line

1990 • 14 citations

Changes in stem cell populations of rat tracheal epithelial cell cultures at an early stage in neoplastic progression.

1985 • 12 citations