Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

1986 • 2,341 citations

Association of Multiple Copies of the N-mycOncogene with Rapid Progression of Neuroblastomas

1985 • 1,989 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

The c-erb-A gene encodes a thyroid hormone receptor

1986 • 1,505 citations

The c-erb-A protein is a high-affinity receptor for thyroid hormone

1986 • 1,340 citations

Sequence and Expression of Human Estrogen Receptor Complementary DNA

1986 • 1,321 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

Amplification of a Novel v- erb B-Related Gene in a Human Mammary Carcinoma

1985 • 1,064 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

1985 • 607 citations

The neu Gene: an erb B-Homologous Gene Distinct from and Unlinked to the Gene Encoding the EGF Receptor

1985 • 513 citations

Localization of gene for human p53 tumour antigen to band 17p13

1986 • 498 citations

Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas.

1986 • 413 citations

AMPLIFICATION OF c-erbB-2 ONCOGENE IN HUMAN ADENOCARCINOMAS IN VIVO

1986 • 400 citations

Alterations of myc , myb , and ras ^Ha Proto-Oncogenes In Cancers Are Frequent and Show Clinical Correlation

1986 • 379 citations

High incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines.

1986 • 370 citations

Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product

1985 • 368 citations

MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF

1985 • 332 citations

Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line.

1986 • 329 citations

Isolation and characterization of chicken DNA homologous to the two putative oncogenes of avian erythroblastosis virus

1982 • 318 citations

Transforming capacities of avian erythroblastosis virus mutants deleted in the erbA or erbB oncogenes

1983 • 296 citations

Human small-cell lung cancers show amplification and expression of the N-myc gene.

1986 • 293 citations

Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line.

1986 • 253 citations

Gene Amplification of c- myc and N- myc in Small Cell Carcinoma of the Lung

1986 • 253 citations

Human p53 gene localized to short arm of chromosome 17

1986 • 222 citations

New human transforming genes detected by a tumorigenicity assay.

1984 • 217 citations

A v-erbB-related protooncogene, c-erb-B-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma

1985 • 195 citations

Chromosomal localisation of the human homologues to the oncogenes erbA and B.

1984 • 167 citations

Molecular cloning of the neu gene: absence of gross structural alteration in oncogenic alleles.

1986 • 158 citations

Amplification of the c-myc oncogene in one of five human breast carcinoma cell lines.

1984 • 152 citations

Site-specific mutagenesis of avian erythroblastosis virus: erb-B is required for oncogenicity

1983 • 127 citations

A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia.

1984 • 122 citations

Differential amplification and disproportionate expression of five genes in three multidrug-resistant Chinese hamster lung cell lines.

1986 • 113 citations

Human tumor cell lines with EGF receptor gene amplification in the absence of aberrant sized mRNAs

1985 • 99 citations

Isolation and characterization of multiple human genes homologous to the oncogenes of avian erythroblastosis virus.

1983 • 92 citations

New Human Transforming Genes Detected by a Tumorigenicity Assay

1984 • 81 citations

Isolation of a full-length mouse cDNA clone coding for an immunologically distinct p53 molecule.

1985 • 78 citations

The human thyroglobulin gene: A polymorphic marker localized distal to C-MYC on chromosome 8 band q24

1985 • 76 citations

Site-specific mutagenesis of avian erythroblastosis virus: v-erb-A is not required for transformation of fibroblasts

1983 • 56 citations

Co-Amplification of rRNA Genes with CAD Genes in N-(Phosphonacetyl)-L-Aspartate-Resistant Syrian Hamster Cells

1983 • 54 citations

Isolation of a Full-Length Mouse cDNA Clone Coding for an Immunologically Distinct p53 Molecule

1985 • 38 citations

Co-amplification of rRNA genes with CAD genes in N-(phosphonacetyl)-L-aspartate-resistant Syrian hamster cells.

1983 • 26 citations

Human small-cell lung cancers show amplification and expression of the N-myc gene

1987 • 21 citations

An EcoRI restriction fragment length polymorphism (RFLP) in the human c-erb A locus

1985 • 14 citations

Gene Amplification in Small Cell Carcinoma of the Lung

2020 • 1 citations